TAVI Beneficial in Severe Aortic Stenosis

Share this article:
TAVI Beneficial in Severe Aortic Stenosis
TAVI Beneficial in Severe Aortic Stenosis

(HealthDay News) – While all-cause mortality is high in low-flow, low-gradient aortic stenosis patients receiving transcatheter aortic valve implantation (TAVI), surviving patients show significant improvements.

Michael Gotzmann, MD, from the BG University-Hospital Bergmannsheil in Bochum, Germany, and colleagues studied 167 consecutive patients with native severe aortic stenosis and an excessive operative risk who underwent TAVI. Of these, 15 patients presented with low-flow, low-gradient aortic stenosis (aortic valve area <1cm², left ventricular (LV) ejection fraction <40%, aortic mean gradient <40mmHg). The CoreValve prosthesis 18-F-generation (Medtronic) was inserted retrograde. Six months following the procedure, clinical follow-up and echocardiography were performed.

The researchers found that patients with low-flow, low-gradient aortic stenosis (mean LV ejection fraction 32 ± 6% and a mean aortic gradient 27 ± 7mmHg) had significantly higher all-cause mortality six months after TAVI compared to patients without low-flow, low-gradient aortic stenosis (33 vs.13%). In the surviving 10 patients with low-flow, low-gradient aortic stenosis, LV ejection fraction significantly increased (34 ± 6% before vs. 46 ± 11% six months after TAVI) and the patient covered significantly more distance in the six-minute walk test (218 ± 102m before vs. 288 ± 129m six months after TAVI).

"Our study suggests that TAVI is feasible in patients with severe comorbidities and low-flow, low-gradient aortic stenosis," the authors write.

One author is a physician proctor for CoreValve (Medtronic).

Abstract
Full Text (subscription or payment may be required)

Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs