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VENOFER
Anemias
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Drug Name:

VENOFER Rx

Generic Name and Formulations:
Iron (as sucrose) 20mg/mL; soln for IV inj or infusion; preservative-free.

Company:
American Regent, Inc.

Therapeutic Use:

Indications for VENOFER:

Iron deficiency anemia in chronic kidney disease.

Adult:

Give by slow IV inj (undiluted) or infusion (diluted). Usual total cumulative dose: 1000mg. Hemodialysis dependent: 100mg slow IV inj over 2–5 mins or infuse 100mg over at least 15 mins per consecutive session. Non-dialysis dependent: 200mg slow IV inj over 2–5 mins on 5 different occasions within a 14-day period; limited experience with IV infusion (see full labeling). Peritoneal dialysis dependent: Two infusions of 300mg over 1.5hrs 14 days apart, then one 400mg infusion over 2.5hrs 14 days later.

Children:

Not recommended.

Contraindications:

Anemia not caused by iron deficiency. Iron overload.

Warnings/Precautions:

Withhold therapy if tissue iron overload suspected. Monitor hemoglobin, hematocrit, serum ferritin, transferrin saturation; obtain serum iron values 48 hours after dosing. Pregnancy (Cat. B). Nursing mothers.

Interactions:

May reduce absorption of concomitant oral iron preparations.

Pharmacological Class:

Hematinic.

Adverse Reactions:

Hypotension (esp. by IV infusion), hypertension, muscle cramps, GI upset, headache, dizziness, chest pain, graft complications, dysgeusia, pruritus, edema, constipation; rare: hypersensitivity reactions (may be severe).

How Supplied:

Single-dose vials (100mg/5mL)—1, 10, 25; 200mg/10mL—1, 5,10

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