Silenced gene associated with uncontrolled growth in multiple myeloma

Multiple myeloma may be linked to a silenced gene, according to a study published in PLoS ONE (2010 Jul 9;5(7):e11483).

During the study, designed to present a new model for the development and progression of multiple myeloma, researchers used large cohorts of myeloma patients to identify a profile of genes that are silenced by epigenetic mechanisms in the malignant plasma cell.

When researchers compared the silenced gene profile to normal plasma cells they found that the silenced genes had a common factor in being targets and controlled by the Polycomb repressor complex (PcG). In addition, researchers reported that inhibitors of PcG also could decrease the growth of tumor cells in an animal model of myeloma.

“A new strategy for treating multiple myeloma could be to develop drugs that are targeted to the PcG complex, leading to reactivation of the silenced gene profile,” said Helena Jernberg Wiklund, professor at the Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University and one of the investigators in the study.

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs