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VALIUM
Addiction/dependence
Anxiety/OCD
Muscle spasms
Seizure disorders
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Drug Name:

VALIUM CIV

Generic Name and Formulations:
Diazepam 2mg, 5mg, 10mg; scored tabs.

Company:
Genentech, Inc.

Therapeutic Use:

Indications for VALIUM:

Acute alcohol withdrawal.

Adult:

Initially 10mg 3–4 times during the first 24hrs, then reduce to 5mg 3–4 times daily as needed.

Children:

Not established.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity.

How Supplied:

Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier

Indications for VALIUM:

Anxiety.

Adult:

2–10mg 2–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

<6months: See Contraindications. ≥6months: initially 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Injection

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity.

How Supplied:

Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier

Indications for VALIUM:

Skeletal muscle spasm.

Adult:

2–10mg 3–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

<6months: See Contraindications. ≥6months: initially 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Injection

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity.

How Supplied:

Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier

Indications for VALIUM:

Adjunct in convulsive disorders.

Adult:

2–10mg 2–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually.

Children:

<6months: See Contraindications. ≥6months: initially 1–2.5mg 3–4 times daily; increase gradually.

Contraindications:

Children <6months. Myasthenia gravis. Severe respiratory insufficiency. Severe hepatic insufficiency. Sleep apnea syndrome. Acute narrow-angle glaucoma. Untreated open angle glaucoma.

Warnings/Precautions:

Risks from concomitant use with opioids; see Interactions. Monitor for CNS depressant effects. Discontinue if paradoxical reaction occurs. Respiratory insufficiency. Depression. Suicidal tendencies. Drug or alcohol abuse. May increase severity of seizures. Renal or hepatic impairment. Avoid abrupt cessation. Reevaluate periodically. Monitor blood counts, liver function. Inj: not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Elderly. Debilitated. Labor & delivery. Psychosis, pregnancy, nursing mothers: not recommended.

Interactions:

Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Potentiates CNS depression with alcohol, other CNS depressants (eg, phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, antihistamines, barbiturates, MAOIs, other antidepressants). Potentiated by CYP3A or CYP2C19 inhibitors (eg, cimetidine, fluoxetine, fluvoxamine, ketoconazole, omeprazole). May affect or be affected by phenytoin.

See Also:

Diazepam Injection

Pharmacological Class:

Benzodiazepine.

Adverse Reactions:

Drowsiness, fatigue, muscle weakness, ataxia, CNS effects, GI disturbances, hypotension, salivation changes, neutropenia, jaundice; paradoxical excitement. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, local irritation, swelling, tonic status epilepticus (when treating petit mal), propylene glycol toxicity.

How Supplied:

Tabs 2mg—100; Tabs 5mg, 10mg—100, 500; Vials (10mL)—contact supplier

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