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ZERIT
Viral infections
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Drug Name:

ZERIT Rx

Generic Name and Formulations:
Stavudine 15mg, 20mg, 30mg, 40mg; caps.

Company:
Bristol-Myers Squibb

Therapeutic Use:

Indications for ZERIT:

HIV-1 infection.

Adult:

≥60kg: 40mg every 12hrs; <60kg: 30mg every 12hrs. Withdraw drug if peripheral neuropathy occurs; after complete resolution, may restart at 20mg every 12hrs for patients ≥60kg, or 15mg every 12hrs for patients <60kg; if neuropathy recurs consider discontinuing permanently. Renal impairment: ≥60kg (CrCl 26–50mL/min): 20mg every 12hrs; (CrCl 10–25mL/min): 20mg every 2hrs. <60kg (CrCl 26–50mL/min): 15mg every 12 hrs; (CrCl 10–25mL/min): 15mg every 24hrs. Hemodialysis: ≥60kg: 20mg every 24hrs; <60kg: 15mg every 24hrs. Coincide dose for end of dialysis and give at same time of day on non-dialysis days.

Children:

≤13 days: 0.5mg/kg every 12hrs. ≥14 days: (<30kg): 1mg/kg every 12hrs. ≥30kg: as adult. Withdraw drug if peripheral neuropathy occurs; after complete resolution, may restart at ½ recommended dose; if neuropathy recurs consider discontinuing permanently. Renal impairment: reduce dose or increase dosing interval.

Warnings/Precautions:

Suspend therapy if symptoms of lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occur. Suspend if pancreatitis suspected; may restart if ruled out, monitor closely (do not give with didanosine or hydroxyurea after restarted). Pre-existing liver dysfunction, hepatitis, or other risk factors of liver disease; monitor. Monitor for peripheral neuropathy. Advanced HIV disease, history of peripheral neuropathy, or concomitant neurotoxic drugs: consider reducing dose or discontinuing if neuropathy occurs; may attempt rechallenge at ½ dose. Women, obesity, or prolonged nucleoside exposure: increased risk of toxicity. Renal dysfunction. Diabetes (oral soln). Elderly. Pregnancy (Cat.C): monitor for lactic acidosis if used with didanosine. Nursing mothers: not recommended.

Interactions:

Avoid concomitant zidovudine. Increased risk of toxicity with neurotoxic, hepatotoxic, or pancreatotoxic drugs (eg, didanosine and/or hydroxyurea); avoid. Caution with doxorubicin, ribavirin. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.

See Also:

ZERIT for ORAL SOLUTION

Pharmacological Class:

Nucleoside analogue (reverse transcriptase inhibitor).

Adverse Reactions:

Headache, GI upset, peripheral neuropathy, rash, elevated liver enzymes, elevated amylase, pancreatitis, lactic acidosis or severe hepatomegaly with steatosis, fat redistribution, immune reconstitution syndrome, anorexia, myalgia.

Note:

Register pregnant patients exposed to stavudine by calling (800) 258-4263.

How Supplied:

Caps—60; Soln—200mL

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