Older patients have more complications after colorectal cancer resection

Even though incidence of and mortality from colorectal cancer are improving, older patients have worse risk-adjusted outcomes than younger patients, according to a new study.

Gastrointestinal cancers are common in the elderly and have their peak occurrences in the sixth and seventh decades of life. Colorectal cancer (CRC) is a leading cause of death, and surgery remains the curative treatment.

The authors, Mehraneh D. Jafari, MD, and colleagues from the University of California, Irvine School of Medicine, examined the trends and outcomes of colorectal cancer surgery in the elderly in a nationwide sample of inpatients from 2001 through 2010. Patients were divided into age groups: 45 to 64 years, 65 to 69 years, 70 to 74 years, 75 to 79 years, 80 to 84 years, and 85 years and older.

Among the more than 1 million patients with colorectal cancer included in the study, 63.8% of the operations were performed on patients 65 years and older and 22.6% on patients 80 years and older. Patients 80 years and older were 1.7 times more likely to require urgent admission to the hospital than patients younger than 65 years.

Compared to patients 45 to 64 years, higher hospital death and complication rates were seen in older patients. Patients 80 years and older also had a $9,492 higher hospital charge and a longer length of stay at the hospital (2.5 days longer) compared with patients younger than 65 years. The total number of colon cancer surgeries decreased an average of 5.1% and 7% per year for the entire population and the aging population, respectively. Mortality rates improved in all age groups during the decade studied.

“In this extensive review of national trends of CRS [colorectal cancer resection], we observed that, despite the improvements in mortality and a decrease in the incidence of CRS, older patients continue to have worse risk-adjusted outcomes compared with those who are younger,” stated the authors. The study was published in JAMA Surgery (2014; doi:10.1001/jamasurg.2013.4930).

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