Web Exclusives

New gene implicated in progression and recurrence of triple-negative breast cancer

A gene not previously associated with breast cancer appears to play a pivotal role in the growth and progression of triple-negative breast cancer.

Germline EGFR T790M mutation indicates a high risk for familial NSCLC regardless of smoking

Two studies provide new insight into a germline epidermal growth factor receptor T790M mutation in familial non-small cell lung cancer, and suggest the need for tailored approaches for early detection and treatment.

Hope for preserving fertility in young boys with cancer

Scientists have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer.

Certain genetic variants increase recurrence risk for bladder cancer

Inheriting certain DNA sequences can affect the prognosis of bladder cancer patients, according to a new study.

Adult cancer drug offers hope against aggressive pediatric brain tumor

The quest to improve survival of children with a high-risk brain tumor has led investigators to two drugs already used to treat adults with breast, pancreatic, lung, and other cancers.

Some breast cancer tumors hijack epigenetic machinery to evade drugs

A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, according to researchers.

PET imaging before surgery reduces unnecessary lung surgery by half

New quantitative data suggests that 30% of the surgeries performed for non-small cell lung cancer patients in a community-wide clinical study were deemed unnecessary.

3D MRI predicts survival after chemotherapy for liver tumors

In a series of studies involving Americans with liver tumors, researchers used specialized three-dimensional MRI scans to precisely measure whether highly toxic chemotherapy is working.

New drug successful against crizotinib-resistant, ALK-positive lung cancer

A new drug, ceritinib, appears to be effective against advanced ALK-positive non-small cell lung cancer, both in tumors that have become resistant to crizotinib and in those never treated with the older drug.

Less invasive technique possible for vulvar cancer

Sentinel lymph node dissection in women with vulvar malignancies allowed gynecologic oncology surgeons to identify and remove just the sentinel nodes and follow the patients for complications and recurrence.

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