Targeted Therapy

Protein inhibition opens door for pancreatic cancer treatment

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The protein galectin-1 has been identified as a possible therapeutic target for pancreatic cancer; new research has demonstrated that inhibiting this protein in mice with pancreatic cancer increased survival by 20%.

New nanoparticle could improve MRI scanning for cancer diagnosis

New nanoparticle could improve MRI scanning for cancer diagnosis

A research team has created a new, self-assembling nanoparticle that can increase the effectiveness of magnetic resonance imaging (MRI) cancer detection.

Managing follicular lymphoma

Managing follicular lymphoma

Changes in how follicular lymphoma is managed have led to substantial improvement in prognosis and over all survival for patients with the disease.

DNA origami can deliver targeted cancer drugs

DNA origami can deliver targeted cancer drugs

Scientists have shown that DNA origami can be used for the targeted delivery of cancer drugs to tumor cells in mice.

New mutations found in common lung cancer subtype

New mutations found in common lung cancer subtype

Researchers from The Cancer Genome Atlas Research Network have identified novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer.

A new target for aggressive bladder cancer found

A new target for aggressive bladder cancer found

An international team of scientists have discovered a faulty process in certain bladder cancers that could point to new ways to treat patients with an aggressive form of the disease.

Way to diagnose aggressiveness of oral cancer found

Way to diagnose aggressiveness of oral cancer found

Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment.

Can antihistamines be used to fight cancer?

Can antihistamines be used to fight cancer?

Researchers have found that as antihistamines do their job, they also interfere with the function of myeloid-derived suppressor cells—a type of cell known to hinder the body's ability to combat tumors.

Game changer for leukemia therapy

Game changer for leukemia therapy

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Cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy, opposing the current requirement for continuous treatment, according to a new study.

Resistance to targeted therapy for lung cancer can be reversed

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Up to 40% of patients with lung cancer do not respond to a targeted therapy designed to block tumor growth. Now, scientists have discovered why that intrinsic resistance occurs.

Immunotherapy targeting PD-1 active against metastatic melanoma

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New findings from a large phase I study of patients with advanced melanoma show that the PD-1 targeting antibody MK-3475 yields long-term responses in a high percentage of patients.

Investigators learn how gene mutations cause melanoma of the eye

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Researchers have identified a therapeutic target for treating the most common form of eye cancer in adults.

ASCO: HPV-targeted T-cell therapy may combat advanced cervical cancer

ASCO: HPV-targeted T-cell therapy may combat advanced cervical cancer

A new type of therapy, human papillomavirus (HPV)-targeted adoptive T-cell therapy, shows promise in treating some women with advanced cervical cancer, but side effects were often severe.

Scientists at Scripps Florida find new targets that could increase effectiveness and reduce side effects in breast cancer treatments

Scientists at Scripps Florida find new targets that could increase effectiveness and reduce side effects in breast cancer treatments

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer.

Immune therapy offers hope for multiple myeloma

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Genetically modifying immune cells might effectively treat multiple myeloma, according to a new study.

Novel target identified for chemotherapy-resistant leukemia cells

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By targeting a particular receptor, chemotherapy-resistant cancer cells can be killed in an acute form of childhood leukemia, according to new research.

New approach may overcome breast cancer resistance to HER2-targeted therapies

New approach may overcome breast cancer resistance to HER2-targeted therapies

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Resistance to a combination of HER2-targeted therapies, trastuzumab and lapatinib, was associated with elevated activation of a group of proteins called fibroblast growth factor receptors, which are the target of a number of drugs under development.

Investigational drug benefits subgroup of patients with head and neck cancer

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Patients with recurrent or metastatic squamous cell carcinoma of the head and neck may benefit from treatment with the investigational drug dacomitinib.

New drug shows promise in early studies for metastatic breast cancer

New drug shows promise in early studies for metastatic breast cancer

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The new oral drug LY2835219, an inhibitor of cyclin-dependent kinases 4 and 6, showed early promise as monotherapy for patients with metastatic breast cancer.

Differentiation therapy holds promise as a targeted therapy for pediatric neuroblastoma

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The important role of microRNAs in regulating neuroblastoma development has been unveiled by new research.

Targeted drug may prolong survival for patients with cervical cancer

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A new clinical study has found that erlotinib has promising potential to improve treatment for cervical cancer.

Novel biologic drug holds promise for individualized ovarian cancer treatment

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Researchers have developed a biologic drug that would prevent the production of a protein known to allow ovarian cancer cells to grow aggressively while being resistant to chemotherapy.

Fast and effective mechanism combats ovarian tumors

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A new type of strategy has been proposed to tackle an aggressive subtype of ovarian cancer by using a nanoscale drug-delivery system designed to target specific cancer cells.

New target found for triple-negative breast cancer

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A new study shows that targeting a particular nuclear protein may provide an effective approach for treating triple-negative breast cancer.

Potential options to attack stem cells in triple-negative breast cancer

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A protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells, according to new research.

TCGA study of bladder cancer reveals potential drug targets

TCGA study of bladder cancer reveals potential drug targets

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Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer.

New hormone receptor targets for breast cancer discovered

New hormone receptor targets for breast cancer discovered

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Androgen and vitamin D receptors can be targeted in breast cancer, according to new research.

Targeted therapy succeeds for common form of lung cancer in initial testing

Targeted therapy succeeds for common form of lung cancer in initial testing

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The most common genetic subtype of lung cancer, which has long defied treatment with targeted therapies, has had its growth halted by a combination of two drugs already in use in laboratory and animal studies.

Complete recovery from hairy cell leukemia after vemurafenib treatment

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Vemurafenib, a BRAF inhibitor that has been approved as a treatment for advanced melanomas, has also proved successful in treating hairy cell leukemia.

Cellular senescence leads to acute promyelocytic leukemia cure

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Targeted treatments for acute promyelocytic leukemia cause a cascade of molecular events that lead to cellular senescence and recovery. This action model could be activated in other types of cancers.

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