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VISTOGARD
Poisoning/overdose
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Drug Name:

VISTOGARD Rx

Generic Name and Formulations:
Uridine triacetate 10g; oral granules (95% w/w); per pkt; orange-flavored.

Company:
Wellstat Therapeutics Corp.

Therapeutic Use:

Indications for VISTOGARD:

Emergency treatment following a fluorouracil (5-FU) or capecitabine overdose regardless of the presence of symptoms or exhibits early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions within 96hrs following the end of 5-FU or capecitabine administration.

Limitations Of use:

Not for non-emergent treatment of adverse reactions associated with 5-FU or capecitabine. Safety and efficacy not been established for initiation >96hrs after 5-FU or capecitabine therapy.

Adult:

10g (1pkt) every 6hrs for 20 doses. Mix in 3–4oz of applesauce, pudding or yogurt and ingest within 30mins; do not chew granules. Drink at least 4oz of water. Also: can give via NG tube or G-tube if necessary: see full labeling.

Children:

Base dose on body surface area; see full labeling. 6.2g/m2 (max 10g) per dose every 6hrs for 20 doses. Mix in 3–4oz of applesauce, pudding or yogurt and ingest within 30mins; do not chew granules. Drink at least 4oz of water. Also: can give via NG tube or G-tube if necessary: see full labeling.

Warnings/Precautions:

Pregnancy. Nursing mothers.

Pharmacological Class:

Pyrimidine analog.

Adverse Reactions:

Vomiting, nausea, diarrhea.

Generic Availability:

NO

How Supplied:

Single-use packets—4, 20

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