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TRIGLIDE
Hyperlipoproteinemias
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Drug Name:

TRIGLIDE Rx

Generic Name and Formulations:
Fenofibrate 50mg, 160mg; tabs.

Company:
Shionogi, Inc.

Therapeutic Use:

Indications for TRIGLIDE:

Adjunct to diet in hypertriglyceridemia (Types IV and V), to reduce elevated total-C, LDL-C, apo B, TG, and to increase HDL-C in primary hypercholesterolemia and mixed dyslipidemia (Types IIa and IIb).

Adult:

Hypertriglyceridemia: 50–160mg once daily; adjust at 4–8 week intervals. Hypercholesterolemia, dyslipidemia: 160mg/day. Renal impairment or elderly: initially 50mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not recommended.

Contraindications:

Hepatic dysfunction. Primary biliary cirrhosis. Severe renal dysfunction. Gallbladder disease. Nursing mothers.

Warnings/Precautions:

Renal impairment. Monitor CBCs for first year; monitor liver function; discontinue if ALT (SGPT) levels >3xULN persist. Discontinue if markedly elevated CPK levels, myopathy, severely depressed HDL-C levels, or gallstones occur. Pregnancy (Cat.C).

Interactions:

Avoid statins. Potentiates oral anticoagulants (monitor). Allow at least 1 hour before or 4–6 hours after bile acid sequestrants. Caution with colchicine, immunosuppressants (eg, cyclosporine, tacrolimus), other nephrotoxic drugs.

Pharmacological Class:

Fibrate.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, respiratory or GI effects, myopathy, cholelithiasis, pancreatitis, increased BUN or creatinine, rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias, paradoxical decrease in HDL-C levels.

How Supplied:

Tabs—30

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