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ZANAFLEX CAPSULES
Muscle spasms
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Drug Name:

ZANAFLEX CAPSULES Rx

Generic Name and Formulations:
Tizanidine HCl 2mg, 4mg, 6mg; caps.

Company:
Acorda Therapeutics

Therapeutic Use:

Indications for ZANAFLEX CAPSULES:

Muscle spasticity (due to its short duration of action reserve for when relief is most important).

Adult:

Initially: usually 4mg, may increase by 2–4mg as needed every 6–8 hrs to a max of 3 doses in 24hrs; max 12mg/dose and 36mg/day. Renal impairment (CrCl <25mL/min): reduce dose. May sprinkle contents of capsules on applesauce (may affect absorption). Tabs and caps not bioequivalent under fed conditions. See literature.

Children:

Not recommended.

Contraindications:

Concomitant fluvoxamine, ciprofloxacin.

Warnings/Precautions:

Hepatic dysfunction. Monitor ophthalmic and liver function (aminotransferases at baseline, 1, 3, 6 months, then periodically) and for orthostatic hypotension. Renal dysfunction. Cardiovascular disease. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Avoid other α2-agonists (eg, clonidine). Hypotension possible with other antihypertensives. Avoid concomitant use with other CYP1A2 inhibitors (eg, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, other fluoroquinolones, oral contraceptives, acyclovir, ticlopidine, zileuton); if clinically necessary, use caution. May potentiate CNS depression with alcohol, baclofen, benzodiazepines, other CNS depressants.

See Also:

ZANAFLEX TABLETS

Pharmacological Class:

Alpha-2 agonist.

Adverse Reactions:

Dry mouth, somnolence, asthenia, dizziness, UTI, constipation, liver injury or elevated liver enzymes, vomiting, speech disorder, blurred vision, dyskinesia, nervousness, pharyngitis, hypotension, bradycardia, hallucinations/psychosis.

How Supplied:

Tabs, caps—150

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