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TAPAZOLE
Thyroid disease
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Drug Name:

TAPAZOLE Rx

Generic Name and Formulations:
Methimazole 5mg, 10mg; scored tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for TAPAZOLE:

Hyperthyroidism.

Adult:

Initially 15–60mg daily in 3 divided doses, depending on severity of disease. Maintenance: 5–15mg daily.

Children:

Initially 0.4mg/kg daily in 3 divided doses. Maintenance: ½ initial dose.

Contraindications:

Nursing mothers.

Warnings/Precautions:

Discontinue if agranulocytosis, aplastic anemia, exfoliate dermatitis, hepatitis, or elevated liver transaminases (3xULN) occurs. Monitor prothrombin time, WBC, bone marrow function. Pregnancy (Cat.D).

Interactions:

Potentiates anticoagulants.

Pharmacological Class:

Antithyroid.

Adverse Reactions:

Rash, GI disturbances, arthralgia, paresthesia, hair and taste loss, agranulocytosis, blood dyscrasias, aplastic anemia, hepatic dysfunction, drug fever, lupus-like syndrome, insulin autoimmune syndrome, periarteritis; nephritis (rare).

How Supplied:

Tabs—100

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