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ZAROXOLYN
Edema
Hypertension
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Drug Name:

ZAROXOLYN Rx

Generic Name and Formulations:
Metolazone 2.5mg, 5mg, 10mg; tabs.

Company:
UCB Inc.

Therapeutic Use:

Indications for ZAROXOLYN:

Edema.

Adult:

Individualize. 5–20mg once daily.

Children:

Not established.

Contraindications:

Anuria. Hepatic coma or precoma.

Warnings/Precautions:

Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.

Pharmacological Class:

Diuretic (quinazoline).

Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).

How Supplied:

Tabs—100, 1000

Indications for ZAROXOLYN:

Hypertension.

Adult:

Individualize. 2.5–5mg once daily.

Children:

Not established.

Contraindications:

Anuria. Hepatic coma or precoma.

Warnings/Precautions:

Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.

Pharmacological Class:

Diuretic (quinazoline).

Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).

How Supplied:

Tabs—100, 1000

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