Targeted Therapy

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

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Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Targeting microRNA may benefit some patients with ovarian and breast cancer

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Researchers believe they may have found a molecule-based approach to halting the destructive quality of the 3q26.2 amplicon, a frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.

Oral inhibitor shows clinical activity in poor-prognosis acute myelogenous leukemia (AML)

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An oral targeted agent has shown encouraging activity and limited side effects in patients with treatment-resistant or relapsed acute myelogenous leukemia (AML), according to research.

New kind of targeted drug is promising for patients with leukemia

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Patients with advanced leukemia, when treated with a new type of cancer therapy that blocks mutated IDH2 protein, showed dramatic results in a clinical trial.

Vaccine targeting breast cancers produced robust immune response

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A DNA vaccine targeting the breast cancer-associated antigen mammaglobin-A was proven safe and found to effectively elicit immune responses in women with metastatic breast cancer, according to a new study.

Evolutionary principles used to model cancer mutations and discover potential therapeutic targets

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Researchers are now examining specific genetic mutations from a more Darwinian standpoint, to aid cancer treatment.

Evolving roles for oncology nurses: Biospecimen collection

Evolving roles for oncology nurses: Biospecimen collection

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Personalized medicine is changing oncology nursing. This primer explains best practices for collecting and preparing biospecimens used to guide therapy.

The Promise of Precision Cancer Treatment (Infographic)

The Promise of Precision Cancer Treatment (Infographic)

Precision cancer treatment examines tumors on a genetic level with an aim to uncover the cause of the cancer's growth.

Targeting a unique receptor promising for glioblastoma multiforme

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Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.

Improved response rate and survival with dabrafenib plus trametinib versus vemurafenib alone

Targeting BRAF V600E/K mutation-positive melanoma with dabrafenib in combination with trametinib achieves longer overall survival and impoved response rates, compared to treatment with vemurafenib alone.

Crizotinib treatment effective against ROS1-positive lung cancer

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Treatment with the drug crizotinib has been effective for stopping lung tumor growth driven by rearrangements of the ROS1 gene.

Gene expression patterns revealed in pancreatic circulation tumor cells

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An analysis of circulating tumor cells (CTCs) in a pancreatic cancer model identified several different classes of CTCs and found unexpected factors that may prove to be future targets for improved treatment.

Targeted combination therapy halts disease and extends life in advanced melanoma

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A targeted combination drug therapy has shown efficacy for metastatic melanoma, showing reduction in both mortality and disease progression.

AACR: Targeted drugs and prevention reduce cancer mortality

AACR: Targeted drugs and prevention reduce cancer mortality

About 14.5 million U.S. cancer survivors are alive today, but aging population and increasing obesity threaten progress.

Integrated approach to pinpoint genetic drivers of cancer uncovers viable targets for breast cancer therapy

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Researchers have developed a new integrated approach to identify the genetic drivers of cancer, uncovering eight genes necessary for cell proliferation in breast cancer.

EGFR mutations in circulating tumor DNA (ctDNA) can be used in place of tumor tissue in non-small cell lung cancer (NSCLC) diagnostics

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Epidermal growth factor receptor mutations found in ctDNA in the plasma of patients with advanced non-small cell lung cancer correlates well with the EGFR mutations from patient-matched tumor tissue DNA.

Finding keys to drug therapy resistance in glioblastoma

Finding keys to drug therapy resistance in glioblastoma

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Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.

Repurposing antidepressant may target new medulloblastoma pathway

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New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.

Gene likely to promote childhood cancers pinpointed

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Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.

Drug target identified for common childhood blood cancer

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In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers report that they have identified a possible new drug target for treating the disease.

Possible target for immunotherapy in early stage breast cancer identified

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A new molecular analysis tool accurately detected the level of an important target for immunotherapy in early stage breast cancers.

New analysis method finds possible therapeutic targets for drug resistant melanoma

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Researchers have developed a new way to identify possible therapeutic targets for patients with drug resistant melanoma.

Cat parasite helps combat cancer

Cat parasite helps combat cancer

Research has shown that a mutated form of T. gondii may help galvanize the human immune system to fight cancer.

Protein inhibition opens door for pancreatic cancer treatment

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The protein galectin-1 has been identified as a possible therapeutic target for pancreatic cancer; new research has demonstrated that inhibiting this protein in mice with pancreatic cancer increased survival by 20%.

New nanoparticle could improve MRI scanning for cancer diagnosis

New nanoparticle could improve MRI scanning for cancer diagnosis

A research team has created a new, self-assembling nanoparticle that can increase the effectiveness of magnetic resonance imaging (MRI) cancer detection.

Managing follicular lymphoma

Managing follicular lymphoma

Changes in how follicular lymphoma is managed have led to substantial improvement in prognosis and over all survival for patients with the disease.

DNA origami can deliver targeted cancer drugs

DNA origami can deliver targeted cancer drugs

Scientists have shown that DNA origami can be used for the targeted delivery of cancer drugs to tumor cells in mice.

New mutations found in common lung cancer subtype

New mutations found in common lung cancer subtype

Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

A new target for aggressive bladder cancer found

A new target for aggressive bladder cancer found

An international team of scientists have discovered a faulty process in certain bladder cancers that could point to new ways to treat patients with an aggressive form of the disease.

Way to diagnose aggressiveness of oral cancer found

Way to diagnose aggressiveness of oral cancer found

Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment.

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