Imaging software could improve breast cancer diagnosis process

New software could speed up breast cancer diagnosis with 90% accuracy and without the need for a specialist.
New software could speed up breast cancer diagnosis with 90% accuracy and without the need for a specialist.

New software could speed up breast cancer diagnosis with 90% accuracy without the need for a specialist, according to research published in Breast Cancer Research (2015; doi:10.1186/s13058-015-0617-9).

This could improve breast cancer management, particularly in developing countries where pathologists are not routinely available.

"To evaluate fresh breast tissue at the point of care could change the current practice of pathology," said Rebecca Richards-Kortum, PhD, of Rice University in Houston, Texas. "We have developed a faster means to classify benign and malignant human breast tissues using fresh samples and thereby removing the need for time consuming tissue preparation."

Breast cancer diagnosis is an intricate process. Tissue has to be obtained, and then rigorously prepared and assessed in the context of core needle biopsy or surgical excision. Pathologists must currently undergo a complex method to prepare tissue samples for assessment followed by a lengthy diagnosis process.

The researchers used high-speed optical microscopy of intact breast tissue specimens to analyze breast tissue. This automated method for diagnosing breast cancer from tissue samples is performed without the need for complex tissue sample preparation or assessment by a specialist pathologist.

"We performed our analysis without tissue fixation, cutting, and staining and achieved comparable classification with current methods. This cuts out the tissue preparation process and allows for rapid diagnosis. It is also reliant on measurable criteria, which could reduce subjectivity in the evaluation of breast histology," said Richards-Kortum.

The program analyzes images of freshly cut human breast tissue samples taken using a confocal fluorescence microscope to determine certain parameters typically used in breast tissue analysis. These parameters are then inputted into a classification tree the researchers developed to determine whether the tissue sample is benign or malignant.

Although this could have substantial clinical relevance, some limitations need to be overcome before the software can be regularly used.

Certain criteria are reliant on the user's observations, which could lead to incorrect classification of breast tissue. Optical microscopy is not frequently used in patient care because of its cost and required high maintenance.

"We are excited about the possibility to use these imaging techniques to improve access to histologic diagnosis in developing regions that lack the human resources and equipment necessary to perform standard histologic assessment," said first author Jessica Dobbs, a PhD candidate at Rice University.

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