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Technique Maps Biomarkers That Predict Immunotherapy Response

Technique Maps Biomarkers That Predict Immunotherapy Response

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With only 1 slide of a tumor section, an analysis of multiple tumor markers can be performed. The technique may help predict response to immunotherapy, which typically evokes responses in only a small group of patients.

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

Novel Pathway Improves Access to Genetic Testing for Women With Ovarian Cancer

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Rapid, robust, and affordable genetic testing for patients with ovarian cancer that allows a much larger portion of patients to benefit from personalized cancer management and their relatives to benefit from preventive strategies can be achieved.

Ipilumumab Feasible for Recurrent Hematologic Cancers After Allogeneic Stem Cell Transplant

Ipilumumab Feasible for Recurrent Hematologic Cancers After Allogeneic Stem Cell Transplant

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Repeat doses of ipilimumab can restore a complete remission in patients with advanced blood cancers who relapse after allogeneic hematopoietic stem cell transplant (alloHSCT).

Increasing Weight Associated With Disease Progression in Multiple Myeloma

Increasing Weight Associated With Disease Progression in Multiple Myeloma

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Increasing body mass index (BMI) allows growth and progression of disease in patients with multiple myeloma, a recently published study has shown.

Chemoradiation Combination Could Preserve Larynx in Patients With Laryngeal and Hypolaryngeal Cancer

Chemoradiation Combination Could Preserve Larynx in Patients With Laryngeal and Hypolaryngeal Cancer

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Researchers assessed the rates of laryngeal preservation and laryngectomy-free survival in patients with laryngeal or hypopharyngeal cancer who received the monoclonal antibody cetuximab and radiation therapy or radiation therapy alone.

Anti-HER2 Therapies Link With Heart Blood Vessel Development Explains Cardiovascular Side Effects of Trastuzumab

Anti-HER2 Therapies Link With Heart Blood Vessel Development Explains Cardiovascular Side Effects of Trastuzumab

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Therapies targeting ErbB2 (HER2), such as trastuzumab (Herceptin), are often associated with cardiovascular side effects. ErbB2 was recently found to also be expressed by vascular endothelial cells, and is an example of how tissue growth and blood vessel patterning are integrated at the molecular level.

Cancer Cell Lines Can Predict Treatment Response, Improve Personalized Therapy

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Patient-derived cancer cell lines contain most of the genetic changes found in patients' tumors and could be used to determine tumor response to treatment, increasing the success rate of new personalized therapies for cancer.

Acupressure Improves Fatigue, Sleep, and Quality of Life for Survivors of Breast Cancer

Acupressure Improves Fatigue, Sleep, and Quality of Life for Survivors of Breast Cancer

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Acupressure reduced persistent fatigue in women who had been treated for breast cancer, improving both sleep and quality of life.

Adjuvant Therapy Improves Survival in Stage II Colon Cancer, Study Confirms

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A very large retrospective study of patients with stage II colon cancer found adjuvant therapy improves survival, regardless of treatment regimen, patient age, or high-risk pathologic risk features.

Hybrid Immune Cells Have Antitumor Effects in Early Stage Lung Cancer

Hybrid Immune Cells Have Antitumor Effects in Early Stage Lung Cancer

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A subset of tumor-associated neutrophils (TANs) has hybrid characteristics of both neutrophils and antigen-presenting cells in samples from early stage human lung cancers.

Clinician Communication, Adherence to Protocols, and Presence of Pharmacists Improve Outcomes in ICUs

Clinician Communication, Adherence to Protocols, and Presence of Pharmacists Improve Outcomes in ICUs

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Oncologic patients are among the main users of ICUs and are vulnerable to infections and adverse drug reactions. However, relatively simple processes of organization can reduce the risk of these problems.

Identifying Smaller ctDNA Fragments Improves Sensitivity of Liquid Biopsy

Identifying Smaller ctDNA Fragments Improves Sensitivity of Liquid Biopsy

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Circulating tumor DNA (ctDNA) has shorter fragment sizes than DNA fragments from healthy cells that have died, and this may increase the clinical utility of liquid biopsies.

Dual Antigen Targeting by CAR T Cells Improves Immunotherapeutic Technique

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Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.

Decision Support and Shared Decision Making Help Patients Choose Plan for Low-Risk Prostate Cancer

Decision Support and Shared Decision Making Help Patients Choose Plan for Low-Risk Prostate Cancer

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Using an online decision-support tool led to most men with low-risk prostate cancer choosing active surveillance with less conflict about their decision.

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

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Although most adolescent survivors of childhood cancer have no reported psychological symptoms, those who do often have multiple symptoms and distinct symptom profiles.

Advanced Endoscopy Techniques May Be Safe Alternative to Surgery for Most Difficult-to-Remove or Large Polyps

Advanced Endoscopy Techniques May Be Safe Alternative to Surgery for Most Difficult-to-Remove or Large Polyps

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Most patients with large or difficult-to-remove colorectal polyps have a lower incidence of cancer than previously thought; therefore, more advanced endoscopic techniques that spare the colon may be a better and safer alternative to a traditional operation in some cases.

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence

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Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

Hypermutated Hotspots Are Biomarkers Predictive of Better Outcomes in Breast Cancer

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Patients with kataegis, a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome, have less invasive tumors and better prognoses.

Cancer Risk Higher in Patients With Heart Failure After a First Heart Attack

Cancer Risk Higher in Patients With Heart Failure After a First Heart Attack

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The risk of developing cancer increases in people who experience heart failure after their first heart attack compared with people who experience no heart failure after their first heart attack.

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer

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The multikinase inhibitor regorafenib significantly improved overall survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase 3 RESORCE trial.

Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries

Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries

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Training primary care providers (PCP) to detect early melanoma led to increased melanoma diagnoses, but had little impact on skin surgeries or dermatology visits.

Mimicking Fasting During Chemotherapy Enhances T Cell Activity in Preclinical Study

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Fasting during chemotherapy treatment may increase the presence of cancer-killing T cells, according to recent study data.

Understanding a Molecular Switch Modulating Tumor Metastasis and Chemotherapy Resistance

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Dab2 is an endocytic adaptor and tumor suppressor whose expression occurs during the epithelial-mesenchymal transition, which is mediated by TGF-beta. This study sought to understand how Dab2 regulates apoptosis.

Chronic Pain Is More Likely for Women Who Undergo Armpit Lymph Node Surgery for Breast Cancer

Chronic Pain Is More Likely for Women Who Undergo Armpit Lymph Node Surgery for Breast Cancer

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Risk factors for chronic pain after breast cancer surgery include axillary lymph node dissection, younger age, and radiation therapy. Only axillary lymph node dissection is a high-yield target for a modifiable risk factor to prevent the persistent pain after breast cancer surgery.

Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma

Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma

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Researchers discovered that changes in the bone marrow needed for multiple myeloma to grow have already taken hold in patients with MGUS.

Significant Increase in US Cancer Center Advertising Seen in Past Decade

Significant Increase in US Cancer Center Advertising Seen in Past Decade

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US cancer centers have dramatically increased their spending on advertising to promote their services, and the bulk of this spending was by for-profit organizations.

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

Telomere Length Predicts Risk for Delayed Recovery in Pediatric Patients With AML

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Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.

Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers

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Women who carry the BRCA1 mutation are at increased risk for serous/serous-like endometrial carcinoma after risk-reducing salpingo-oophorectomy. Yet uncertainty exists over the need to perform a full hysterectomy in these women.

Ratio of Biomarkers on Imaging Identifies Aggressiveness of DCIS

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A new technique combines imaging and mathematics to identify aggressive forms of ductal carcinoma in situ (DCIS), or stage 0 breast cancer, from nonaggressive varieties.

Annual Follow-up With Low-Dose CT Is Sufficient for Some Lung Nodules

Annual Follow-up With Low-Dose CT Is Sufficient for Some Lung Nodules

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For nonsolid nodules identified by CT screening for lung cancer, annual screening with low-dose CT can eliminate the need for biopsy or surgery.

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