ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

SYNAREL
Endometriosis
Pituitary disorders
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

SYNAREL Rx

Generic Name and Formulations:
Nafarelin (as acetate) 200mcg/spray; intranasal soln.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for SYNAREL:

Endometriosis.

Adult:

≥18yrs: Start between days 2 and 4 of menstrual cycle. 400mcg daily as 1 spray in one nostril in AM and repeat in other nostril in PM. If menstruation continues after 2 months of therapy, increase to 800mcg daily as 1 spray each nostril AM and PM. Max therapy 6 months.

Children:

<18yrs: not established.

Contraindications:

Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers.

Warnings/Precautions:

Exclude pregnancy before treatment; use nonhormonal contraception during therapy; discontinue immediately if pregnancy occurs. Patients should adhere to regimen carefully. Missing successive doses may lead to breakthrough bleeding or ovulation. Risk factors for decreased bone mineral density (eg, chronic alcohol or tobacco abuse, family history of osteoporosis, chronic corticosteroids or anticonvulsants). Avoid sneezing during or immediately after dosing.

Interactions:

Avoid nasal decongestants until at least 2 hrs after dosing. Possible convulsions if concomitant with bupropion or SSRIs.

Pharmacological Class:

GnRH analogue.

Adverse Reactions:

Hypoestrogenic: hot flashes, decreased libido, vaginal dryness, headache, emotional lability, insomnia, bone density loss. Androgenic: acne, myalgia, breast size reduction, edema, seborrhea, weight gain, hirsutism, increased libido. Ovarian cysts. Nasal irritation.

How Supplied:

Nasal spray—8mL (60 sprays)

Indications for SYNAREL:

Central precocious puberty.

Adult:

Not applicable.

Children:

1600mcg daily as 2 sprays into each nostril in the AM and PM (total: 8 sprays/day); may increase to 1800mcg daily as 3 sprays into alternating nostrils 3 times daily (total: 9 sprays/day). Allow 30 seconds to elapse between sprays. Discontinue when resumption of puberty is desired.

Contraindications:

Undiagnosed abnormal vaginal bleeding. Pregnancy (Cat.X). Nursing mothers.

Warnings/Precautions:

Exclude pregnancy before treatment. Confirm diagnosis. Monitor hormonal effects within first 6–8 weeks, growth velocity and bone age velocity within first 3–6 months. Monitor for psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Avoid sneezing during or immediately after dosing.

Interactions:

Avoid nasal decongestants until at least 2 hrs after dosing. Possible convulsions if concomitant with bupropion or SSRIs.

Pharmacological Class:

GnRH analogue.

Adverse Reactions:

Acne, transient breast enlargement, vaginal bleeding or discharge, emotional lability, transient increase in pubic hair, body odor, seborrhea, hot flashes, rhinitis; occasional pituitary gland morphological changes.

How Supplied:

Nasal spray—8mL (60 sprays)

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs