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SYNERCID
Bacterial infections
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Drug Name:

SYNERCID Rx

Generic Name and Formulations:
Quinupristin/dalfopristin 500mg per vial (as 150mg quinupristin and 350mg dalfopristin); pwd for IV infusion after reconstitution; preservative-free.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for SYNERCID:

Treatment of complicated skin and skin structure infections due to S. aureus (methicillin-susceptible) or S. pyogenes.

Adult:

Give by IV infusion over 60mins. ≥16yrs: 7.5mg/kg every 12hrs for at least 7 days.

Children:

<16yrs: not established; doses of 7.5 mg/kg every 8hrs or 12hrs have been used in a limited number of children under emergency-use conditions (see full labeling).

Warnings/Precautions:

Hepatic insufficiency. Pregnancy. Nursing mothers.

Interactions:

Avoid concomitant drugs known to prolong the QT interval. Potentiates CYP3A4 substrates (eg, midazolam, nifedipine, cisapride, carbamazepine, vinca alkaloids, taxanes, steroids, NNRTIs, protease inhibitors, statins); monitor esp. those with narrow therapeutic window (eg, cyclosporine, tacrolimus). May affect digoxin.

Pharmacological Class:

Streptogramin.

Adverse Reactions:

Inj site reactions, arthralgia, myalgia, GI upset, thrombophlebitis, rash, headache, pruritus; C. difficile-associated diarrhea.

How Supplied:

Single-dose vials—10

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