Tumors

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties, according to a recent study.

Protein Identified That Could Prevent Tumor Growth in Cervical Cancer

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A protein has been identified that can inhibit cellular inflammation, a major contributor to the growth of cervical cancer.

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

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The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.

Tumor Markers (Fact Sheet)

Tumor Markers (Fact Sheet)

This fact sheet explains tumor markers and their current use in cancer care.

Novel Approach Harnesses Dendritic Cells to Treat Glioma

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A next-generation immunotherapy may offer hope for treating high-grade glioma, an aggressive form of brain cancer that is notoriously hard to treat.

Internal Mammary Lymph Nodes Discovered With MRI Likely to Be Benign

Internal Mammary Lymph Nodes Discovered With MRI Likely to Be Benign

Internal mammary lymph nodes (IMLNs) identified at implant-protocol breast magnetic resonance imaging (MRI) are more likely to be benign than malignant.

Breast Conservation Surgery as Effective as Mastectomy for Some Large Breast Tumors

Breast Conservation Surgery as Effective as Mastectomy for Some Large Breast Tumors

Findings suggest doctors shouldn't automatically rule out less invasive surgery plus radiation for some larger breast tumors.

Model shows how cancerous tumors manipulate blood-vessel growth

Model shows how cancerous tumors manipulate blood-vessel growth

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A detailed simulation has made a more detailed examination of how tumors manipulate blood-vessel growth to their advantage.

Response to new drug in patients with lymphomas and advanced solid tumors

Patients with B-cell non-Hodgkin lymphomas and advanced solid tumors have responded to a new drug that is being tested for the first time in humans in a phase I clinical trial.

Antimalarial inhibits tumor growth and metastases

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A recent study has demonstrated that the malaria drug chloroquine normalizes the abnormal blood vessels in tumors, which can aid in blocking cancer cell dissemination and metastasis.

New nanoparticle could improve MRI scanning for cancer diagnosis

New nanoparticle could improve MRI scanning for cancer diagnosis

A research team has created a new, self-assembling nanoparticle that can increase the effectiveness of magnetic resonance imaging (MRI) cancer detection.

Common clinical practice described for incompletely resected lung cancer

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A landmark survey of more than 700 specialists provides crucial real-world insight into the treatments that most oncologists choose for lung cancer patients whose tumor has been incompletely resected.

New type of cancer has been discovered

New type of cancer has been discovered

An abnormal yet recurring chromosomal mismatch causes a little-known facial tumour that is more common in women.

Tumor size is strongest variable in patient response to promising melanoma drug

Tumor size is strongest variable in patient response to promising melanoma drug

In examining why some advanced melanoma patients respond so well to the experimental immunotherapy MK-3475, while others have a less robust response, researchers at Mayo Clinic in Florida found that the size of tumors before treatment was the strongest variable.

Metastatic tumor sites predict OS in castration resistant prostate cancer

Metastatic tumor sites predict OS in castration resistant prostate cancer

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The site of metastatic tumors powerfully predicts overall survival (OS) among men with metastatic castration resistant prostate cancer (mCRPC), confirms a meta-analysis presented at the 2014 American Society of Clinical Oncology Annual Meeting.

'Excellent' survival in biology-based pediatric neuroblastoma treatment reduction

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Tumor biology-based therapy offers excellent outcomes among children with intermediate risk neuroblastoma, according to results from a prospective phase 3 reduction of therapy study.

Small increase in lung cancer risk after radiotherapy for breast cancer

Small increase in lung cancer risk after radiotherapy for breast cancer

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Women who have radiotherapy for breast cancer have a small but significantly increased risk of subsequently developing a primary lung tumor.

Interval tumors found in six percent of colorectal cancer cases

Interval tumors found in six percent of colorectal cancer cases

Interval cancers more likely to be earlier stage, proximal, have lower risk of death

Treatment priorities set for early breast tumors

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A team of stakeholders has detailed research priorities necessary to address gaps in knowledge about early breast tumors in women.

Antioxidants increase lung tumor growth in mice

Antioxidants increase lung tumor growth in mice

Supplementation with antioxidants markedly increases tumor cell proliferation and tumor growth in mice, researchers found.

Radiation therapy provides tumor control in bladder cancer

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Standard and reduced high-dose volume RT for muscle-invasive bladder cancer provides comparable tumor control and decreased late toxicity compared with surgery, according to a new study.

Shorter radiotherapy schedules may compensate for between-dose tumor cell growth

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Researchers have estimated the daily dose of radiation therapy that is wasted in compensating for cancer cell growth that occurs overnight and during weekends in patients with early breast cancer, which could shorten radiation therapy schedules.

Immune system harnessed to fight pancreatic cancer

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Substantial tumor regressions among some patients with advanced pancreatic cancer occurred in a recent clinical trial that paired the standard chemotherapy for pancreatic cancer, gemcitabine, with an agonist CD40 antibody.

Adolescent radiotherapy increases likelihood of later estrogen-negative breast tumors

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Increased stem cell self-renewal and subsequent mammary stem cell enrichment are the culprits of breast cancer that develops later among women who were exposed to ionizing radiation as young women, according to a new study.

First randomized trial of targeted cancer medicine in all tumor types

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The SHIVA trial is the first randomized trial to look at patient outcomes after treatments were chosen based on individual molecular profiles of each person's tumor.

Tumors subtyped by shared genetic effects

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Cancer tumors almost never share the exact same genetic mutations, which is a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments.

Tumor suppressor may actually fuel aggressive leukemia

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New research suggests that blocking a protein normally credited with suppressing leukemia may be a promising therapeutic strategy for an aggressive form of the disease called acute myeloid leukemia.

Promising therapeutic target for meningioma brain tumors

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A specific protein has been found in nearly 100% of high-grade meningiomas, which is the most common form of brain tumor. This finding suggests a new target for therapies for a cancer that does not respond to current chemotherapy.

Inflammatory protein converts glioblastoma cells into the most aggressive version

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A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy.

Some breast cancer cells primed to prosper after metastasis to bone

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Some metastasizing breast cancer cells express genes that make them more likely to prosper in bone tissue, according to new research.

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