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TRECATOR
Tuberculosis
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Drug Name:

TRECATOR Rx

Generic Name and Formulations:
Ethionamide 250mg; tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for TRECATOR:

Adjunct in tuberculosis, when INH and rifampin are not appropriate.

Adult:

Give with meals to minimize GI upset. Initially 250mg/day in 1–4 divided doses; titrate to highest tolerated dose (see full labeling). Usual range: 15–20mg/kg daily; max 1g/day.

Children:

Give with meals to minimize GI upset. 10–20mg/kg in 2–3 divided doses, or 15mg/kg once daily.

Contraindications:

Severe hepatic impairment.

Warnings/Precautions:

Confirm presence of susceptible bacterial infection before initiating therapy. Re-titrate when switching from Trecator SC sugar-coated tabs. Give with pyridoxine. Diabetes. Do baseline and periodic blood glucose levels, eye exams (including ophthalmoscopy). Monitor thyroid function. Obtain SGOT and SGPT before and monthly; suspend if levels increase. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Avoid alcohol. Potentiates other antituberculars. Convulsions with cycloserine.

Adverse Reactions:

GI upset, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, liver dysfunction, psychosis, drowsiness, dizziness, restlessness, headache, postural hypotension, hypoglycemia, gynecomastia, impotence, acne; rarely; peripheral/optic neuritis, visual disturbances, pellagra, thrombocytopenia.

Note:

Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet which may result in higher peak levels.

How Supplied:

Tabs—100

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