Adult survivors of childhood cancer are at increased risk for late adverse pulmonary events.
Cancer survivors who are nonwhite, less educated, older, and/or have comorbidities were less likely to receive adequate cancer pain management.
Quality of Life and Cosmetic Result of Single-port Access Endoscopic Thyroidectomy via Axillary Approach in Patients with papillary thyroid carcinoma
[OncoTargets and Therapy] This research reviews the effects of single-port access transaxillary totally endoscopic thyroidectomy on outcomes following surgery, including quality of life and cosmetic result, in patients with papillary thyroid carcinoma (PTC).
Older cancer survivors' self-reports of sexual activity and functioning are comparable to age-matched people without cancer; despite this, sexual dissatisfaction is more prevalent among cancer survivors than age-matched cancer-free persons.
Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma
The addition of elotuzumab to bortezomib/dexamethasone appears to increase progression-free survival in relapsed/refractory multiple myeloma (RRMM).
Younger cancer survivors in Norway were more likely to be financially dependent and unemployed than individuals without cancer.
Patients with metastatic non-small cell lung cancer demonstrated prolonged median progression-free survival with the administration of erlotinib below the maximum tolerated dose.
Research indicates that metformin can confer improved survival for patients with colorectal cancer that also have diabetes.
Treatment with daratumumab, lenalidomide, and dexamethasone (DRd) may be superior to lenalidomide and dexamethasone (Rd) alone in patients with relapsed or refractory multiple myeloma.
Dasatinib and nilotinib are associated with similar response rates and survival outcomes in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP).
Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.
Use of androgen suppression therapy may negatively impact survival in African American patients with favorable-risk prostate cancer.
Survival among women age 40 years and younger with breast cancer appears to vary according to breast cancer subtype, with age particularly prognostic for women with luminal type breast cancers.
A recent study examined the possible correlation between Medicaid coverage status and overall survival for patients with head and neck cancer.
As salvage radiotherapy (SRT) outcomes may be affected by factors associated with prostatectomy findings, they may be positively affected when used at lower prostate-specific antigen (PSA) levels.
Acupressure reduced persistent fatigue in women who had been treated for breast cancer, improving both sleep and quality of life.
Choosing no treatment and regular check-ups didn't seem to stress men with low-risk disease
Low aerobic capacity has greater effect on longevity than even high cholesterol, or high blood pressure.
Tyrosine Kinase Inhibitor Therapy Can Be Safely Stopped in Select Patients With CML in Chronic Phase
A high percentage of patients with CML treated with TKIs achieve deep molecular responses and can safely stop therapy. Initials results of the EURO-SKI trial define prognostic markers that indicate durability of deep molecular responses after stopping TKI therapy.
Systematic Palliative Care Provides Greater Improvement in Quality of Life for Patients with Pancreatic Cancer
Quality of life is significantly improved for patients with pancreatic cancer when systematic palliative care is administered vs on-demand palliative care.
A very large retrospective study of patients with stage II colon cancer found adjuvant therapy improves survival, regardless of treatment regimen, patient age, or high-risk pathologic risk features.
Although most adolescent survivors of childhood cancer have no reported psychological symptoms, those who do often have multiple symptoms and distinct symptom profiles.
Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.
Improved cancer detection and advances in treatment mean larger numbers of older cancer patients are becoming survivors, combined with demographic trends. But older patients are underrepresented in clinical trials.
In addition to improving overall survival compared with dacarbazine in patients with advanced melanoma, nivolumab maintains baseline levels of health-related quality of life to ultimately confer long-term quality of survival benefit.
In a large cohort of hematologic oncologists surveyed in the United States, standard end-of-life quality measures were highly acceptable, but unrealistic patient expectations are the greatest impediment to quality end-of-life care.
Memory problems in breast cancer survivors appear associated with the high stress load these patients experience rather than their treatment, and moderate-to-vigorous physical activity may help subjective memory in these patients.
Lung cancers that manifest as nonsolid nodules seem to have indolent course, according to recent research data.
Relaxing acupressure resulted in significant improvement in persistent fatigue, sleep quality, and quality of life among survivors of breast cancer, a recent study has shown.
The Patient-Owned Survivorship Transition Care for Activated, Empowered survivors (POSTCARE) intervention resulted in clinically meaningful improvements in 3 domains of quality of life (QoL) among survivors of breast cancers.
A group of researchers sought to examine the physical functioning of patients with breast cancer, in various age brackets, who were enrolled in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) phase III trial.
Likelihood of other chronic conditions will stress health care system in next two decades, as more patients with cancer live longer.
Nearly 1 in 12 patients with a cancer from the 10 most common cancer sites developed a second primary neoplasm during survivorship.
Many Older Women With Early Stage Breast Cancer Are Susceptible to Functional Decline After Starting Treatment
Approximately 20% of older women with stage I-III breast cancer lost the ability to complete some basic tasks of independent living within 1 year of starting treatment. However, an assessment tool can identify those women at greatest risk of posttreatment functional decline.
Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.
Recent results from a multicenter, phase 2 trial suggest that patients with HIV and aggressive lymphoma should receive autologous stem cell transplant as standard of care. Risk of serious complications after transplant in these patients is equal to that of patients without HIV.
Undergoing pleurectomy and decortication for malignant pleural mesothelioma generally leads to improved quality of life after the surgery.
Cancer and dementia patients get more access to palliative care than do patients with many other chronic conditions, recent research indicates.
Ibrutinib treatment for chronic lymphocytic leukemia with the deletion of chromosome 17p (del17p CLL) increases the percentage of patients alive at 30 months over other therapies for del17p CLL.
In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.
Event-free survival for adult patients with ALL has improved from 40% to 73% with the implementation of the NOPHO ALL 2008 protocol in July 2008.
Adjuvant chemotherapy in patients with stage Ib non-small cell lung cancer improved overall survival and 5-year overall survival.
The number of patients older than 75 years who do not undergo surgery is increasing, especially among those with stage III or IV ovarian cancer. Approximately 50% do not undergo surgery and 25% receive no treatment at all.
New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases
Researchers demonstrate how breast cancer cells invade bone marrow, where they escape chemotherapy and hormonal therapies that would otherwise eliminate the cancer cells.
Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.
A post-hoc analysis of the Phase 3 ASPIRE study indicates that treatment combining carfilzomib with lenalidomide and dexamethasone extended survival time for patients with multiple myeloma.
Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer
Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.
A decreasing number of adolescents are smoking, but e-cigarette use and rates of distracted driving are on the rise for this group.
Researchers found tracking symptoms and alerting doctors to problems early led to longer survival for patients with lung cancer.
Physical exercise may have a direct effect on cancer that is as effective as drugs for treating patients with prostate cancer, even for those with advanced stages of the disease.
Three in four of young or middle-aged patients with terminal cancer receive aggressive therapies in their last months of life.
At 3 years, 40% of patients with advanced melanoma treated with pembrolizumab are alive regardless of whether they had been treated with ipilimumab or not, follow-up results from the KEYNOTE-001 study reported at the ASCO 2016 Annual Meeting.
The longest overall survival follow-up among randomized phase 3 trials evaluating BRAF and MEK inhibitors in patients with BRAF-mutant metastatic melanoma to date has shown the best 3-year outcome with dabrafenib plus trametinib to be in patients with normal LDH and fewer than 3 disease sites, according to a presentation at the ASCO 2016 Annual Meeting.
NETTER-1 trial results of the somatostatin analogue peptide, 177Lu-DOTA0-Tyr3-octreotate (177Lu-Dotatate), suggest a potential survival benefit in patients with advanced midgut neuroendocrine tumors (NETs), attendees at the ASCO 2016 Annual Meeting were told.
Greatest survival benefit observed for those taking the drug before their cancer diagnosis.
Tailored dose-dense chemotherapy significantly improved event-free survival and also showed efficacy in relapse-free and overall survival compared with standard adjuvant chemotherapy in patients with high-risk breast cancer, according to results of the phase 3 PANTHER study reported at the 2016 ASCO Annual Meeting.
Lenalidomide maintenance after high-dose melphalan and autologous stem cell transplant (ASCT) significantly prolonged overall survival in patients with multiple myeloma compared with no maintenance, a meta-analysis of 3 randomized controlled trials presented at the 2016 ASCO Annual Meeting has found.
The introduction of palliative care shortly after a patient is diagnosed with cancer is associated with improved quality of life.
Patients whose treatment was based on the molecular characteristics of their particular tumor had significantly better outcomes compared with patients who did not.
Four in 10 patients with newly diagnosed and previously treated advanced melanoma were alive 3 years after initiating pembrolizumab.
Radiation therapy delivered to the critical vessels surrounding the prostate can result in erectile dysfunction and bladder and renal irritation. Vessel-sparing radiation and an improved understanding of the anatomy of the prostate can reduce these effects.
Including Quality Measures In Treatment Regimens Increases Survival in Stage IIIA Non-Small Cell Lung Cancer
When more quality measures are incorporated into patient care, survival rates for patients with stage IIIA non-small cell lung cancer (NSCLC) increase, but only 13% of eligible patients actually receive all 4 recommended quality measures.
Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer
Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.
Results from this study showed that 5-year survival for older patients after surgery for lung cancer is favorable. Based on these results, surgeons might be better equipped to individualize care for this older population.
Radiotherapy in combination with anti-androgen hormone therapy halves the risk of death from prostate cancer 15 years after diagnosis compared with hormone therapy alone.
A recent study examined depression and anxiety among family caregivers of patients with incurable cancer and sought to identify factors linked to these symptoms.
Chronic conditions commonly affect long-term quality of life for survivors of childhood cancer who are in their young adult years.
The immunotherapy drug nivolumab conferred a survival benefit in patients with head and neck cancer over standard chemotherapy.
The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.
Swallowing the liquid nicotine appears to affect children under 6 the most, and calls to poison control centers about accidental ingestion have sharply increased.
Video-assisted thoracoscopic surgery (VATS) is associated with less postoperative pain and better quality of life than anterolateral thoracotomy for the first year of surgery in patients with stage I NSCLC.
Delayed radiation therapy (RT) after surgery significantly increased the risk of recurrent disease in women treated for very early breast cancer.
A low-dose of aspirin could increase survival by up to 20% and help stop metastasis for patients receiving cancer treatment.
Progression-free-survival was improved in all prespecified patient groups, including those with high-risk cytogenetic abnormalities.
E-cigarettes have a strong potential to improve population health by reducing or displacing cigarette use. A team of international experts urged the US FDA to have a broad perspective when it comes to regulating e-cigarettes.
An AYA patient survivorship program jointly designed by a cancer institute and a community organization educates patients about their oncologic history and the effects of therapy, as well as provides resources to improve quality of life.
Socioeconomic status and features of physical health rather than tumor characteristics were associated with symptoms of depression among long-term survivors of colorectal cancer.
Longer survival was achieved with stereotactic radiosurgery (SRS) alone than with whole-brain radiation therapy (WBRT) in patients with fewer than 4 brain metastases from NSCLC or breast cancer.
The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.
Continuation of ceritinib therapy beyond disease progression was associated with prolonged survival, according to results from a retrospective study of the use of ceritinib to treat advanced ALK-positive NSCLC.
Smokers who visit a clinician for lung cancer screening should also be encouraged to quit smoking at that visit. Evidence-based behavioral strategies should be used, at each visit, to motivate smokers to quit.
Researchers found that men with prostate cancer who had exercised regularly had the best outcomes.
A study examined the relation between various forms of breast cancer therapies and risk of congestive heart failure.
Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.
Older women with diabetes and cancer taking metformin saw an increase in survival.
New technology has enabled doctors to administer higher doses of radiation to prostate cancer tumors with fewer side effects; however, escalating the dose of radiation may not help patients with localized prostate cancer in the long term.
Patients with classical Hodgkin lymphoma who are resistant to the CD30-directed antibody-drug conjugate brentuximab vedotin have poor outcomes.
Site of metastasis is key to the length of time a patient can survive metastatic castration-resistant prostate cancer (mCRPC).
Higher Treatment Volumes at Radiation Facilities Lead to Improved Overall Survival in Prostate Cancer
Among men with aggressive prostate cancer, overall survival (OS) rates improve when they receive radiation treatment at facilities that frequently perform the treatment.
Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia
Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.
Prolonged nightly fasting may reduce the risk of recurrence for patients with breast cancer.
The Samfund is a not-for-profit organization dedicated to easing the lasting financial effects of cancer treatments for young adults with the disease.
A complex surgical procedure to remove the prostate achieves excellent long-term survival for men with prostate cancer after radiation therapy has failed.
A weekly dose of temsirolimus 75 mg was found to be active in patients with relapsed/refractory primary CNS lymphoma (PCNSL); however, only some patients achieved long-term control.
Among women aged up to 49 years with a pregnancy-associated melanoma, recurrence rates were higher than seen in other groups.
Patients who have had cancer recently can still be treated with antibodies against tumor necrosis factor for inflammatory bowel disease.
Study Findings Show Possible Association Between PreLabor Cesarean Delivery and Risk for ALL in Young Children
The finding that prelabor cesarean delivery may have a correlation with acute lymphoblastic leukemia (ALL) may offer new targets for research into preventing cancer.
Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma
Female survivors of childhood Hodgkin lymphoma (HL) who received chest radiation can reduce their risk of breast cancer through early screening.
High neutrophil to lymphocyte ratio (NLR) is linked to worse prognosis in Caucasian patients with early breast cancer.
Reliance on PET to Detect Lung or Esophageal Cancer Recurrence May Lead to Overuse of the Imaging Modality
In posttreatment follow-up of lung and esophageal cancer, PET scans might be overused to detect cancer recurrence. Furthermore, PET scan use to detect recurrence does not increase survival.
- Breast Cancer Tumors Often a Composite of Tumor Types, Enhancing Treatment Resistance
- Massage Therapy Promising for Pain, Anxiety in Patients With Cancer
- Physical Activity May Reduce Mortality by 44% in Patients With Breast Cancer
- Early Tumor Size Change May Predict OS in Metastatic Breast Cancer
- Hormone Receptor Test Results in DCIS Core Needle Biopsy Not Used, Not Needed
- Exercise is as Effective in Treating Metastatic Prostate Cancer as Medication
- Walnut Consumption Changes Gut Microbiome, Decreases Growth of Colon Cancer in Mice
- Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows
- Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma
- Study Supports Increased Role for Surgery in Multimodality Therapy for Early Stage SCLC
- Favorable Perioperative Outcomes After Resection of Borderline Resectable Pancreatic Cancer Treated With Neoadjuvant Stereotactic Radiation and Chemotherapy Compared with Upfront Pancreatectomy for Resectable Cancer
- Adolescent Girls With Breast Cancer Family History Have Higher Self-esteem
- Gemcitabine Plus Cisplatin Prolongs PFS in Nasopharyngeal Cancer
- PMPS: A Common Late Effect of Surgery and Radiation for Breast Cancer
- TKIs Improve Overall Survival in NSCLC Patients With Leptomeningeal Metastases
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