Additional PET/CT scans have value in follow-up of lung cancer patients

New research reveals a high value of scans that could lead to future change of reimbursement policies for follow-up positron emission tomography/computed tomography (PET/CT) studies in lung cancer. The study, published in the Journal of Nuclear Medicine (2015; doi:10.2967/jnumed.114.147884), establishes the value of fourth and subsequent follow-up PET/CT scans in clinical assessment and management change in patients with the disease.

According to the American Lung Association, lung cancer is the leading cancer killer in both men and women in the United States. Approximately 402,326 Americans living today have received a lung cancer diagnosis. In 2014, diagnoses of an estimated 224,210 new cases of lung cancer were expected, representing approximately 13% of all cancer diagnoses.

In the retrospective study, a total of 1,171 patients with biopsy-proven lung cancer who had positron emission tomography with a radioactive tracer (18F-FDG) were identified at a single tertiary center from 2001 to 2013. Among these, 85 patients (7.3%) had four or more follow up PET/CT scans with a total of 285 fourth and subsequent follow up PET/CT scans. Median follow up from the fourth scan was 31.4 months. The follow-up PET/CT scan results were correlated with clinical assessment and treatment changes.

Of the 285 fourth and subsequent follow-up PET/CT scans, 149 (52.28%) were interpreted as positive and 136 (47.7%) were interpreted as negative for recurrence or metastasis. A total of 47 (55.3%) patients died during the study period.

PET/CT identified recurrence or metastasis in 44.3% of scans performed without prior clinical suspicion and ruled out recurrence or metastasis in 24.2% of scans performed without prior clinical suspicion. The PET/CT scan resulted in treatment change in 28.1% (80/285) of the patients. In 20.4% (58/285) of scan times, new treatment was initiated; treatment was changed in 5.6% (16/285), and ongoing treatment was stopped in 2.1% (6/285).

"Although the value of FDG PET/CT has been established in the follow-up of patients with lung cancer, this study specifically looks at the value of the fourth and subsequent follow-up PET/CT studies, which has not been addressed in any prior studies," stated lead author Rathan Subramaniam, MD, PhD, of Johns Hopkins School of Medicine in Baltimore, Maryland.

"We now need to establish similar evidence for other human solid tumors," Subramaniam continued.

The study was performed in the context of the recent Center for Medicaid and Medicare Services declaration that only three FDG PET/CT scans will be covered under section 1862(a)(1)(A) when used to guide subsequent management of antitumor treatment strategy after completion of initial anticancer therapy. Coverage of any additional FDG PET/CT scans will be determined by local Medicare administrative contractors.

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