A DNA vaccine targeting the breast cancer-associated antigen mammaglobin-A was proven safe and found to effectively elicit immune responses in women with metastatic breast cancer, according to a new study.
Researchers are now examining specific genetic mutations from a more Darwinian standpoint, to aid cancer treatment.
Personalized medicine is changing oncology nursing. This primer explains best practices for collecting and preparing biospecimens used to guide therapy.
Precision cancer treatment examines tumors on a genetic level with an aim to uncover the cause of the cancer's growth.
Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.
Targeting BRAF V600E/K mutation-positive melanoma with dabrafenib in combination with trametinib achieves longer overall survival and impoved response rates, compared to treatment with vemurafenib alone.
Treatment with the drug crizotinib has been effective for stopping lung tumor growth driven by rearrangements of the ROS1 gene.
An analysis of circulating tumor cells (CTCs) in a pancreatic cancer model identified several different classes of CTCs and found unexpected factors that may prove to be future targets for improved treatment.
A targeted combination drug therapy has shown efficacy for metastatic melanoma, showing reduction in both mortality and disease progression.
About 14.5 million U.S. cancer survivors are alive today, but aging population and increasing obesity threaten progress.
Integrated approach to pinpoint genetic drivers of cancer uncovers viable targets for breast cancer therapySeptember 11, 2014
Researchers have developed a new integrated approach to identify the genetic drivers of cancer, uncovering eight genes necessary for cell proliferation in breast cancer.
EGFR mutations in circulating tumor DNA (ctDNA) can be used in place of tumor tissue in non-small cell lung cancer (NSCLC) diagnosticsSeptember 10, 2014
Epidermal growth factor receptor mutations found in ctDNA in the plasma of patients with advanced non-small cell lung cancer correlates well with the EGFR mutations from patient-matched tumor tissue DNA.
Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.
New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.
Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.
In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers report that they have identified a possible new drug target for treating the disease.
A new molecular analysis tool accurately detected the level of an important target for immunotherapy in early stage breast cancers.
Researchers have developed a new way to identify possible therapeutic targets for patients with drug resistant melanoma.
Research has shown that a mutated form of T. gondii may help galvanize the human immune system to fight cancer.
The protein galectin-1 has been identified as a possible therapeutic target for pancreatic cancer; new research has demonstrated that inhibiting this protein in mice with pancreatic cancer increased survival by 20%.
A research team has created a new, self-assembling nanoparticle that can increase the effectiveness of magnetic resonance imaging (MRI) cancer detection.
Changes in how follicular lymphoma is managed have led to substantial improvement in prognosis and over all survival for patients with the disease.
Scientists have shown that DNA origami can be used for the targeted delivery of cancer drugs to tumor cells in mice.
Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.
An international team of scientists have discovered a faulty process in certain bladder cancers that could point to new ways to treat patients with an aggressive form of the disease.
Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment.
Researchers have found that as antihistamines do their job, they also interfere with the function of myeloid-derived suppressor cells—a type of cell known to hinder the body's ability to combat tumors.
Cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy, opposing the current requirement for continuous treatment, according to a new study.
Up to 40% of patients with lung cancer do not respond to a targeted therapy designed to block tumor growth. Now, scientists have discovered why that intrinsic resistance occurs.
New findings from a large phase I study of patients with advanced melanoma show that the PD-1 targeting antibody MK-3475 yields long-term responses in a high percentage of patients.
- Key discovery in understanding successes and failures of immunotherapy
- Added sugars may increase blood pressure more than high salt consumption
- Researchers identify biological indicator of response to new ovarian cancer drug
- Managing obesity should be part of cancer care
- Galeterone active in one form of castration-resistant prostate cancer
- Importance of sequence in administering premeds with paclitaxel
- Tamoxifen found to lower breast cancer rates among high-risk women in trial
- SABCS: Male breast cancer prognosis falls behind that for women
- Pembrolizumab safe, and even effective in some patients, for triple-negative breast cancer
- Capecitabine does not improve survival in elderly patients with early stage breast cancer
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