Radiation-induced toxicity risk in prostate cancer predicted by variations in key gene

Key genetic variants may affect how cancer patients respond to radiation treatments, according to a new study. The research team found that variations in the TANC1 gene are associated with a greater risk for radiation-driven side effects in prostate cancer patients, which include incontinence, impotence, and diarrhea.

The current results, published in Nature Genetics (2014; doi:10.1038/ng.3020), are based on a genome-wide association study, a type of study in which researchers examine numerous genetic variants to see if any of them are associated with a certain type of complication, which could sometimes emerge years after treatment was completed.

"Our findings, which were replicated in two additional patient groups, represent a significant step towards developing personalized treatment plans for prostate cancer patients," said Barry S. Rosenstein, PhD, Professor, Radiation Oncology, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai in New York, New York, and the lead Mount Sinai investigator on the study. "Within 5 years, through the use of a predictive genomic test that will be created using the data obtained in the recent study, it may be possible to optimize treatment for a large number of cancer patients."

For the study, Rosenstein and his team obtained blood samples from nearly 400 patients who were receiving radiotherapy treatment for prostate cancer. The blood samples were screened for roughly one million genetic markers, and each patient was monitored for at least 2 years to track incidents of side effects from the radiation. Data analysis showed which genetic markers were consistently associated with the development of complications following radiotherapy.

"The next step is to validate the results, and see if the same markers predict similar outcomes in patients with other forms of cancer," said Rosenstein. Using the genomic test being developed, treatment plans can be adjusted to minimize adverse effects. This would allow for an improved quality life for many cancer survivors.

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