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TIMENTIN
Bacterial infections
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Drug Name:

TIMENTIN Rx

Generic Name and Formulations:
Ticarcillin (as disodium) 3g, clavulanate (as potassium) 0.1g; IV inj; sodium content 4.75mEq/g of ticarcillin; potassium content 0.15mEq/g of Timentin.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for TIMENTIN:

Susceptible bacterial septicemia (adults only), lower respiratory, bone and joint, skin and skin structure, urinary tract, gynecologic and intraabdominal infections.

Adult:

By IV infusion over 30 minutes. >60kg: Systemic and UTI: 3.1g every 4–6 hours. Gynecologic: moderate: 200mg/kg/day of ticarcillin in divided doses every 6 hours; severe: 300mg/kg/day in divided doses every 4 hours. <60kg: 200–300mg/kg/day in divided doses every 4–6 hours. Renal impairment: reduce dose; see literature.

Children:

<3months: not recommended. Give by IV infusion over 30 minutes. ≥3months: (<60kg): mild-to-moderate infections: 200mg/kg per day of ticarcillin in equal divided doses every 6 hrs: severe infections: 300mg/kg per day of ticarcillin in equal divided doses every 4 hours. ≥3months (≥60kg): mild-to-moderate infections: 3.1g every 6 hrs; severe infections: 3.1g every 4 hours. Renal impairment: reduce dose; see literature.

Warnings/Precautions:

Cephalosporin, imipenem or other allergy. Not for use in children for septicemia or H. influenzae type b infections. Heart disease. Sodium restricted diets. Monitor serum electrolytes (esp. potassium) and renal, hepatic, hematopoietic function during prolonged therapy. Discontinue if bleeding problems occur and treat. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Probenecid increases ticarcillin levels. May cause false (+) Coomb's test.

Pharmacological Class:

Antipseudomonal penicillin + β-lactamase inhibitor.

Adverse Reactions:

Inj site reactions, rash, pruritus, drug fever, GI upset, blood dyscrasias, hemorrhage, hypokalemia, superinfection, anaphylaxis, CNS stimulation, elevated liver enzymes.

How Supplied:

Vials (3.1g)—1

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