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TREMFYA
Psoriasis
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Drug Name:

TREMFYA Rx

Generic Name and Formulations:
Guselkumab 100mg/mL; soln for SC inj; preservative-free.

Company:
Janssen Biotech, Inc.

Therapeutic Use:

Indications for TREMFYA:

Moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Adult:

≥18yrs: 100mg by SC inj at Weeks 0 and 4, then every 8 weeks thereafter.

Children:

<18yrs: not established.

Warnings/Precautions:

Use under physician supervision. May increase risk of infections. Chronic or history of recurrent infection: consider the risks and benefits. If a serious infection develops or is not responding to standard therapy, monitor closely and discontinue until resolves. Evaluate for tuberculosis (TB) infection and treat latent TB prior to initiating. Monitor for signs/symptoms of active TB during and after therapy. Patients with active TB infection: do not initiate. History of latent or active TB (without confirmed adequate treatment); consider anti-TB therapy prior to initiation. Consider completion of all age appropriate immunizations according to current guidelines before starting therapy. Pregnancy. Nursing mothers.

Interactions:

Concomitant live vaccines: not recommended. Concomitant CYP450 substrates with narrow therapeutic index: monitor and adjust dose as needed.

Pharmacological Class:

Interleukin-23 antagonist.

Adverse Reactions:

Upper respiratory infections, headache, inj site reactions, arthralgia, diarrhea, gastroenteritis, tinea infections, herpes simplex infections.

Generic Availability:

NO

How Supplied:

Single-dose prefilled syringe—1

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