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TYGACIL
Bacterial infections
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Drug Name:

TYGACIL Rx

Generic Name and Formulations:
Tigecycline 50mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for TYGACIL:

Susceptible complicated skin and skin structure and intra-abdominal infections. Community-acquired bacterial pneumonia (CABP). Limitations of use: not for treating diabetic foot infection, hospital-acquired or ventilator-associated pneumonia.

Adult:

≥18yrs: Give by IV infusion over 30–60 mins. 100mg once, then 50mg every 12hrs. Skin, skin structure, and intra-abdominal infections: treat for 5–14 days. CABP: treat for 7–14 days. Severe hepatic impairment (Child Pugh C): 100mg once, then 25mg every 12hrs.

Children:

<18yrs: not recommended. See full labeling for suggested dosages when no alternative antibacterial drugs are available.

Warnings/Precautions:

Risk of increase in all-cause mortality; reserve for use when alternatives are not suitable. Monitor for hepatic dysfunction and pancreatitis; consider discontinuing if occurs. Ventilator-associated pneumonia. Complicated intra-abdominal infections secondary to intestinal perforation: avoid monotherapy (sepsis/septic shock may develop). Avoid during tooth development; may cause permanent discoloration of the teeth. Severe hepatic impairment. Pregnancy (Cat.D): not recommended. Nursing mothers.

Interactions:

Monitor warfarin. May antagonize oral contraceptives.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Nausea, vomiting, diarrhea, abdominal pain, headache, increased SGPT, inj site reactions, photosensitivity, pseudotumor cerebri; pancreatitis, superinfection, anaphylaxis, C. difficile-associated diarrhea (evaluate if occurs).

How Supplied:

Single-use vials (5mL, 10mL)—10

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