Capecitabine does not improve survival in elderly patients with early stage breast cancer

In elderly patients with moderate- to high-risk early stage breast cancer for whom standard chemotherapy is too toxic, capecitabine did not improve outcomes when tested as monotherapy, according to recent data.

Key discovery in understanding successes and failures of immunotherapy

A key discovery has advanced the understanding of why some patients respond to ipilimumab, an immunotherapy drug, whereas others show less response.

Galeterone active in one form of castration-resistant prostate cancer

The anticancer drug galeterone has proved successful in lowering prostate-specific antigen levels in men with castration-resistant prostate cancer (CRPC).

Researchers identify biological indicator of response to new ovarian cancer drug

A method to determine which patients with ovarian cancer are more likely to respond well to the new anticancer drug rucaparib has been discovered.

Financial incentives double quit rates among smokers

Employing financial incentives to encourage smokers to reduce cigarette use can be a successful ploy.

Women with serious mental illness are less likely to receive cancer screenings

Women with symptoms of serious mental illness are significantly less likely to receive the three routine cancer screenings of Pap tests, mammography, and clinical breast examinations than women in the general population.

Adult survivors of childhood eye cancer experience few cognitive or social setbacks

Adult survivors of retinoblastoma, a type of eye cancer that usually develops in early childhood, are typically free from long-lasting effects, a new study shows.

Ovarian cancer patients may benefit from pelvic radiotherapy

Ovarian clear cell adenocarcinoma (CCA), a rare and aggressive form of ovarian cancer, may be treated by employing pelvic radiotherapy (RT).

Researchers suggest new follow-up model for breast cancer patients

The surveillance and follow-up of breast cancer survivors has the potential to improve, from the perspective of both patients and the health system.

Cognitive behavioral therapy for insomnia benefits cancer survivors

Cognitive behavioral therapy for insomnia benefits cancer survivors

Significant and durable improvements in insomnia and sleep quality, with and without armodafinil

Personalized genetic test predicts recurrence risk for prostate cancer

A genetic test has been developed to identify which men are at higher risk for prostate cancer recurrence after localized treatment with surgery or radiotherapy.

Tumor-analysis technology speeds treatment decisions for colorectal cancer

A novel medical-imaging technology, TexRAD, which analyzes the texture of tumors, has been shown in trials to enable early diagnosis of colorectal cancer in patients not responding to the standard cancer therapy better than other available tumor markers.

Conventional therapies are less effective in prostate cancer with BRCA mutations

Prostate cancer patients with hereditary mutations in the BRCA genes do not respond as well to conventional treatment such as surgery and radiotherapy, and they have a lower survival rate than patients who do not have these genetic mutations.

Chemotherapy after radiation slows progression of low-grade gliomas

A chemotherapy regimen of procarbazine, lomustine (CCNU), and vincristine (PCV) administered after radiation therapy improved both progression-free survival and overall survival in adults with low-grade gliomas.

Cancer-killing virus and doxorubicin act synergistically on metastatic ovarian cancer

Cancer-killing virus and doxorubicin act synergistically on metastatic ovarian cancer

A new approach to treatment using a cancer-killing virus combined with a chemotherapy drug may offer hope to those with advanced and recurrent forms of metastatic ovarian cancer.

Can consensus guidelines defining adequate margins decrease unnecessary breast cancer surgeries?

Nearly one quarter of all women who underwent initial breast conservation surgery (BCS) for breast cancer had a subsequent surgical intervention.

FOLFIRI treatment response not related to colorectal cancer classification by gene expression

The current classification system for colorectal cancer, based on genetic profiles, cannot be used to predict drug responses to FOLFIRI.

First targeted treatment to boost survival for esophageal cancer

Patients with a specific type of esophageal cancer survived longer when they were given the latest lung cancer drug, according to trial results.

Exercise therapy benefits breast cancer survivors

Exercise offers several benefits for breast cancer survivors, including reduced symptoms of lymphedema, according to a new study.

Navigation and survivorship: Rationalizing your program costs

Navigation and survivorship: Rationalizing your program costs

The cost of nonbillable nursing hours needed for these programs may hinder compliance. The right technology can link treatment silos and lower this cost.

Improved survival in pediatric umbilical cord transplants for hematologic cancers

Improved survival in pediatric umbilical cord transplants for hematologic cancers

A new standard of care for children facing acute myeloid leukemia (AML) may be clear, following a multiyear study.

Radiation exposure linked to aggressive thyroid cancers

For the first time, researchers have found that exposure to radioactive iodine is associated with more aggressive forms of thyroid cancer, according to a careful study of over a thousand individuals.

Monitoring psychosocial function in radiotherapy

Monitoring psychosocial function in radiotherapy

Psychosocial decline occurs in an estimated one-third of patients undergoing radiotherapy for cancer. These declines may sometimes be ameliorated by vigilant recognition of the need to refer patients for psychosocial support interventions.

Variation seen in number of cancer survivors undergoing HIV testing

Variation seen in number of cancer survivors undergoing HIV testing

Proportion undergoing testing varies by demographic and health-related factors, and by state, a study found.

Postoperative radiation therapy improves overall survival in resected NSCLC

Patients with non-small lung cancer (NSCLC) that received postoperative radiation therapy (PORT) lived an average of 4 months longer, when compared with patients who had the same disease progression and treatment criteria.

Stereotactic body radiotherapy (SBRT) effective for inoperable early stage lung cancer

Excellent long-term, local control for medically inoperable, early stage lung cancer patients is possible, according to a review of data from an institutional patient registry on stereotactic body radiotherapy (SBRT).

AHA: Even with weight gain, smoking cessation ups survival

AHA: Even with weight gain, smoking cessation ups survival

Research indicates smoking cessation boosts survival, even if there has been a weight gain.

Combination treatment for metastatic melanoma results in longer overall survival

Treatment with a combination of the drugs sargramostim plus ipilimumab, rather than ipilimumab alone, yielded longer overall survival and lower toxicity for patients with metastatic melanoma.

Cellular evidence for mind-body connection in breast cancer survivors

Researchers have demonstrated that employing mindfulness meditation or being a member of a support group has a positive physical impact at the cellular level in breast cancer survivors.

Risk prediction improved by new classification in chronic lymphocytic leukemia

Risk prediction improved by new classification in chronic lymphocytic leukemia

A new correlation discovered between specific molecular disease features and subgroups of patients with different prognoses could make identification of chronic lymphocytic leukemia (CLL) prognosis at the time of diagnosis possible.

Quality of biopsy directly linked to survival in patients with bladder cancer

Researchers have demonstrated for the first time that the quality level of diagnostic staging using biopsy in patients with bladder cancer is directly linked with their survival.

Resection for lung cancer in the elderly: Lobectomy better than sublobar resection

Resection for lung cancer in the elderly: Lobectomy better than sublobar resection

Significant advances have been made in screening for lung cancer and in targeting those patients who will benefit most from it. This study examines the impact of screening and treatment modalities on elderly patients.

Postsurgery readmission rates questioned as a quality measure in colorectal cancer care

Hospital readmission rates after colorectal cancer surgery showed little variation when the data was adjusted to account for patient characteristics, coexisting illnesses, and operation types.

ONA Interview: Breaking the barriers to effective palliative care

ONA Interview: Breaking the barriers to effective palliative care

Oncology Nurse Advisor talked with Diane Meier, MD, about the components of quality palliative care. Dr. Meier is director of the Center to Advance Palliative Care and vice-chair for Public Policy and a professor at Icahn School of Medicine at Mount Sinai in New York City; she is also the co-author of a new book on palliative care.

Breast cancer tumor response to neoadjuvant chemotherapy (NAC) measured

Diffuse optical spectroscopic tomographic imaging (DOST) may be useful in predicting which patients will best respond to chemotherapy used to reduce breast cancer tumors before surgery, according to a new study.

Early palliative care can cut hospital readmissions for cancer patients

A new, collaborative model in cancer care aims to reduce the rates at which patients go to intensive care or are readmitted to the hospital after discharge.

Chest radiation to treat childhood Wilms tumor increases breast cancer risk

A new study has found that patients who received chest radiation for Wilms tumor may be more susceptible to breast cancer later in life, due to their radiation exposure.

Trastuzumab shows benefit years after treatment for HER2+ breast cancer

The addition of trastuzumab to chemotherapy significantly improved the overall and disease-free survival of women with early stage HER2-positive breast cancer.

Innovative program helps combat catheter-associated urinary tract infections (CAUTI)

Innovative program helps combat catheter-associated urinary tract infections (CAUTI)

Oncology nurses at a New York cancer center successfully reduced the rate of CAUTIs at their facility to zero with a novel program that gives nurses autonomy in making care decisions for patients with urinary catheters.

Survival comparable after radiation therapy for tumors in left or right breast

Location of a breast cancer tumor, on the left or right side, does not impact overall survival in patients treated with breast-conserving surgery and adjuvant external beam radiation therapy.

3-D printed facial prosthesis offers new hope for eye cancer patients after surgery

By utilizing both facial scanning software and 3-D printing, researchers have developed an inexpensive way to make facial prostheses for patients with eye cancer.

Telephone counseling sessions increase likelihood that childhood cancer survivors receive cardiac screening

Telephone counseling sessions increase likelihood that childhood cancer survivors receive cardiac screening

Written heart screening guidelines plus telephone counseling doubled the probability of childhood cancer patients receiving cardiac monitoring.

Treatments and survival benefits compared for early stage lung cancer

Removal of an entire lung lobe may offer patients with early stage lung cancer better overall survival compared with a partial resection.

Cancer prehabilitation: One step toward improved outcomes

Cancer prehabilitation: One step toward improved outcomes

As cancer care evolves toward anticipatory rather than reactionary care, oncology nurses should consider developing important new skills.

Advances in creating treatment for common childhood blood cancer

Advances in creating treatment for common childhood blood cancer

A new drug in development may offer analternative to standard chemotherapy for patient with T-cell acute lymphoblastic leukemia, according to new research.

Subsidies help breast cancer patients adhere to hormone therapy

A federal prescription-subsidy program for low-income Medicare recipients has increased adherence to hormone therapy to prevent breast cancer recurrence after surgery, according to recent data.

Fertility preservation research project seeks to serve young boys with cancer

Young men who have a high risk of becoming sterile the option to bank a small piece of testicular tissue prior to cancer treatment.

Poor staging linked to mortality in bladder cancer

Poor staging linked to mortality in bladder cancer

In cases of bladder cancer, omission of muscle in specimen or its mention in pathology report is linked to increased mortality.

Dramatic response and resistance to cancer drug traced to unsuspected mutations

Examination of the DNA of a thyroid cancer survivor has revealed details about resistance to the drug everolimus, according to researchers.

New treatment for retinoblastoma expected to save more eyes from cancer

A new technique to treat retinoblastoma may help prevent eye loss, blindness, or death in children with advanced forms of the disease.

Achieving clinical trial participation through cooperative networks

Achieving clinical trial participation through cooperative networks

Clinical trials could benefit from a greater number of participants with a dedicated cooperative network to support rural community cancer centers.

Lung cancer can stay hidden for 20+ years

Lung cancer can remain dormant in the body for many years before emerging in an aggressive form, according to new research.

Improved tyrosine kinase inhibitor (TKI) selectively activates in tumor tissue, minimizing side effects in patients

A new strategy developed by an interdisciplinary team of researchers aims to reduce the side effects connected to use of tyrosine kinase inhibitors (TKIs).

Immunotherapy added to radiotherapy may help overcome resistance to treatments

Immunotherapy added to radiotherapy may help overcome resistance to treatments

Coupling immunotherapy to radiotherapy treatment could help prevent cancers from becoming resistant to treatment, according to a new study.

Current therapy for hypothyroidism endorsed by new guidelines

A recent review has found insufficient consistent data exist to recommend a change in use of levothyroxine as the only drug needed to treat hypothyroidism.

Importance of sequence in chemotherapy administration

Importance of sequence in chemotherapy administration

Is sequencing important when administering chemotherapy on the same day?

Nearly 5 percent of cancer patients die a month after surgery

Nearly 5 percent of cancer patients die a month after surgery

In a study of more than 1.1 million cancer patients who had surgery, almost 5 percent died within one month of their operation. Lack of access to quality care a major factor in these deaths, researchers say.

High-dose radiotherapy doesn't offer survival benefit in mesothelioma

Treatnent with high-dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to phase II trial data.

Cediranib added to chemotherapy improves progression-free survival in cervical cancer

Addition of the experimental drug cediranib to standard chemotherapy improves tumor shrinkage and adds a modest improvement in progression-free survival for patients with cervical cancer that has recurred after treatment.

Afatinib improves progression-free survival in head and neck cancer

After failure of platinum-based chemotherapy, the tyrosine kinase inhibitor (TKI) afatinib significantly improved progression-free survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Using guideline adherence to manage CINV effectively

Using guideline adherence to manage CINV effectively

Guidelines for managing chemotherapy-induced nausea and vomiting direct management toward risk assessment and prophylactic antiemetics.

Elevated cholesterol associated with prostate cancer recurrence

Elevated cholesterol associated with prostate cancer recurrence

Findings suggest that elevated levels of cholesterol and triglycerides may be linked with greater risk of the prostate cancer recurrence, but normalization of blood fats may reduce risk.

HER2 inhibition shows promise in HER2-positive non-small cell lung cancer

Human epidermal growth factor receptor 2 (HER2) mutations may offer an important treatment target in a subset of patients with non-small cell lung cancer.

Good news for young patients with a leukemia subtype with poor prognosis

Good news for young patients with a leukemia subtype with poor prognosis

For younger patients with an acute lymphoblastic leukemia (ALL) subtype, modifying treatment based on chemotherapy response can make a vital difference.

Good bowel cleansing key for high-quality colonoscopy

Successful colonoscopy is closely dependent on good bowel preparation, and poor bowel prep often leads to missed precancerous lesions.

An episode of sudden-onset jaundice signaled pancreatic cancer in a healthy man

An episode of sudden-onset jaundice signaled pancreatic cancer in a healthy man

After surviving pancreatic cancer, a patient learns the disease metastasized to his liver. But this patient was not ready to give up. With the support of a liver surgeon, he underwent surgery and beat his disease.

E-cigarettes not helpful in smoking cessation among cancer patients

E-cigarettes not helpful in smoking cessation among cancer patients

Smokers with cancer using e-cigarettes (in addition to traditional cigarettes) were found to be more nicotine dependent and equally or less likely to have quit smoking traditional cigarettes than nonusers.

Combination treatment for melanoma achieves significant progression-free survival and response rates

Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieved superior results over vemurafenib plus placebo for BRAF-mutation positive melanoma.

Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) study confirms use of trastuzumab for HER2-positive breast cancer

The use of trastuzumab (Herceptin) as the standard-of-care treatment for HER2-positive breast cancer has been supported by the Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization (ALTTO) study.

Tool successfully distinguishes between breast cancer and normal tissues

Researchers have successfully tested a new tool that will help surgeons better distinguish cancerous breast tissue from normal tissue, which should lower the mount of repeat procedures needed.

Targeted combination therapy halts disease and extends life in advanced melanoma

A targeted combination drug therapy has shown efficacy for metastatic melanoma, showing reduction in both mortality and disease progression.

New antifungal is as effective as existing drugs and with fewer adverse events

A newly developed antifungal has proved as effective against invasive mold disease in cancer patients as the standardly used drug, voriconazole, with fewer side effects.

Ortho-oncology team achieves successful hip articulation by repurposing a shoulder surgical aid

A shoulder surgical aid, known as the Spider Limb Positioner, was adapted successfully to conduct a left hip disarticulation on a patient with melanoma.

Improved survival for inoperative liver cancer through a combined therapy

Patients that have inoperable advanced hepatocellular carcinoma (HCC) may live significantly longer by receiving a combined therapy, according to recent trial results.

Once-weekly breast radiation regimen improves on current treatment

An experimental regimen of once-weekly breast irradiation after lumpectomy provides more convenience to patients at less expense, and results in better completion rates of prescribed radiation treatment.

ESMO: Combination treatments increase metastatic melanoma survival

ESMO: Combination treatments increase metastatic melanoma survival

Studies show improved progression-free melanoma survival for both cobimetinib combined with vemurafenib, and dabrafenib combined with trametinib.

Prostate cancer treatment controversy continues as study finds watchful waiting not enough for some men

An active controversy among oncologists concerns watchful waiting versus more active treatment for prostate cancer.

Concurrent radiation and chemotherapy after surgery effective in high-risk endometrial cancer

Radiation therapy with concurrent paclitaxel chemotherapy after surgery can be effective to treat patients with high-risk endometrial cancer, according to new research.

Evidence-based design: A new concept in health care facilities that puts the focus on patients

Evidence-based design: A new concept in health care facilities that puts the focus on patients

A medical center in New Jersey makes the most of a rare opportunity to rebuild from the ground up. Its innovative patient rooms follow evidence-based design, a new concept in health care architecture.

Olaparib tablet safe in patients with ovarian cancer who received pretreatment

A PARP inhibitor in oral tablet form, given in combination with chemotherapy, was deemed safe for heavily pretreated patients with ovarian cancer.

E-cigarettes don't help cancer patients stop smoking

E-cigarettes don't help cancer patients stop smoking

Smokers with cancer who used e-cigarettes along with traditional cigarettes were more dependent on nicotine, and the long-term safety of the devices still unclear, researchers caution.

Indeterminate melanoma cases reduced by three-quarters by diagnostic test

Malignant melanoma was differentiated from benign skin lesions with high accuracy in a pivotal clinical utility study of the Myriad myPath Melanoma test.

For cancer patients, e-cigarettes not helpful for smoking cessation

For cancer patients, e-cigarettes not helpful for smoking cessation

Patients with cancer who use e-cigarettes as a form of smoking cessation are equally or less likely to quit smoking.

AACR: Targeted drugs and prevention reduce cancer mortality

AACR: Targeted drugs and prevention reduce cancer mortality

About 14.5 million U.S. cancer survivors are alive today, but aging population and increasing obesity threaten progress.

Better classifications improve treatment planning for breast cancer

Scientists have developed a tool to distinguish each breast cancer subtype, research that could improve treatments and targeting of treatments for the disease.

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

ASTRO: Prostate cancer recovery faster with less androgen deprivation therapy

Shorter time to testosterone recovery with 18 versus 36 months androgen deprivation therapy.

Tumor cells prep lymphatic cells to encourage breast cancer cells to spread

Breast cancer cells can lay the groundwork for their own metastasis throughout the body by coaxing cells within lymphatic vessels to send out tumor-welcoming signals.

Protein deletion predicts length of progression free survival (PFS) in patients with non-small cell lung cancer (NSCLC)

Deletion of the Bcl-2-like protein 11 (BIM) in advanced non-small cell lung cancer has been associated with shorter progression free survival (PFS).

Risk of premature menopause after Hodgkin lymphoma treatment is mapped

Women treated for Hodgkin lymphoma will be able to better understand their risks of future infertility after researchers estimated their risk of premature menopause with different treatments.

Patient and tumor characteristics in melanoma examined for clues to aggressive form of disease

Researchers in Australia examined patient and tumor characteristics of melanomas for higher mitotic rates (a marker of tumor cell growth) in an effort to increase early detection.

For black men with prostate cancer, watchful waiting may be unwise

For black men with prostate cancer, watchful waiting may be unwise

For men with early-stage prostate cancer, watching waiting is not always the best course of action, especially for black patients.

Irinotecan promising in some patients with stage III colon cancer

A subset of patients with stage III colon cancer had improved survival rates when treated with irinotecan-based therapy, according to recent research.

Weekend hospitalization linked to longer stays for pediatric patients with leukemia

Weekend hospital admission for pediatric patients with newly diagnosed leukemia is associated with a longer length of stay, slightly longer wait to start chemotherapy, and higher risk for respiratory failure.

Soy may be detrimental for women with breast cancer

Soy may be detrimental for women with breast cancer

Study raises questions about the effect of soy's estrogen-like properties.

Biomarker highly promising for predicting breast cancer outcomes

A protein named p66ShcA shows promise as a biomarker to identify breast cancers with poor prognoses, according to new research.

Opioid-related deaths are almost 25% lower in states with medical marijuana laws

Rates of death resulting from opioid analgesic overdoses are lower in states that allow medical use of marijuana compared with states without such laws.

Surgery associated with better survival for patients with advanced laryngeal cancer

Patients with advanced laryngeal cancer appear to have better survival if they are treated with surgery than with nonsurgical chemoradiation.

Natural killer cells battle pediatric leukemia

Natural killer cells battle pediatric leukemia

A select team of immune-system cells from patients with leukemia can be multiplied in the laboratory, creating a horde of natural killer cells that can be used to target and destroy the cancer cells.

Factors associated with late hospice admission for cancer patients identified

Factors associated with late hospice admission for cancer patients identified

For patients with cancer, late admission more likely for younger patients, married men, hematologic malignancies.

Promising results from trial for late-stage peritoneal cancers

A drug originally used to treat ovarian cancer has shown promising results in patients with advanced peritoneal cancers during a phase I clinical trial.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs