Targeted Therapy

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

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The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

Gene Alterations May Explain Treatment Resistance of Triple-negative Breast Cancer

Gene Alterations May Explain Treatment Resistance of Triple-negative Breast Cancer

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Amplification of the JAK2 gene frequently occurs in triple-negative breast cancer (TNBC), suggesting that specific inhibitors of JAK2 should be investigated in TNBC.

New Mechanism to Target RAS Genes Identified

New Mechanism to Target RAS Genes Identified

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A small molecule that inhibits RAS protein interactions offers hope for targeting this elusive protein. It is one of the most sought-after cancer targets for drug developers, but the mutant RAS protein lacks drug-binding pockets.

Microneedle Patch Delivers Localized Immunotherapy for Melanoma

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Microneedles embedded in a patch deliver cancer immunotherapy treatment directly to the site of melanoma, according to preliminary findings in animal studies.

Presurgical Treatment in HER2-positive Breast Cancer Achieves Significant Reduction in Disease

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Treatment with lapatinib and trastuzumab before surgery and chemotherapy led to significant shrinkage or disappearance of the tumors in approximately 25% of women with HER2-positive breast cancer.

Cell Growth Inhibitor Overcomes Therapy Resistance and Delays Tumor Recurrence in Breast Cancer

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Cyclin D1/CDK4 inhibitor treatment overcame resistance to targeted therapy in transgenic mouse models, cell cultures, and human tissue samples of HER2-positive breast cancer.

Targeted Radiation Holds Promise for Early Breast Cancer

Targeted Radiation Holds Promise for Early Breast Cancer

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Limited radiotherapy effective after low-risk tumors are removed, but questions remain.

Interactions of Cancer-causing Gene May Lead to Therapeutic Target

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An exploration of the interaction between the protein produced by the common cancer-causing KRAS gene and the AGO2 protein may lead to the possibility of interrupting the KRAS-AGO2 interaction as a possible therapy.

HER2-associated Lung Cancer: Mutations and Amplifications Result in Different Cancers

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Two distinct causes of HER2 activation in lung cancer were demonstrated in a recent study. These findings imply that HER2-positive lung cancer may need different targeted therapies to combat these related but possibly distinct diseases.

Targeted Hormone-radiation Treatment Shows Promise in Midgut Neuroendocrine Tumors

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Tumor growth may be substantially slowed by the novel therapy 177Lutetium-DOTATATE (Lutathera), according to early results from a phase III study of patients with previously treated, advanced midgut neuroendocrine tumors.

CDK4/6 Inhibitors Exploit a Unique Vulnerability in Pancreatic Cancer

CDK4/6 Inhibitors Exploit a Unique Vulnerability in Pancreatic Cancer

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The metabolism of pancreatic cancer cells is altered by the anticancer activity of CDK4/6 inhibitors. Researchers hope this biologic vulnerability could be exploited to treat pancreatic cancer.

Genomic Analysis Reveals Potential Therapeutic Options for Breast Cancer

Genomic Analysis Reveals Potential Therapeutic Options for Breast Cancer

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Dozens of new uses for existing drugs, new targets for drug discovery, and new drug combinations have been suggested by the largest analysis of breast cancer cell function to date.

Using Mouse Avatars Aids Identification of Effective Targeted Therapies for Patients With Melanoma

Using Mouse Avatars Aids Identification of Effective Targeted Therapies for Patients With Melanoma

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Using xenograft mice as avatars of patients with melanoma, scientists demonstrated that a previously ineffective targeted drug may halt disease progression in certain patients.

Progression-free Survival in Advanced Renal Cell Carcinoma Is Improved With Cabozantinib

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Findings of the randomized, phase 3 METEOR trial demonstrate progression-free survival in patients with advanced renal cell carcinoma is improved with cabozantinib compared with everolimus.

Triple Therapy Shows Promise in Treatment Resistant Subtype of Lung Cancer

Triple Therapy Shows Promise in Treatment Resistant Subtype of Lung Cancer

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Lung cancers with KRAS-related gene mutations might benefit from a triple therapy regimen of 2 experimental drugs plus radiation therapy.

New Breast Cancer Drug Showing Potential as a Treatment for Other Types of Cancer

New Breast Cancer Drug Showing Potential as a Treatment for Other Types of Cancer

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Palbociclib, a new oral treatment for certain types of breast cancer, demonstrates potential as a treatment for other types of cancer as well.

Newly Identified Protein May Provide a Target for MYC Oncogene Activity in Several Cancers

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Researchers identified a protein that is essential for MYC to cause cancer in mouse models, and they believe, could be a target for anticancer therapy.

Mandatory Biopsy May Hinder Eligibility of Potential Participants in Cancer-related Clinical Trials

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Mandatory tumor tissue specimens and associated analyses for clinical trial participation appear to be a significant barrier to clinical trial enrollment and may delay treatment.

Drug Resistance Became Tumor Resensitization in a Unique Case of a Patient With Lung Cancer

Drug Resistance Became Tumor Resensitization in a Unique Case of a Patient With Lung Cancer

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The evolution of drug resistance in a patient with lung cancer was demonstrated in a recent case. In the case, molecular analysis of a metastatic lesion revealed resistance to a third targeted therapy; however, the new mutation restored tumor response to the first targeted therapy used.

Enzyme Demonstrates Effectiveness as a Targeted Therapy in Hard-to-treat Subtypes of Breast Cancer

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Findings from a recently published study point to the enzyme casein kinase 1δ (CK1δ), a critical regulator of growth, as a novel and highly vulnerable therapeutic target in hard-to-treat subtypes of breast cancer.

Current Targeted Therapies May Be Effective in Gastric Cancer

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Certain drugs currently used to treat breast, ovarian, and pancreatic cancers could also be used to treat certain gastric cancers with a particular genomic molecular fingerprint.

Newly Identified Gene Mutations May Expand Indications for Existing Targeted Cancer Treatments

Newly Identified Gene Mutations May Expand Indications for Existing Targeted Cancer Treatments

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Researchers identified two new cancer-causing gene mutations that could lead to more targeted and effective treatments for certain lung and prostate cancers.

Genome sequencing database provides easy access to information on clinically important cancer gene mutations

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Researchers designed an online database, the Cancer Driver Log (CanDL) to help oncologists and other health care professionals identify key mutations that drive tumor growth in tissues.

MRI scanners can steer tumor-busting viruses to specific target sites within the body

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Scientists have discovered that magnetic resonance imaging (MRI) scanners, normally used to produce images, can be used direct tumor therapies to specific target sites.

Landmark basket study is changing how drug trials are conducted

Landmark basket study is changing how drug trials are conducted

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Results are in from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients' tumors rather than where their cancer originated.

Genetic test helps identify risk for more aggressive disease, improving myeloma treatment

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New research has identified as few as nine genetic features would need to be tested to identify high-risk patients who might benefit from intensive myeloma treatment.

New tool uses drug spillover to match cancer patients with treatments

New tool uses drug spillover to match cancer patients with treatments

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A new tool predicts what genetics are truly driving the cancer in any population of cells and helps the user choose the best kinase inhibitor to address the issue.

Targeted therapy for skin cancer is effective in patients with sonic hedgehog (SHH) subtype of medulloblastoma

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A targeted therapy already used to treat advanced skin cancer has also been found to be effective when used to treat the most common subtype of adult medulloblastoma.

Dietary intervention primes triple-negative breast cancer cells for targeted therapy

Dietary intervention primes triple-negative breast cancer cells for targeted therapy

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A diet that starves triple-negative breast cancer cells of an essential nutrient primes the cancer cells to be more easily killed by targeted treatment.

Proton therapy for esophageal cancer has fewer side effects than older radiation therapies

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New research indicates that treating patients with esophageal cancer with proton therapy produces fewer toxic side effects than utilizing older radiation therapies.

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