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ZARONTIN
Seizure disorders
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Drug Name:

ZARONTIN Rx

Generic Name and Formulations:
Ethosuximide 250mg; caps.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for ZARONTIN:

Absence seizures.

Adult:

Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses.

Children:

<3yrs: not established. 3–6yrs: initially 250mg daily. >6yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses.

Warnings/Precautions:

Impaired hepatic or renal function. May precipitate tonic-clonic seizures. Discontinue at 1st sign of rash; consider alternative therapy if signs/symptoms of Stevens-Johnson syndrome occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Monitor for depression, suicidal ideation, unusual changes in mood/behavior. Monitor CBCs, kidney and liver function periodically. Change dose gradually. Pregnancy. Nursing mothers: not recommended.

Interactions:

Monitor phenytoin, phenobarbital, valproic acid, other AEDs.

See Also:

ZARONTIN SYRUP

Pharmacological Class:

Succinimide.

Adverse Reactions:

Blood dyscrasias, drowsiness, ataxia, dizziness, headache, GI upset, CNS and psychiatric effects, rash (may be fatal), SLE, DRESS, gingival hyperplasia.

Metabolism:

Hepatic.

Elimination:

Renal.

Generic Availability:

Caps, syrup (YES)

How Supplied:

Caps—100; Syrup—pt

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