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Timolol Maleate
Glaucoma
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Drug Name:

Timolol Maleate Rx

Generic Name and Formulations:
Timolol (as maleate) 0.25%, 0.5%; oph soln; contains benzalkonium chloride.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Timolol Maleate:

Open-angle glaucoma.

Adults and Children:

<2yrs: not established. ≥2yrs: Initially 1 drop of 0.25% twice daily; max 1 drop of 0.5% twice daily. Transfer from other drugs, see full labeling.

Contraindications:

Greater than 1st-degree AV block. Uncompensated cardiac failure. Cardiogenic shock. Sinus bradycardia. History of bronchospasm. Bronchial asthma. Severe COPD. As sole agent in narrow-angle glaucoma. All contact lenses (Timoptic-XE); soft contact lenses (Timoptic and Timoptic-XE).

Warnings/Precautions:

Poor cardiac reserve should be controlled with digitalis and diuretics. Diabetes. Presbyopia. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Measure intraocular pressure after 4 weeks of treatment. Avoid abrupt cessation. Discontinue at 1st sign of cardiac failure and before surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

May potentiate systemic β-blockers, reserpine, hypoglycemics and mydriatic effect of topical epinephrine. Additive cardiac and pulmonary effects with anticholinesterase miotics. May antagonize bronchodilation from β-adrenergic agonists. May cause conduction defects with calcium channel blockers, digoxin.

See Also:

TIMOPTIC OCUDOSE

TIMOPTIC-XE

Pharmacological Class:

Noncardioselective beta-blocker.

Adverse Reactions:

Ocular irritation, sensitization, rash, dizziness, blurred vision, corneal anesthesia, headache, GI upset, paresthesias. Systemic β-blocker effects (bradycardia, arrhythmias, hypotension, bronchospasm, heart failure). Aphakic maculopathy (rare).

Note:

Formerly known under the brand name Timoptic.

Generic Availability:

YES

How Supplied:

Soln—contact supplier; Ocudose—60; XE—2.5mL, 5mL

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