Targeted Therapy

Proton therapy for esophageal cancer has fewer side effects than older radiation therapies

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New research indicates that treating patients with esophageal cancer with proton therapy produces fewer toxic side effects than utilizing older radiation therapies.

Injected immune cells found safe for patients with multiple myeloma

Injected immune cells found safe for patients with multiple myeloma

Researchers have reported safely using immune cells grown from patients' own bone marrow to treat multiple myeloma, according to clinical trial data.

ASCO: New strategies promising for chronic-lymphocytic leukemia and non-Hodgkin lymphoma

ASCO: New strategies promising for chronic-lymphocytic leukemia and non-Hodgkin lymphoma

Two new targeted treatments slow progression of chronic-lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma.

Proportion of different genetic mutations quantified in individual colorectal cancers

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Researchers have quantified the mutational profiles for cell clusters in individual colorectal cancer tumors that have metastasized.

Novel melanoma treatment strategy offers promise

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A new strategy targeting a protein that drives melanoma growth has been proposed in a research report.

BRCA-targeting drug has benefit in prostate cancer

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Trials results indicate that the pioneering drug olaparib, which targets inherited mutations, can be beneficial for men with prostate cancer.

Proton radiotherapy delivers more accurate cancer treatment with less collateral damage

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Accurate administration of proton radiotherapy in mobile organs, such as the lung, can be difficult, but researchers have developed a model that will allow for better beam targeting.

Macrophages may play critical role in melanoma resistance to BRAF inhibitors

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Investigators have discovered one way in which melanoma becomes resistant to a particular form of targeted therapy, a discovery that may lead to a new melanoma target or prompt new designs for treatment.

Triple combination of two targeted therapies + immunotherapy is more effective in advanced melanoma

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A new triple combination therapy has shown signs that it can more effectively control advanced melanoma that previous, dual-therapy combinations.

Targeted drug doubles progression-free survival in Hodgkin lymphoma

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A phase 3 trial of brentuximab vedotin (BV) showed that adults with hard-to-treat Hodgkin lymphoma given BV after stem cell transplantation survived without the disease progression for twice as long as when a placebo was administered.

Online education tool helps bridge gaps in therapeutic decision-making for NSCLC

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A new online tool uses a patient's molecular characteristics and provides feedback from an expert panel to help oncologists with therapeutic decision-making for advanced non-small cell lung cancer (NSCLC).

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

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Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

New therapeutic strategy discovered for ovarian cancer

New therapeutic strategy discovered for ovarian cancer

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Researchers have identified a new therapeutic target for a particularly aggressive form of ovarian cancer, opening the door to effective targeted therapy development.

Potential treatment for pancreatic cancer could increase life expectancy

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Researchers have developed a device that uses electric fields to drive chemotherapy drugs through the protective barrier of tissue and directly into pancreatic tumors, preventing their growth.

Lung cancer may be treatable with use of SapC-DOPS technology

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The therapeutic agent SapC-DOPS may have use in lung cancer treatment, according to a new study .

Study points to potential new drug target for lung cancer

Study points to potential new drug target for lung cancer

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A recent study suggests that targeting a key enzyme and its associated metabolic programming could lead to a novel drug development for lung cancer treatment.

Targeting survival protein may counter drug-resistance in non-Hodgkin lymphomas

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Targeting a specific cell survival protein could be key to treating some lymphomas, including those with genetic defects that make them resistant to standard therapies.

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

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Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Targeting microRNA may benefit some patients with ovarian and breast cancer

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Researchers believe they may have found a molecule-based approach to halting the destructive quality of the 3q26.2 amplicon, a frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.

Oral inhibitor shows clinical activity in poor-prognosis acute myelogenous leukemia (AML)

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An oral targeted agent has shown encouraging activity and limited side effects in patients with treatment-resistant or relapsed acute myelogenous leukemia (AML), according to research.

New kind of targeted drug is promising for patients with leukemia

New kind of targeted drug is promising for patients with leukemia

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Patients with advanced leukemia, when treated with a new type of cancer therapy that blocks mutated IDH2 protein, showed dramatic results in a clinical trial.

Vaccine targeting breast cancers produced robust immune response

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A DNA vaccine targeting the breast cancer-associated antigen mammaglobin-A was proven safe and found to effectively elicit immune responses in women with metastatic breast cancer, according to a new study.

Evolutionary principles used to model cancer mutations and discover potential therapeutic targets

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Researchers are now examining specific genetic mutations from a more Darwinian standpoint, to aid cancer treatment.

Evolving roles for oncology nurses: Biospecimen collection

Evolving roles for oncology nurses: Biospecimen collection

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Personalized medicine is changing oncology nursing. This primer explains best practices for collecting and preparing biospecimens used to guide therapy.

The Promise of Precision Cancer Treatment (Infographic)

The Promise of Precision Cancer Treatment (Infographic)

Precision cancer treatment examines tumors on a genetic level with an aim to uncover the cause of the cancer's growth.

Targeting a unique receptor promising for glioblastoma multiforme

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Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.

Improved response rate and survival with dabrafenib plus trametinib versus vemurafenib alone

Targeting BRAF V600E/K mutation-positive melanoma with dabrafenib in combination with trametinib achieves longer overall survival and impoved response rates, compared to treatment with vemurafenib alone.

Crizotinib treatment effective against ROS1-positive lung cancer

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Treatment with the drug crizotinib has been effective for stopping lung tumor growth driven by rearrangements of the ROS1 gene.

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