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VAXCHORA
Vaccines
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Drug Name:

VAXCHORA Rx

Generic Name and Formulations:
Cholera vaccine, live attenuated (V. cholerae strain CVD 103-HgR); 100mL per single dose; susp for oral administration after reconstitution.

Company:
PaxVax Corporation

Therapeutic Use:

Indications for VAXCHORA:

Immunization against disease caused by Vibrio cholerae serogroup 01 in adults 18–64 years of age traveling to cholera-affected areas.

Limitations Of use:

Efficacy not established in persons living in cholera-affected areas or persons with pre-existing immunity due to previous exposure to V. cholerae or receipt of a cholera vaccine. Not shown to protect against disease caused by V. cholerae serogroup 0139 or other non-01 serogroups.

Adult:

For oral administration only. Avoid food or drink for 60mins before and after administration. ≥18yrs: Give single oral dose a minimum of 10 days before potential cholera exposure.

Children:

<18yrs: not established.

Contraindications:

Severe allergic reaction to any previous cholera vaccine.

Warnings/Precautions:

Immunocompromised. Considering whether to administer to individuals with immunocompromised close contacts. Elderly. Pregnancy.

Interactions:

Avoid use within 14 days of systemic antibiotics. Give vaccine ≥10 days prior to antimalarial prophylaxis with chloroquine. Concomitant immunosuppressive therapy (eg, irradiation, antimetabolites, alkylating agents, cytotoxic drugs, high-dose corticosteroids): may get suboptimal response.

Pharmacological Class:

Cholera vaccine.

Adverse Reactions:

Tiredness, headache, abdominal pain, nausea/vomiting, lack of appetite, diarrhea.

Note:

To enroll patients in the pregnancy exposure registry call (800) 533-5899.

Generic Availability:

NO

How Supplied:

Single-dose carton—2 packets (buffer component + active component)

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