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TRIOSTAT
Thyroid disease
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Drug Name:

TRIOSTAT Rx

Generic Name and Formulations:
Liothyronine (as sodium) 10mcg/mL; soln for IV inj.

Company:
JHP Pharmaceuticals

Therapeutic Use:

Indications for TRIOSTAT:

Myxedema coma/precoma.

Adult:

Give with glucocorticoids. Allow 4–12 hours between doses. Initially 25–50mcg. Cardiovascular disease: initially 10–20mcg. Usual range: 65–100mcg daily. Change to oral therapy as soon as possible: start tabs at low dose and increase gradually; discontinue IV gradually.

Children:

Not recommended.

Contraindications:

Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. Artificial rewarming.

Warnings/Precautions:

Not for treatment of obesity. Cardiovascular disease, angina, elderly: initiate therapy at 10–20micrograms. Severe and prolonged hypothyroidism. Fluid therapy. Adrenocortical insufficiency. Pregnancy (Cat.A). Nursing mothers.

Interactions:

Potentiates digitalis toxicity, tricyclic antidepressants, sympathomimetics (e.g., anorectics). May increase risk of coronary insufficiency with vasopressors. Monitor oral anticoagulants, hypoglycemics. Estrogens affect thyroid function tests. May be potentiated by tricyclic antidepressants. Hypertension, tachycardia with ketamine.

Pharmacological Class:

T3 (synthetic).

Adverse Reactions:

Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, MI, angina, CHF, hypertension, twitching.

How Supplied:

Vials (1mL)—6

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