Leading cancer experts write a prescription for more affordable cancer drugs

Leading cancer experts write a prescription for more affordable cancer drugs
Leading cancer experts write a prescription for more affordable cancer drugs

A group of 118 of the nation's leading cancer experts have drafted a prescription for reducing the high cost of cancer drugs and voiced support for a patient-based grassroots movement demanding action on the issue. Their recommendations and support are outlined in a commentary, co-authored by the group, in the journal Mayo Clinic Proceedings (2015; doi:10.1016/j.mayocp.2015.06.001).

"High cancer drug prices are affecting the care of patients with cancer and our health care system," said lead author Ayalew Tefferi, MD, a hematologist at Mayo Clinic. "The average gross household income in the [United States] is about $52,000 per year. For an insured patient with cancer who needs a drug that costs $120,000 per year, the out-of-pocket expenses could be as much as $25,000 to $30,000—more than half their average household income."

The group cites a 2015 study by D.H. Howard and colleagues, published in the Journal of Economic Perspectives (2015;29[1]:139-162), that found cancer drug prices have risen by an average of $8,500 per year over the past 15 years.

"When you consider that cancer will affect 1 in 3 individuals over their lifetime, and [with] recent trends in insurance coverage [that] put a heavy financial burden on patients with out-of-pocket expenses, you quickly see that the situation is not sustainable," Tefferi, said. "It's time for patients and their physicians to call for change."

The group suggested a number of actions that would improve the situation and allow market forces to work better.

  • Create a post-US Food and Drug Administration drug approval review mechanism to propose a fair price for new treatments based on the treatment's value to patients and heath care
  • Allow Medicare to negotiate drug prices
  • Allow the Patient Centered Outcomes Research Institute, created through the Affordable Care Act, to evaluate the benefits of new treatments and similar organizations to include drug prices in their assessments of the treatment value
  • Allow importation of cancer drugs across borders for personal use (eg, drug prices in Canada are approximately half the prices in the United States)
  • Pass legislation to prevent drug companies from delaying access to generic drugs (pay for delay)
  • Reform the patent system to make it more difficult to prolong product exclusivity unnecessarily (patent evergreening)
  • Encourage organizations that represent cancer specialists and patients (eg, American Society of Clinical Oncology [ASCO], American Society of Hematology [ASH], American Association for Cancer Research [AACR], American Cancer Society [ACS], and the National Comprehensive Cancer Network [NCCN]) to consider the overall value of drugs and treatments in formulating treatment guidelines

The group also supports the patient-based, grass-roots movement on change.org that advocates against high cancer drug prices with the goal of drawing the attention of pharmaceutical companies and elected representatives to this issue.

The authors wrote, "with proper support of these grass-roots efforts and proper use of that support downstream, it should be possible to focus the attention of pharmaceutical companies on this problem and to encourage our elected representatives to more effectively advocate for the interests of their most important constituents among the stakeholders in cancer—American cancer patients."

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