Piggy-backing proteins ride white blood cells to destroy metastasizing cancer

A new technique targets metastasizing cancer cells that are traveling through the bloodstream by hitching cancer-killing proteins on white blood cells.

“These circulating cancer cells are doomed,” said senior author Michael King, PhD, of Cornell University in Ithaca, New York. “About 90% of cancer deaths are related to metastases, but now we've found a way to dispatch an army of killer white blood cells that cause apoptosis—the cancer cell's own death—obliterating them from the bloodstream. When surrounded by these [white blood cells], it becomes nearly impossible for the cancer cell to escape.”

Surgery and radiation are effective at treating primary tumors, but difficulty in detecting metastatic cancer cells has made treatment of the spreading cancers problematic, said the scientists.

King and his colleagues injected human blood samples, and later mice, with two proteins: E-selectin (an adhesive) and TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand). The TRAIL protein joined with the E-selectin protein was able to stick to leukocytes—white blood cells—abundant in the bloodstream. When a cancer cell comes into contact with TRAIL, which is nearly unavoidable in the frenzied flow of blood, the cancer cell essentially kills itself.

“The mechanism is surprising and unexpected in that this repurposing of white blood cells in flowing blood is more effective than directly targeting the cancer cells with liposomes or soluble protein,” say the authors.

In the laboratory, King and his colleagues tested this concept's efficacy.

When treating cancer cells with the proteins in saline, they found a 60% success rate in killing the cancer cells. In normal laboratory conditions, the saline lacks white blood cells to serve as a carrier for the adhesive and killer proteins. Once the proteins were added to flowing blood that mimicked human body conditions, however, the success rate in killing the cancer cells jumped to nearly 100%. Their study was published in Proceedings of the National Academy of Sciences (2014; doi:10.1073/pnas.1316312111).

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