ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

TOTECT
Cytoprotective and supportive care agents
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

TOTECT Rx

Generic Name and Formulations:
Dexrazoxane 500mg; per vial; pwd for IV infusion after reconstitution and dilution; preservative-free.

Company:
Biocodex USA

Therapeutic Use:

Indications for TOTECT:

To treat extravasation resulting from IV anthracycline chemotherapy.

Adult:

Give once daily for 3 consecutive days by IV infusion over 1–2 hours. Initiate 1st dose as soon as possible and within 1st 6 hours after extravasation. Days 1 and 2: 1000mg/m2; max 2000mg. Day 3: 500mg/m2; max 1000mg. Renal impairment (CrCl <40mL/min): reduce dose by 50%.

Children:

Not recommended.

Warnings/Precautions:

Renal or hepatic impairment (monitor liver enzymes). Monitor for myelosuppression; obtain blood counts periodically. Elderly. Labor & delivery. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid dimethylsulfoxide (DMSO). Caution with concurrent cytotoxic chemotherapy (additive cytotoxicity).

Pharmacological Class:

Detoxifying agent.

Adverse Reactions:

Inj site reactions, GI upset, stomatitis, leukopenia, neutropenia, thrombocytopenia, elevated liver enzymes, pyrexia, infections.

How Supplied:

Kit—10 single-use vials (w. diluent)

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs