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UROXATRAL
Benign prostatic hyperplasia/urinary retention
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Drug Name:

UROXATRAL Rx

Generic Name and Formulations:
Alfuzosin (as HCl) 10mg; ext-rel tabs.

Company:
Covis Pharmaceuticals, Inc.

Therapeutic Use:

Indications for UROXATRAL:

Benign prostatic hyperplasia (BPH). Limitations of use: not for use in children or for the treatment of hypertension.

Adult:

Swallow whole. Take immediately after same meal each day. 10mg once daily.

Children:

Not applicable.

Contraindications:

Concomitant potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir). Moderate or severe hepatic insufficiency.

Warnings/Precautions:

Not for use in women. Discontinue if angina develops or worsens. Severe renal insufficiency (CrCl <30mL/min). Hypotension. Mild hepatic impairment. History of QT interval prolongation. Exclude prostate cancer prior to initiation. Cataract surgery (intraoperative floppy iris syndrome possible). Pregnancy (Cat.B).

Interactions:

See Contraindications. Do not use with other α-blockers. Increased hypotension with concomitant nitrates, PDE5 inhibitors, other antihypertensives. Potentiates and is potentiated by cimetidine. Potentiates cardiovascular effects of atenolol. Caution with drugs that prolong QT interval.

Pharmacological Class:

Alpha-1 blocker.

Adverse Reactions:

Dizziness, upper respiratory tract infection, headache, fatigue; postural hypotension, syncope; rare: priapism.

How Supplied:

Tabs—100

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