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ZMAX
Bacterial infections
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Drug Name:

ZMAX Rx

Generic Name and Formulations:
Azithromycin (as dihydrate) 2g; for ext-rel oral susp after reconstitution; cherry-banana flavor; contains 148mg Na+/bottle.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for ZMAX:

Mild-to-moderate susceptible acute bacterial sinusitis in adults. Community-acquired pneumonia in adults and children ≥6mos old.

Adults and Children:

Take on an empty stomach. Sinusitis: 2g once. CAP: <6mos: not established. ≥6mos: <34kg: 60mg/kg (27mg/lb) once; ≥34kg: 2g once. If vomiting occurs within 1 hour post-dose or delayed gastric emptying, consider alternative therapy.

Contraindications:

Macrolide or ketolide related allergy. History of cholestatic jaundice/hepatic dysfunction with prior use.

Warnings/Precautions:

Renal impairment (esp. GFR <10mL/min). Discontinue if signs/symptoms of hepatitis occur. Myasthenia gravis. History of QT prolongation or proarrhythmic conditions. Allergic symptoms may recur after initial successful symptomatic treatment. Neonates: possible infantile hypertrophic pyloric stenosis. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Possible QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval; avoid. Potentiated by nelfinavir. Monitor digoxin, cyclosporine, ergots, hexobarbital, phenytoin, warfarin.

Pharmacological Class:

Macrolide (azalide).

Adverse Reactions:

Diarrhea, nausea, vomiting, abdominal pain, headache; rare: allergy (eg, angioedema, AGEP, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), lab abnormalities; hepatotoxicity, torsades de pointes (esp. elderly), C. difficile-associated diarrhea (evaluate if occurs).

How Supplied:

Pwd (2g/bottle)—1

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