Pain Tolerance Lower in Abstinent Smokers Before, Following Surgery

Pain Tolerance Lower in Abstinent Smokers Before, Following Surgery

Abstinent smokers may have reduced preoperative pain tolerance and increased postoperative opioid use compared with nonsmokers.

FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC

FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC

Combination therapy with lenvatinib and pembrolizumab is granted Breakthrough Therapy Designation for the treatment of advanced or metastatic renal cell carcinoma (RCC).

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

A longitudinal study assessed psychological status of postoperative patients with breast cancer between adjuvant chemotherapy for anxiety and depression.

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

A reduced risk of squamous cell carcinoma, but not basal cell carcinoma, was observed for one year in at-risk individuals treated with fluorouracil.

Smoking Quit Rates Not Improved With Use of Pharmaceutical Cessation Aids

Smoking Quit Rates Not Improved With Use of Pharmaceutical Cessation Aids

Using data from the TUS-CPS, researchers sought to determine the effect of pharmaceutical smoking cessation aids on long-term quit rates among patients who smoke tobacco.

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

The safety of breast implants has not been confirmed despite widespread use.

Handgrip Strength Test is Feasible to Predict Outcomes Among Patients with Cancer

Handgrip Strength Test is Feasible to Predict Outcomes Among Patients with Cancer

Although dynapenia and weak HGS is associated with poor outcomes in patients with cancer, it is not routinely assessed in this population.

Married Status May Improve Survival Outcomes in Hepatocellular Carcinoma

Married Status May Improve Survival Outcomes in Hepatocellular Carcinoma

Recent studies have suggested that married patients experience a survival benefit for various cancers; marriage has been associated with earlier detection, undergoing treatment, as well as better economic status and social support.

Surgery May Be Superior to Stereotactic Body RT for Early Stage Non-small Cell Lung Cancer

Surgery May Be Superior to Stereotactic Body RT for Early Stage Non-small Cell Lung Cancer

SBRT provides excellent local control and an adequate safety profile, but there is a lack of data comparing SBRT to resection among patients eligible for surgery.

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA grants Breakthrough Therapy designation for ribociclib as an initial endocrine-based therapy for HR+/HER2- breast cancer in premenopausal or perimenopausal women.

2-Year Rituximab Maintenance Therapy Prolongs PFS in Elderly With CLL

2-Year Rituximab Maintenance Therapy Prolongs PFS in Elderly With CLL

Investigators sought to determine the efficacy of 2-year rituximab maintenance therapy in elderly patients with CLL who achieve a complete response to abbreviated FCR induction therapy.

Imatinib an Effective Front-line Therapy for Patients With Pediatric CML

Imatinib an Effective Front-line Therapy for Patients With Pediatric CML

Patients received imatinib 300 mg/m2, 400 mg/m2, and 500 mg/m2 for chronic phase, accelerated phase, and blast phase disease, respectively.

Atopic Dermatitis Linked to Increased Risk of Skin Cancer

Atopic Dermatitis Linked to Increased Risk of Skin Cancer

Individuals with a history of atopic dermatitis have a higher risk of squamous cell carcinoma development, research indicates.

Coffee Consumption Associated With Beneficial Health Outcomes

Coffee Consumption Associated With Beneficial Health Outcomes

Coffee consumption was found to be generally safe and more likely to benefit health than harm.

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

In an effort to find alternatives to cisplatin as a radiation sensitizer, due to its dose-dependent toxicity and resistance, researchers are exploring food-based options such as blueberry extract.

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Exercise Reduces Sleep Problems Experienced by Breast Cancer Survivors

Researchers examined the impact of BEAT Cancer intervention on sleep for breast cancer survivors.

Carfilzomib Associated With Cardiovascular Adverse Events in Multiple Myeloma

Carfilzomib Associated With Cardiovascular Adverse Events in Multiple Myeloma

For this meta-analysis and systematic review, investigators compiled phase 1 to 3 prospective clinical trials of carfilzomib therapy for patients with MM that had evaluable toxic effects data.

Patients Report Significant Fatigue with Sorafenib, Sunitinib in Renal Cell Carcinoma

Patients Report Significant Fatigue with Sorafenib, Sunitinib in Renal Cell Carcinoma

Although TKIs improve outcomes, they are still associated with toxicities common with cancer therapies, such as fatigue.

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

Evidence from previous studies for patients with ovarian and endometrial cancers has suggested that goshajinkigan may treat and prevent CIPN.

Brentuximab Vedotin and Bendamustine Proves Effective as Second-line Hodgkin Lymphoma Treatment

Brentuximab Vedotin and Bendamustine Proves Effective as Second-line Hodgkin Lymphoma Treatment

Patients who received the recommended phase 1 dose of brentuximab vedotin and bendamustine had an overall response of 78%.

Tumor-treating Fields Useful to Improve Glioblastoma Outcomes

Tumor-treating Fields Useful to Improve Glioblastoma Outcomes

Adverse event rates were similar in both trial groups, though patients treated with TTFields were much more likely to have mild to moderate skin toxicity.

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers

The US FDA approved pertuzumab in combination with trastuzumab and chemotherapy for adjuvant treatment of HER2-positive early breast cancer, and converted accelerated to full approval for the regimen as neoadjuvant therapy in certain breast cancers.

Atezolizumab Has Some Benefits in Urothelial Carcinoma, But OS Not Improved

Atezolizumab Has Some Benefits in Urothelial Carcinoma, But OS Not Improved

In the IMvigor 311 trial, researchers sought to determine if atezolizumab improves overall survival for patients with metastatic urothelial carcinoma vs physicians' choice of 3 IV regimens.

Pazopanib Plus Paclitaxel Does Not Improve Outcomes in Recurrent Ovarian Cancer

Pazopanib Plus Paclitaxel Does Not Improve Outcomes in Recurrent Ovarian Cancer

Results of a double-blind phase 2 study determined if adding oral pazopanib to intravenous paclitaxel improved outcomes for women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.

Sarcopenia Severity Prognostic of Postchemotherapy Outcomes in the Elderly

Sarcopenia Severity Prognostic of Postchemotherapy Outcomes in the Elderly

Using a series of functional tests, researchers determined the significance of sarcopenia severity after chemotherapy in older patients with cancer and its effect on their physical independence.

No Increased Risk for Melanoma in Patients With MM

No Increased Risk for Melanoma in Patients With MM

An increased prevalence of melanoma has been observed in patients with various immunocompromised conditions.

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

Mortality Higher in Women With Breast Cancer and Comorbid Mental Illness

In a retrospective study of SEER-Medicare data, researchers determined the survival outcomes of women with breast cancer and comorbid mental illness vs those without mental illness.

Researchers Find No Link Between Acne and Malignant Melanoma in Men

Researchers Find No Link Between Acne and Malignant Melanoma in Men

Individuals categorized as overweight or obese had a significantly increased risk for malignant melanoma.

Hearing Loss, Tinnitus May Predict Worse Outcomes for Cancer Survivors

Hearing Loss, Tinnitus May Predict Worse Outcomes for Cancer Survivors

A survey of 754 cancer survivors sought to determine the association between number of neurotoxicities such as CIN, hearing loss, and tinnitus and outcomes for these patients.

Venetoclax Effective in Ibrutinib-Failed Chronic Lymphocytic Leukemia

Venetoclax Effective in Ibrutinib-Failed Chronic Lymphocytic Leukemia

The efficacy and safety of venetoclax in patients with relapsed/refractory CLL that progressed during or after ibrutinib therapy was determined in an open-label, phase 2 study.

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Artificial Intelligence Promising for Breast Cancer Metastases Detection

Two studies evaluate use of deep learning algorithm; one for breast cancer, the other for diabetic retinopathy

Ovarian Cancer Screening Potentially Cost-Effective in the United States

Ovarian Cancer Screening Potentially Cost-Effective in the United States

Multimodal screening is more expensive, but reduces ovarian cancer mortality, researchers found.

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

For this study, researchers sought to determine the effect exercise would have on severity of symptoms for patients who develop CIPN after taxane, platinum, or vinca alkaloid based chemotherapy.

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

SABCS: Modest Weight Loss Cuts Postmenopause Breast Cancer Risk

Postmenopausal women with weight gain had increased risk of triple-negative breast cancer, research indicates.

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

A survey of pediatric oncology providers including physicians, nurses, and social workers reveals their willingness to consider medical marijuana for children with cancer, as well as their reasons against its use in these patients.

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

Fifty-five percent of patients treated with pembrolizumab survived through 24-months compared with 43% of patients treated with ipilimumab.

High-Dose Dexamethasone Effective With Less Adverse Effects in ITP vs Corticosteroids

High-Dose Dexamethasone Effective With Less Adverse Effects in ITP vs Corticosteroids

In this randomized trial, investigators sought to determine the effectiveness of high-dose dexamethasone vs conventional prednisone therapy in treatment-naïve patients with ITP. Results were presented at ASH 2017.

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

A retrospective study, presented at ASH 2017, determined the effectiveness of aspirin in reducing risk of VTE in patients with multiple myeloma at high risk of developing VTE.

Relapsed Ph-Negative Acute Lymphoblastic Leukemia Incurs a High Economic Burden

Relapsed Ph-Negative Acute Lymphoblastic Leukemia Incurs a High Economic Burden

Recent study findings investigated the economic burden of patients with relapsed Ph-negative ALL, and the adverse events of special interest that are most likely to have the greatest impact. These findings were presented at ASH 2017.

Ruxolitinib Beneficial in Hydroxyurea Resistant/Intolerant Polycythemia Vera

Ruxolitinib Beneficial in Hydroxyurea Resistant/Intolerant Polycythemia Vera

Data presented at ASH 2017 confirm that ruxolitinib improves hematocrit control, hematologic remission, and reduction in spleen size in some patients with polycythemia vera who fail hydroxyurea.

Arterial Thrombotic Events Associated With First-line Nilotinib for CML in Older Adults

Arterial Thrombotic Events Associated With First-line Nilotinib for CML in Older Adults

A retrospective analysis of patients with CML determined prevalence of arterial thrombotic events in those receiving nilotinib as first-line treatment and prevalence by patient age. Data were presented at ASH 2017.

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

Data presented at ASH 2017 illustrates the effectiveness of 2 prophylactic antiemetic regimens in pediatric patients receiving moderately or highly emetogenic chemotherapy.

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Quality of Life During Maintenance Therapy Better With Lower Dose, More Often

Trial investigates which of 3 maintenance regimens of nab-paclitaxel has the most ideal impact on quality of life in patients with metastatic breast cancer. Results were presented at SABCS 2017.

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

Most Influential in Breast Reconstruction Decision: Surgeon, Spouse, GP

A study from French researchers identified which people are the most likely to influence a breast cancer patient's decision whether to undergo breast reconstruction. These findings were presented at SABCS 2017.

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

MOCHA App Helps Breast Cancer Survivors Achieve Weight-Loss Goals

A team from Methodist Hospital Cancer Center discuss an app developed at the facility that helps breast cancer survivors with nutrition and physical activity at SABCS 2017.

ASHP and Partners Urge Congress to Action on Drug Shortages

ASHP and Partners Urge Congress to Action on Drug Shortages

Groups urge Congress to take immediate action, provide transparency, and improve drug manufacturing.

Physical Examination Sufficient Work-up for Complaints of Breast Pain

Physical Examination Sufficient Work-up for Complaints of Breast Pain

A single-center analysis demonstrates likelihood that mastalgia indicates presence of breast cancer and extensiveness of common work-up for the complaint. These findings were presented at SABCS 2017.

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

EMBRACE at Dana-Farber Improves Care in Metastatic Breast Cancer

A team from Dana-Farber Cancer Institute describe EMBRACE, their comprehensive care program for patients with metastatic breast cancer at SABCS 2017.

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Current Findings in Trial Evaluating Paclitaxel Substitution in Invasive Breast Cancer

Researchers presented an update of findings in the GeparSepto trial, which seeks to determine whether improvements in pathologic complete response can be translated to a survival benefit, at SABCS 2017.

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Bio-individualized Diet Helps Breast Cancer Survivors Stabilize Weight, Glucose

Novel weight reduction plan helps breast cancer survivors achieve and maintain a healthy weight and glucose level, according to a presentation at SABCS 2017.

Best Antiemetic Therapies for Alleviating CINV: A Literature Review

Best Antiemetic Therapies for Alleviating CINV: A Literature Review

A review of 12 antiemetic regimens identified 3 that may be more effective than conventional regimens, a study presented at SABCS 2017 has shown.

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

Balancing Early Palliative Care With Active Treatment in Advanced Breast Cancer

An approach for incorporating palliative care into oncologic care early after diagnosis is explained in an education session at the 2017 SABCS.

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

FDA Approves Biosimilar Trastuzumab-dkst for Breast and Stomach Cancers

Ogivri was granted FDA approval to treat HER2 breast and gastric or gastroesophageal junction adenocarcinoma cancers.

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Adjuvant Therapy Duration a Continuous Discussion in HR+ Breast Cancer

Choosing the optimal adjuvant therapy option for a patient with early-stage HR-positive breast cancer should be a continuous discussion with the patient, according to a presentation at SABCS 2017.

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Epigenetic Modulation, Checkpoint Inhibition Showed Potential in HER2 Breast Cancer

Using a mouse model of HER2+ breast cancer, researchers tested the efficiency of combined epigenetic modulation and checkpoint inhibition using the histone deacetylase inhibitor ENT and antibodies for 2 checkpoint inhibitor proteins. These findings were presented at the 2017 SABCS.

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

Adjuvant Endocrine Therapy Benefits Younger Women With ER+ Breast Cancer

A comparison of adjuvant endocrine therapies showed one option provided greater reduction in disease recurrence among premenopausal women with ER+ breast cancer.

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Partial Response Reported With Abemaciclib for Breast Cancer Metastases to Brain

Researchers seeking to determine whether breast cancer metastases to the brain would respond to abemaciclib presented the results of a phase 2 Simon 2-stage trial at SABCS 2017.

Ibrutinib Effective As First-line Therapy in Waldenström's Macroglobulinemia

Ibrutinib Effective As First-line Therapy in Waldenström's Macroglobulinemia

Ibrutinib — a Bruton tyrosine kinase inhibitor — is currently used among patients with WM who have previously received treatment. This prospective, phase 2 study sought to determine its efficacy as a first-line therapy in treatment-naive patients.

More Communication, Support Needed to Manage Symptom Burden in CML

More Communication, Support Needed to Manage Symptom Burden in CML

Despite advancements in treatment of CML, many patients still experience adverse effects of their disease and treatments. Therefore, researchers conducted a survey of patients to determine whether they felt assistance and support met their needs.

Lymph Node Density Helps Predict Thyroid Cancer Outcomes

Lymph Node Density Helps Predict Thyroid Cancer Outcomes

Papillary thyroid cancer patients with LND 0.19 have worse disease-specific, overall survival, researchers found.

Risk of Falls, Fractures Greater Among Elderly Patients with Cancer

Risk of Falls, Fractures Greater Among Elderly Patients with Cancer

Researchers conducted a geriatric assessment of 304 patients with cancer, then followed them in a 2-year study to determine the risk of fractures and falls in older patients.

Survival Predictors in Ovarian Cancer and Current Immunotherapeutic Strategies

Survival Predictors in Ovarian Cancer and Current Immunotherapeutic Strategies

Researchers have found 3 major predictors for survival: tumor infiltrating leukocytes (TIL), programmed death-ligand 1 (PD-L1) expression, and mutational burden.

Oral Microbiome Composition Linked to Esophageal Cancer Risk

Oral Microbiome Composition Linked to Esophageal Cancer Risk

Periodontal pathogen Tannerella forsythia linked to increased risk of esophageal adenocarcinoma

Prolonging Survival in MM: Daratumumab vs Pomalidomide Plus Dexamethasone

Prolonging Survival in MM: Daratumumab vs Pomalidomide Plus Dexamethasone

A head-to-head comparison investigated whether patients with multiple myeloma achieved greater prolongation in overall survival with daratumumab monotherapy or pomalidomide plus low-dose dexamethasone.

Active Surveillance Required Following Prostate Cancer Focal Ablation

Active Surveillance Required Following Prostate Cancer Focal Ablation

In a small but meaningful number of patients, Gleason pattern 4 disease missed by MRI and systematic biopsy is present outside the focal ablation zone.

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Examining the Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer

Breast cancer was previously thought to not be immunogenic in nature, but a subset of patients with breast cancer, primarily with triple negative disease, have exhibited robust levels of tumor infiltrating leukocytes.

Rare Cancer: An Underserved Oncology Area

Rare Cancer: An Underserved Oncology Area

As more rare cancers are identified, the need for rethinking approaches to research will become greater.

Cardiopulmonary Fitness Leads to Better Outcomes in Bladder Cancer Surgery

Cardiopulmonary Fitness Leads to Better Outcomes in Bladder Cancer Surgery

A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.

Present and Future Roles of PARP Inhibitors in Ovarian Cancer

Present and Future Roles of PARP Inhibitors in Ovarian Cancer

Ovarian cancer risk is known to be increased by BRCA1 and BRCA2 gene mutations, but recent developments have led researchers to believe there are several genes involved in homologous recombination-mediated DNA damage.

ASCO: Alcohol Is A Modifiable Risk Factor for Cancer

ASCO: Alcohol Is A Modifiable Risk Factor for Cancer

Seventy percent of Americans surveyed in this year's National Cancer Opinion Survey were unaware that alcohol is a well-established and modifiable risk factor for cancer, the authors noted.

Gefitinib Adjuvant Therapy Prolonged Disease-Free Survival in EGFR-Mutant NSCLC

Gefitinib Adjuvant Therapy Prolonged Disease-Free Survival in EGFR-Mutant NSCLC

Results of this randomized, phase 3 study comparing oral gefitinib with IV vinorelbine plus cisplatin revealed the effect of these regimens on disease-free survival in patients with exon 19 deletion or exon Leu585Arg NSCLC.

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Markers Identified for Cardiotoxicity Due to Chemotherapy for Breast Cancer

Biomarker analysis revealed markers for cardiotoxicity enabling early initiation of heart failure therapy in patients with breast cancer who were treated with chemotherapy.

Liquid Biopsies: An Emerging and Versatile Monitoring Modality in Lung Cancer

Liquid Biopsies: An Emerging and Versatile Monitoring Modality in Lung Cancer

In lung cancer, it is critical to evaluate the resistance mechanisms so appropriate treatment can be administered.

4R+3Dex Regimen May Lead to Durable Complete Response in Pediatric Chronic ITP

4R+3Dex Regimen May Lead to Durable Complete Response in Pediatric Chronic ITP

Young patients with chronic ITP may experience relapse within 5 years of completing therapy. In this study, investigators sought to determine if the 4R+3Dex regimen for chronic ITP would improve response rates in pediatric patients with the disease.

Testosterone Therapy May Lower Prostate Cancer Incidence

Testosterone Therapy May Lower Prostate Cancer Incidence

Hypogonadal men who received testosterone replacement therapy had a lower incidence of prostate cancer than those who did not, and their cancers were less severe.

FDA Grants Breakthrough Therapy Designation to bb2121 for Multiple Myeloma

FDA Grants Breakthrough Therapy Designation to bb2121 for Multiple Myeloma

Breakthrough Therapy Designation was granted for bb2121, a novel CAR T-cell therapy indicated for patients with multiple myeloma who have undergone previous treatments.

Survivors of Thyroid Cancer Have Higher Risk of Aging-related Morbidities

Survivors of Thyroid Cancer Have Higher Risk of Aging-related Morbidities

Using the statewide Utah Population Database, investigators sought to determine the long-term effects of thyroid cancer on survivors who were younger than 40 years at diagnosis.

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

Risk Factors for Brain Metastases in HER2+ Breast Cancer Identified in Analysis

A retrospective analysis presented at 2017 SABCS reveals the factors that indicate a higher risk of developing brain metastases for women with HER2+ breast cancer.

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.

Reduced Delayed Intensification Impacts Risk of Pediatric ALL Relapse

Reduced Delayed Intensification Impacts Risk of Pediatric ALL Relapse

Improved survival in pediatric patients with standard-risk ALL has shifted the focus toward reducing treatment burden and toxicity; therefore, researchers sought to determine the effects of reduced DI chemotherapy on relapse and survival.

Exercise May Mitigate Cardiotoxicity Associated With Doxorubicin Treatment

Exercise May Mitigate Cardiotoxicity Associated With Doxorubicin Treatment

Researchers injected Ewing sarcoma cells into mice to determine the effects of exercise on doxorubicin efficacy and treatment-related cardiotoxicity.

Mobile Health Apps Becoming More Popular Among Patients and Clinicians

Mobile Health Apps Becoming More Popular Among Patients and Clinicians

Clinicians and patients use this technology to monitor health, behaviors, and treatment outcomes.

ASCO Issues Statement Addressing Alcohol and Cancer

ASCO Issues Statement Addressing Alcohol and Cancer

Alcohol-related cancers account for 5.5 percent of all cancers treated annually worldwide.

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Axillary Lymph Node Dissection Predictive for Lymphedema in Breast Cancer

Researchers investigated the incidence of lymphedema on patients with breast cancer treated with TAC after axillary lymph node dissection (ALND), with or without radiotherapy, and its impact on quality of life for patients.

Drug Combination Does Not Extend Glioblastoma Survival

Drug Combination Does Not Extend Glioblastoma Survival

Lomustine plus bevacizumab may increase progression-free, but not overall, survival versus lomustine alone in progressive glioblastoma.

Vitamin D Supplementation is Recommended for Use in Young Patients With Sarcoma

Vitamin D Supplementation is Recommended for Use in Young Patients With Sarcoma

Just over half of patients in a standard therapy group had normal bone mineral density after a mean follow-up of 6 years; this contrasted with 93% of patients in a vitamin D supplementation group.

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Extended Adjuvant Therapy for Breast Cancer Improves 5-Year Disease-free Survival

Follow-up of a 2-year analysis of the ExteNET phase 3 study demonstrates the influence of 1-year extended adjuvant therapy with neratinib on relapse in patients with breast cancer 5.2 years after treatment.

Response to Anemia Treatment Differs in Lymphoma, Multiple Myeloma

Response to Anemia Treatment Differs in Lymphoma, Multiple Myeloma

In this analysis, researchers measured the impact and effectiveness of supportive treatments for moderate to severe anemia in patients with lymphoma or multiple myeloma, based on patient-reported outcomes.

Impact of Prostate Cancer Diagnosis, Treatment Choice on Quality of Life

Impact of Prostate Cancer Diagnosis, Treatment Choice on Quality of Life

The impact of prostate cancer treatment is well documented; however, in this study, researchers sought to determine the effect on health-related quality of life for patients from diagnosis through treatment planning to initiation of treatment.

Social, Psychiatric Variables Reduce Cognitive Functioning, QoL in HNC

Social, Psychiatric Variables Reduce Cognitive Functioning, QoL in HNC

Data on psychosocial and psychiatric variables of patients with HNC prior to treatment was analyzed to determine the extent of cognitive impairment and quality of life for patients with head and neck cancer, and its impact on patient outcomes.

Breast Cancer Recurrences Steady Following Therapy Cessation

Breast Cancer Recurrences Steady Following Therapy Cessation

Women with ER-positive BC who stop therapy after 5 years have steady recurrence rate up to 20 years afterward.

Compound in Teas, Peas, Soybeans May Increases Prostate Cancer Risk

Compound in Teas, Peas, Soybeans May Increases Prostate Cancer Risk

An analysis of an intervention arm of the PLCO Cancer Screening Trial evaluated the risk of prostate cancer relative to dietary consumption of isoflavones, a dietary compound found in some plant foods.

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