In research that could ultimately lead to many new medicines, scientists have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
A new analysis confirmed the importance of known prognostic factors such as performance status and tumor grading for having a long-term outcome in patients treated with pazopanib for metastatic soft tissue sarcoma. In addition, hemoglobin at baseline was found to be a new prognostic factor.
Pancreatic stellate cells, which normally aid tissue repair, unwittingly help pancreatic cancer grow and spread in a method of cell hijack only seen before in brain and breast cancer, according to new research. The research also revealed that the process can be blocked, thereby preventing the growth and spread of the tumor.
Experts have identified three major sources of high cancer costs and argue that cancer doctors can likely reduce them without harm to patients. The cost-cutting proposals call for changes in routine clinical practice involved in end-of-life care, medical imaging, and drug pricing.
A recent study has found that, within the Asian population, the frequency of epidermal growth factor receptor mutations associated with other demographic and clinical characteristics is higher than previously reported, even in patients with a history of smoking.
The chemical composition of commonly used chemotherapy drugs can be altered so that they only become active when they come into contact with palladium, and cancer patients could one day experience fewer side effects from chemotherapy since this discovery opens the door for more targeted treatments.
A group of researchers discovered a promising new approach to treating leukemia by disarming a gene that is responsible for tumor progression.
Grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing chemotherapy side effects, according to new research.
A panel of 55 genes, almost all of which are impacted by the loss of a particular protein, appears to predict if breast cancer will become invasive, leading to poorer survival, according to new research.
The protein SPOP, which is most frequently mutated in human prostate cancers, is a key regulator of androgen receptor activity that prevents uncontrolled growth of cells in the prostate and thus helps prevent cancer.
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