Targeted Therapy

Macrophages may play critical role in melanoma resistance to BRAF inhibitors

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Investigators have discovered one way in which melanoma becomes resistant to a particular form of targeted therapy, a discovery that may lead to a new melanoma target or prompt new designs for treatment.

Triple combination of two targeted therapies + immunotherapy is more effective in advanced melanoma

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A new triple combination therapy has shown signs that it can more effectively control advanced melanoma that previous, dual-therapy combinations.

Targeted drug doubles progression-free survival in Hodgkin lymphoma

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A phase 3 trial of brentuximab vedotin (BV) showed that adults with hard-to-treat Hodgkin lymphoma given BV after stem cell transplantation survived without the disease progression for twice as long as when a placebo was administered.

Online education tool helps bridge gaps in therapeutic decision-making for NSCLC

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A new online tool uses a patient's molecular characteristics and provides feedback from an expert panel to help oncologists with therapeutic decision-making for advanced non-small cell lung cancer (NSCLC).

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

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Working with cells taken from children with a rare form of brain cancer, scientists have identified a genetic pathway that may spur cancer cell growth and resistance to anticancer treatment.

New therapeutic strategy discovered for ovarian cancer

New therapeutic strategy discovered for ovarian cancer

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Researchers have identified a new therapeutic target for a particularly aggressive form of ovarian cancer, opening the door to effective targeted therapy development.

Potential treatment for pancreatic cancer could increase life expectancy

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Researchers have developed a device that uses electric fields to drive chemotherapy drugs through the protective barrier of tissue and directly into pancreatic tumors, preventing their growth.

Lung cancer may be treatable with use of SapC-DOPS technology

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The therapeutic agent SapC-DOPS may have use in lung cancer treatment, according to a new study .

Study points to potential new drug target for lung cancer

Study points to potential new drug target for lung cancer

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A recent study suggests that targeting a key enzyme and its associated metabolic programming could lead to a novel drug development for lung cancer treatment.

Combination therapy can reduce chance of recurrence from small HER2+ breast tumors

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Women with stage 1 HER2-positive breast tumors who received a combination of lower-intensity chemotherapy and a targeted drug following surgery were unlikely to suffer cancer recurrence within 3 years of treatment.

Targeting microRNA may benefit some patients with ovarian and breast cancer

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Researchers believe they may have found a molecule-based approach to halting the destructive quality of the 3q26.2 amplicon, a frequent chromosomal aberrations seen in many cancers, including ovarian and breast cancers.

Oral inhibitor shows clinical activity in poor-prognosis acute myelogenous leukemia (AML)

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An oral targeted agent has shown encouraging activity and limited side effects in patients with treatment-resistant or relapsed acute myelogenous leukemia (AML), according to research.

New kind of targeted drug is promising for patients with leukemia

New kind of targeted drug is promising for patients with leukemia

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Patients with advanced leukemia, when treated with a new type of cancer therapy that blocks mutated IDH2 protein, showed dramatic results in a clinical trial.

Vaccine targeting breast cancers produced robust immune response

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A DNA vaccine targeting the breast cancer-associated antigen mammaglobin-A was proven safe and found to effectively elicit immune responses in women with metastatic breast cancer, according to a new study.

Evolutionary principles used to model cancer mutations and discover potential therapeutic targets

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Researchers are now examining specific genetic mutations from a more Darwinian standpoint, to aid cancer treatment.

Evolving roles for oncology nurses: Biospecimen collection

Evolving roles for oncology nurses: Biospecimen collection

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Personalized medicine is changing oncology nursing. This primer explains best practices for collecting and preparing biospecimens used to guide therapy.

The Promise of Precision Cancer Treatment (Infographic)

The Promise of Precision Cancer Treatment (Infographic)

Precision cancer treatment examines tumors on a genetic level with an aim to uncover the cause of the cancer's growth.

Targeting a unique receptor promising for glioblastoma multiforme

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Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, but new therapeutic strategies are being investigated.

Improved response rate and survival with dabrafenib plus trametinib versus vemurafenib alone

Targeting BRAF V600E/K mutation-positive melanoma with dabrafenib in combination with trametinib achieves longer overall survival and impoved response rates, compared to treatment with vemurafenib alone.

Crizotinib treatment effective against ROS1-positive lung cancer

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Treatment with the drug crizotinib has been effective for stopping lung tumor growth driven by rearrangements of the ROS1 gene.

Gene expression patterns revealed in pancreatic circulation tumor cells

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An analysis of circulating tumor cells (CTCs) in a pancreatic cancer model identified several different classes of CTCs and found unexpected factors that may prove to be future targets for improved treatment.

Targeted combination therapy halts disease and extends life in advanced melanoma

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A targeted combination drug therapy has shown efficacy for metastatic melanoma, showing reduction in both mortality and disease progression.

AACR: Targeted drugs and prevention reduce cancer mortality

AACR: Targeted drugs and prevention reduce cancer mortality

About 14.5 million U.S. cancer survivors are alive today, but aging population and increasing obesity threaten progress.

Integrated approach to pinpoint genetic drivers of cancer uncovers viable targets for breast cancer therapy

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Researchers have developed a new integrated approach to identify the genetic drivers of cancer, uncovering eight genes necessary for cell proliferation in breast cancer.

EGFR mutations in circulating tumor DNA (ctDNA) can be used in place of tumor tissue in non-small cell lung cancer (NSCLC) diagnostics

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Epidermal growth factor receptor mutations found in ctDNA in the plasma of patients with advanced non-small cell lung cancer correlates well with the EGFR mutations from patient-matched tumor tissue DNA.

Finding keys to drug therapy resistance in glioblastoma

Finding keys to drug therapy resistance in glioblastoma

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Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumor's epigenetic signature.

Repurposing antidepressant may target new medulloblastoma pathway

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New research suggests that an antidepressant medication, repurposed, could target a novel molecular pathway that causes an aggressive form of medulloblastoma.

Gene likely to promote childhood cancers pinpointed

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Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.

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