ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

TOBI
Bacterial infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

TOBI Rx

Generic Name and Formulations:
Tobramycin 300mg/5mL; amps; soln for inhalation; preservative-free.

Company:
Novartis Pharmaceuticals Corp

Therapeutic Use:

Indications for TOBI:

Management of cystic fibrosis patients with P. aeruginosa.

Adults and Children:

<6yrs: not studied. Use the correct nebulizer/compressor. Administer by inhalation over a 15-minute period. Give in alternate 28-day cycles (28 days on, 28 days off). ≥6yrs: 300mg (1 amp) twice daily, as close to every 12hrs as possible (must be at least 6hrs apart). Give last when using multiple inhalation therapies.

Warnings/Precautions:

Safety and efficacy have not been demonstrated in patients <6yrs, in those with FEV1 <25% or >75% predicted, or patients colonized with B. cepacia. Known or suspected auditory, vestibular, renal, or neuromuscular dysfunction. Myasthenia gravis. Parkinson's disease. Consider performing an audiogram at baseline (esp. at risk of auditory dysfunction). Monitor for high frequency hearing loss if tinnitus occurs. Monitor serum tobramycin levels in renal dysfunction patients or if treated with concomitant IV tobramycin. Discontinue if nephrotoxicity occurs; may restart when serum tobramycin <2µg/mL. Monitor renal function as needed. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Concomitant ethacrynic acid, furosemide, urea, IV mannitol: not recommended. Diuretics may increase toxicity. Avoid concurrent or sequential use of other oto-, neuro-, or nephrotoxic drugs. Do not mix in nebulizer with dornase alfa.

Pharmacological Class:

Aminoglycoside.

Adverse Reactions:

Voice alteration, tinnitus (follow-up if occurs), bronchospasm.

How Supplied:

Single-use amps (5mL)—56

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs