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TRADJENTA
Diabetes
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Drug Name:

TRADJENTA Rx

Generic Name and Formulations:
Linagliptin 5mg; tabs.

Company:
Boehringer Ingelheim and Lilly

Therapeutic Use:

Indications for TRADJENTA:

Adjunct to diet and exercise in type 2 diabetes mellitus, as monotherapy or combination therapy.

Limitations Of use:

Not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with a history of pancreatitis.

Adult:

5mg once daily.

Children:

<18yrs: not established.

Warnings/Precautions:

Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, severe joint pain, or bullous pemphigoid; discontinue if suspected or occurs. History of angioedema to other DPP-4 inhibitors. Pregnancy. Nursing mothers.

Interactions:

Antagonized by strong P-gp or CYP3A4 inducers (eg, rifampin); consider alternatives to linagliptin if used in combination. May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.

Pharmacological Class:

Dipeptidyl peptidase-4 (DPP-4) inhibitor.

Adverse Reactions:

Nasopharyngitis, diarrhea, cough, hypoglycemia; hypersensitivity reactions (eg, anaphylaxis, urticaria, angioedema, exfoliative skin conditions, bronchial hyperreactivity), myalgia, pancreatitis, severe and disabling arthralgia, bullous pemphigoid.

Metabolism:

Extensively unchanged.

Elimination:

Enterohepatic (80%), renal (5%).

Generic Availability:

NO

How Supplied:

Tabs—30, 90

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