Telomere length is predictive for determining which children treated for AML are at highest risk for delayed recovery, a finding that may have significant implications for treatment-related morbidity and mortality.
Improved cancer detection and advances in treatment mean larger numbers of older cancer patients are becoming survivors, combined with demographic trends. But older patients are underrepresented in clinical trials.
In addition to improving overall survival compared with dacarbazine in patients with advanced melanoma, nivolumab maintains baseline levels of health-related quality of life to ultimately confer long-term quality of survival benefit.
In a large cohort of hematologic oncologists surveyed in the United States, standard end-of-life quality measures were highly acceptable, but unrealistic patient expectations are the greatest impediment to quality end-of-life care.
Memory problems in breast cancer survivors appear associated with the high stress load these patients experience rather than their treatment, and moderate-to-vigorous physical activity may help subjective memory in these patients.
Lung cancers that manifest as nonsolid nodules seem to have indolent course, according to recent research data.
Relaxing acupressure resulted in significant improvement in persistent fatigue, sleep quality, and quality of life among survivors of breast cancer, a recent study has shown.
The Patient-Owned Survivorship Transition Care for Activated, Empowered survivors (POSTCARE) intervention resulted in clinically meaningful improvements in 3 domains of quality of life (QoL) among survivors of breast cancers.
A group of researchers sought to examine the physical functioning of patients with breast cancer, in various age brackets, who were enrolled in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) phase III trial.
Likelihood of other chronic conditions will stress health care system in next two decades, as more patients with cancer live longer.
Nearly 1 in 12 patients with a cancer from the 10 most common cancer sites developed a second primary neoplasm during survivorship.
Many Older Women With Early Stage Breast Cancer Are Susceptible to Functional Decline After Starting Treatment
Approximately 20% of older women with stage I-III breast cancer lost the ability to complete some basic tasks of independent living within 1 year of starting treatment. However, an assessment tool can identify those women at greatest risk of posttreatment functional decline.
Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.
Recent results from a multicenter, phase 2 trial suggest that patients with HIV and aggressive lymphoma should receive autologous stem cell transplant as standard of care. Risk of serious complications after transplant in these patients is equal to that of patients without HIV.
Undergoing pleurectomy and decortication for malignant pleural mesothelioma generally leads to improved quality of life after the surgery.
Cancer and dementia patients get more access to palliative care than do patients with many other chronic conditions, recent research indicates.
Ibrutinib treatment for chronic lymphocytic leukemia with the deletion of chromosome 17p (del17p CLL) increases the percentage of patients alive at 30 months over other therapies for del17p CLL.
In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.
Event-free survival for adult patients with ALL has improved from 40% to 73% with the implementation of the NOPHO ALL 2008 protocol in July 2008.
Adjuvant chemotherapy in patients with stage Ib non-small cell lung cancer improved overall survival and 5-year overall survival.
The number of patients older than 75 years who do not undergo surgery is increasing, especially among those with stage III or IV ovarian cancer. Approximately 50% do not undergo surgery and 25% receive no treatment at all.
New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases
Researchers demonstrate how breast cancer cells invade bone marrow, where they escape chemotherapy and hormonal therapies that would otherwise eliminate the cancer cells.
Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.
A post-hoc analysis of the Phase 3 ASPIRE study indicates that treatment combining carfilzomib with lenalidomide and dexamethasone extended survival time for patients with multiple myeloma.
Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer
Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.
A decreasing number of adolescents are smoking, but e-cigarette use and rates of distracted driving are on the rise for this group.
Researchers found tracking symptoms and alerting doctors to problems early led to longer survival for patients with lung cancer.
Physical exercise may have a direct effect on cancer that is as effective as drugs for treating patients with prostate cancer, even for those with advanced stages of the disease.
Three in four of young or middle-aged patients with terminal cancer receive aggressive therapies in their last months of life.
At 3 years, 40% of patients with advanced melanoma treated with pembrolizumab are alive regardless of whether they had been treated with ipilimumab or not, follow-up results from the KEYNOTE-001 study reported at the ASCO 2016 Annual Meeting.
The longest overall survival follow-up among randomized phase 3 trials evaluating BRAF and MEK inhibitors in patients with BRAF-mutant metastatic melanoma to date has shown the best 3-year outcome with dabrafenib plus trametinib to be in patients with normal LDH and fewer than 3 disease sites, according to a presentation at the ASCO 2016 Annual Meeting.
NETTER-1 trial results of the somatostatin analogue peptide, 177Lu-DOTA0-Tyr3-octreotate (177Lu-Dotatate), suggest a potential survival benefit in patients with advanced midgut neuroendocrine tumors (NETs), attendees at the ASCO 2016 Annual Meeting were told.
Greatest survival benefit observed for those taking the drug before their cancer diagnosis.
Tailored dose-dense chemotherapy significantly improved event-free survival and also showed efficacy in relapse-free and overall survival compared with standard adjuvant chemotherapy in patients with high-risk breast cancer, according to results of the phase 3 PANTHER study reported at the 2016 ASCO Annual Meeting.
Lenalidomide maintenance after high-dose melphalan and autologous stem cell transplant (ASCT) significantly prolonged overall survival in patients with multiple myeloma compared with no maintenance, a meta-analysis of 3 randomized controlled trials presented at the 2016 ASCO Annual Meeting has found.
The introduction of palliative care shortly after a patient is diagnosed with cancer is associated with improved quality of life.
Patients whose treatment was based on the molecular characteristics of their particular tumor had significantly better outcomes compared with patients who did not.
Four in 10 patients with newly diagnosed and previously treated advanced melanoma were alive 3 years after initiating pembrolizumab.
Radiation therapy delivered to the critical vessels surrounding the prostate can result in erectile dysfunction and bladder and renal irritation. Vessel-sparing radiation and an improved understanding of the anatomy of the prostate can reduce these effects.
Including Quality Measures In Treatment Regimens Increases Survival in Stage IIIA Non-Small Cell Lung Cancer
When more quality measures are incorporated into patient care, survival rates for patients with stage IIIA non-small cell lung cancer (NSCLC) increase, but only 13% of eligible patients actually receive all 4 recommended quality measures.
Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer
Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.
Results from this study showed that 5-year survival for older patients after surgery for lung cancer is favorable. Based on these results, surgeons might be better equipped to individualize care for this older population.
Radiotherapy in combination with anti-androgen hormone therapy halves the risk of death from prostate cancer 15 years after diagnosis compared with hormone therapy alone.
A recent study examined depression and anxiety among family caregivers of patients with incurable cancer and sought to identify factors linked to these symptoms.
Chronic conditions commonly affect long-term quality of life for survivors of childhood cancer who are in their young adult years.
The immunotherapy drug nivolumab conferred a survival benefit in patients with head and neck cancer over standard chemotherapy.
The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.
Swallowing the liquid nicotine appears to affect children under 6 the most, and calls to poison control centers about accidental ingestion have sharply increased.
Video-assisted thoracoscopic surgery (VATS) is associated with less postoperative pain and better quality of life than anterolateral thoracotomy for the first year of surgery in patients with stage I NSCLC.
Delayed radiation therapy (RT) after surgery significantly increased the risk of recurrent disease in women treated for very early breast cancer.
A low-dose of aspirin could increase survival by up to 20% and help stop metastasis for patients receiving cancer treatment.
Progression-free-survival was improved in all prespecified patient groups, including those with high-risk cytogenetic abnormalities.
E-cigarettes have a strong potential to improve population health by reducing or displacing cigarette use. A team of international experts urged the US FDA to have a broad perspective when it comes to regulating e-cigarettes.
An AYA patient survivorship program jointly designed by a cancer institute and a community organization educates patients about their oncologic history and the effects of therapy, as well as provides resources to improve quality of life.
Socioeconomic status and features of physical health rather than tumor characteristics were associated with symptoms of depression among long-term survivors of colorectal cancer.
Longer survival was achieved with stereotactic radiosurgery (SRS) alone than with whole-brain radiation therapy (WBRT) in patients with fewer than 4 brain metastases from NSCLC or breast cancer.
The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.
Continuation of ceritinib therapy beyond disease progression was associated with prolonged survival, according to results from a retrospective study of the use of ceritinib to treat advanced ALK-positive NSCLC.
Smokers who visit a clinician for lung cancer screening should also be encouraged to quit smoking at that visit. Evidence-based behavioral strategies should be used, at each visit, to motivate smokers to quit.
Researchers found that men with prostate cancer who had exercised regularly had the best outcomes.
A study examined the relation between various forms of breast cancer therapies and risk of congestive heart failure.
Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.
Older women with diabetes and cancer taking metformin saw an increase in survival.
New technology has enabled doctors to administer higher doses of radiation to prostate cancer tumors with fewer side effects; however, escalating the dose of radiation may not help patients with localized prostate cancer in the long term.
Patients with classical Hodgkin lymphoma who are resistant to the CD30-directed antibody-drug conjugate brentuximab vedotin have poor outcomes.
Site of metastasis is key to the length of time a patient can survive metastatic castration-resistant prostate cancer (mCRPC).
Higher Treatment Volumes at Radiation Facilities Lead to Improved Overall Survival in Prostate Cancer
Among men with aggressive prostate cancer, overall survival (OS) rates improve when they receive radiation treatment at facilities that frequently perform the treatment.
Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia
Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.
Prolonged nightly fasting may reduce the risk of recurrence for patients with breast cancer.
The Samfund is a not-for-profit organization dedicated to easing the lasting financial effects of cancer treatments for young adults with the disease.
A complex surgical procedure to remove the prostate achieves excellent long-term survival for men with prostate cancer after radiation therapy has failed.
A weekly dose of temsirolimus 75 mg was found to be active in patients with relapsed/refractory primary CNS lymphoma (PCNSL); however, only some patients achieved long-term control.
Among women aged up to 49 years with a pregnancy-associated melanoma, recurrence rates were higher than seen in other groups.
Patients who have had cancer recently can still be treated with antibodies against tumor necrosis factor for inflammatory bowel disease.
Study Findings Show Possible Association Between PreLabor Cesarean Delivery and Risk for ALL in Young Children
The finding that prelabor cesarean delivery may have a correlation with acute lymphoblastic leukemia (ALL) may offer new targets for research into preventing cancer.
Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma
Female survivors of childhood Hodgkin lymphoma (HL) who received chest radiation can reduce their risk of breast cancer through early screening.
High neutrophil to lymphocyte ratio (NLR) is linked to worse prognosis in Caucasian patients with early breast cancer.
Reliance on PET to Detect Lung or Esophageal Cancer Recurrence May Lead to Overuse of the Imaging Modality
In posttreatment follow-up of lung and esophageal cancer, PET scans might be overused to detect cancer recurrence. Furthermore, PET scan use to detect recurrence does not increase survival.
Chemotherapy agents commonly used to treat childhood cancer impair eyesight in a way that indicates an impact on the CNS. The damage occurs to the patient's eye motor skills.
Immense financial challenges confront young adults with cancer. As a result of medical bills and the loss of savings, these patients may forgo recommended medications and/or follow-up appointments.
Survival rates are not increased and the likelihood of receiving a full course of radiation is decreased for patients with locally advanced head and neck cancer who receive IC rather than the standard treatment of CRT.
Unmet health information needs, even nearly a decade after a cancer diagnosis, were a key finding of a study of the needs of cancer survivors who are at least 9 years beyond an initial diagnosis.
As the American College of Surgeons' Commision on Cancer milestones approach, ASTRO publishes a template to ensure consistent, comprehensive survivorship care plans can be developed for cancer survivors whose treatment involved radiotherapy.
Researchers have noted a link between supportive care and reduced risk of adverse outcomes.
Posttreatment imaging at 3 months and physical examinations during the 6 months following treatment can detect most recurrences in patients treated with definitive radiation therapy for HPV-associated oropharyngeal cancer.
Paclitaxel administered with carboplatin on a weekly basis is not associated with improved progression-free survival.
Pediatric survivors of ALL treated only with chemotherapy remain at an increased risk for attention problems 2 years after treatment cessation.
A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.
A significant decrease in muscle area was seen in patients with metastatic colorectal cancer (mCRC) receiving chemotherapy, which was independently associated with survival in these patients.
Depressive Symptoms Linked to Worse Survival Following Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery
A study examined the relationship between depression and survival for patients undergoing hyperthermic intraperitoneal chemotherapy combined with cytoreductive surgery.
The intensity of end-of-life care for patients with myelodysplastic syndromes may be optimal in terms of hospice use, a recently published study has shown.
An exercise intervention did not improve physical functioning for women living with advanced breast cancer, according to a study.
Osteosarcoma in children may be impacted by a defect in DNA imprinting that also occurs in their biological parents. These imprinting defects may be predictive of survival outcomes.
Most patients with resected non-small cell lung cancer (NSCLC) preferred a collaborative role in decision-making about adjuvant chemotherapy.
Hematopoietic cell transplantation (HCT)-related concerns at the time of hospital discharge predict increases in depression but not in anxiety.
After experiencing the benefits of meditation to help himself cope with the stress of caring for patients with cancer, this oncologist leads classes teaching those patients to use the tool to better cope with their disease and its effects.
Patients with cancer, including those with a tobacco-related cancer, do not seem to be more likely to quit smoking than the general population.
Men with prostate cancer and bone metastases that have experienced at least one skeletal-related event (SRE) show worse survival, according to a recent study.
Smokers have good reason to quit the habit both before and after a breast cancer diagnosis.
[OncoTargets and Therapy] Anaplastic large cell lymphoma (ALCL) frequently involves the bone marrow, but primary or secondary involvement to the bone is rare. This article examines a case of anaplastic lymphoma kinase positive ALCL with prominent bone involvement in a young boy.
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- High-Fat Mediterranean Diet Can Protect Against Cancer
- Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers
- HPV Vaccination Program Reduces Cervical Cell Anomalies in Young Women
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Implementing a Distress Screening Process for Cancer Patients
- Initiating Palliative Care in the Emergency Department
- Helical APBI Delivers Targeted Dose of Adjuvant Radiation Treatment for Breast Cancer
- Cancer Risk Higher in Patients With Heart Failure After a First Heart Attack
- Routine Pap Smears Improve Cervical Cancer Risk in Women Older Than 65 Years
- Second-Line Regorafenib Improves Overall Survival in Refractory Liver Cancer
- Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries
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