Kidney removal fails to improve survival of older patients with kidney cancer

Older patients with localized kidney cancer do not benefit from kidney removal, according to a study published in Cancer (2010 May 10 [Epub ahead of print]).

Steve Campbell, MD, PhD, of the Cleveland Clinic, and colleagues conducted a study to examine whether surgical kidney removal improved survival better than active monitoring. Investigators studied data on 537 patients with localized kidney tumors that were ≤ 7cm in diameter and were detected in patients 75 years or older. Of the study cohort, 20% were closely monitored, 53% had kidney-sparing surgery, and 27% underwent surgical kidney removal.

Investigators reported that after an average follow-up of approximately 4 years, 28% of patients died. Cancer progression was responsible for only 4% of deaths, and older age and additional medical conditions resulted in an increase of risk of patients dying.

The study also revealed that patients who had a cancerous kidney removed experienced dysfunction of their remaining kidney at a faster rate compared to those who did not. Surgical kidney removal was also linked to an increased risk of dying from cardiovascular causes.

“Current research is indicating over-treatment of localized renal tumors, and our data suggest that active surveillance is a reasonable strategy and one that is greatly underutilized in the elderly population,” the authors wrote. “The potential benefits of kidney-sparing surgery in elderly patients who have the lowest risk for heart-related deaths and the greatest life expectancy warrant further investigation.”

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs