Cause of resistance to PI3K-alpha inhibitor identified

In women with breast cancer, loss of the tumor suppressor PTEN was a frequent cause of resistance to the investigational drug BYL719, which blocks the activity of a protein called PI3K-alpha.

Aspirin linked to improved survival after colon cancer diagnosis

Aspirin linked to improved survival after colon cancer diagnosis

Taking low doses of aspirin, which inhibits platelet function, after a colon cancer diagnosis appears to be associated with better survival if the tumor cells express HLA class I antigen.

Y-90 radioembolization: A new treatment for hepatic metastases from breast cancer

Yttrium-90 radioembolization is a minimally invasive treatment that may slow disease progression in breast cancer that has metastasized to the liver.

Doxorubicin-ifosfamide combo improves progression-free survival in soft-tissue sarcoma

A new European study does not support administration of intensified doxorubicin and ifosfamide for palliation of advanced soft tissue sarcoma.

New gene implicated in progression and recurrence of triple-negative breast cancer

A gene not previously associated with breast cancer appears to play a pivotal role in the growth and progression of triple-negative breast cancer.

Certain genetic variants increase recurrence risk for bladder cancer

Inheriting certain DNA sequences can affect the prognosis of bladder cancer patients, according to a new study.

Faster cognitive decline lowers cancer mortality risk

Faster cognitive decline lowers cancer mortality risk

Elderly with faster cognitive decline were found to have lower risk of cancer mortality, according to research.

Potentially curative surgery for localized pancreatic cancer is underutilized

Surgical resection of early-stage pancreatic tumors has the potential to cure patients with this deadly disease but continues to be underutilized, according to a new national analysis.

Mindfulness-based meditation may help teenagers cope with cancer

Mindfulness-based meditation may help teenagers cope with cancer

Mindfulness-based meditation could lessen some symptoms associated with cancer in teens, including depression and sleep quality in girls, according to the results of a preliminary study.

Lack of sleep, increased stress are common maternal experiences after a child's ALL treatment

Even months after their child's acute lymphoblastic leukemia diagnosis and treatment, 46% of mothers still exhibited symptoms of clinical anxiety, and 26% of mothers showed depressive symptoms.

Health gap between childhood cancer survivors and siblings widens with age

Adult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers.

Exceptional response to everolimus is reported in patient with bladder cancer patient

A patient with advanced bladder cancer experienced a complete response to the drug combination everolimus and pazopanib in a phase 1 clinical trial. Genomic profiling revealed information that could help identify other patients who may respond to everolimus and pazopanib.

Early detection of childhood eye cancer does not improve survival or prevent eye loss

Shortening the time from first appearance of symptoms to diagnosis has no bearing on survival or stage of disease in unilateral retinoblastoma, the most common form of childhood eye cancer, according to a new study.

Steep drop in colon cancer incidence seen among older Americans

Colon cancer incidence rates have dropped 30% in the United States in the last 10 years among adults 50 years and older, the largest decrease in people older than 65 years.

Primary androgen deprivation ineffective for most early prostate cancer

In a study of men with early stage prostate cancer, those who received androgen deprivation as their primary treatment instead of surgery or radiation did not live any longer than those who received no treatment.

High adenoma detection rate lowers interval colorectal cancer risk

High adenoma detection rate lowers interval colorectal cancer risk

Adenoma detection rate is inversely associated with risk of interval colorectal cancer.

DNA methylation markers ID bladder cancer recurrence

DNA methylation markers ID bladder cancer recurrence

For patients with noninvasive urothelial carcinoma, three DNA methylation markers are able to accurately predict tumor recurrence, according to a study.

Radiotherapy after mastectomy improves outcomes for patients with up to three positive lymph nodes

Women whose breast cancer has spread to just a few axial lymph nodes are less likely to have their disease recur or to die from it if they have radiotherapy after mastectomy.

Genetic testing selects patients with ER+ breast cancer for extended hormone therapy

Genetic testing selects patients with ER+ breast cancer for extended hormone therapy

Genetic analyses of results from postmenopausal women being treated for estrogen-responsive breast cancer have shown that some are more likely to have a late recurrence of their cancer and might benefit from additional years of hormone therapy.

Chemotherapy-free treatment a possibility for leukemia/lymphoma

Patients with terminal forms of leukemia and lymphoma who have run out of treatment options could soon benefit from a new drug, which not only puts an end to chemotherapy and has virtually no side effects.

Early relapse risk is higher when omitting radiotherapy in PET-negative early Hodgkin lymphoma

The risk of early relapse is increased when radiotherapy is omitted in patients with stage I/II Hodgkin lymphoma whose PET scan findings are negative, according to an interim trial analysis.

New approach reduces opioid painkiller use after breast reconstruction surgery

A new approach to breast reconstruction surgery aimed at helping patients' bodies get back to normal more quickly cut their postoperative painkiller use in half and reduced hospital stay, a new study found.

Long-term quality of life is good after esophagectomy and gastric pull-up

Long-term survivors can enjoy a satisfying meal and good quality of life after esophagectomy with gastric pull-up, according to a new study.

Molecular test prompts changes in prostate cancer treatment plans

The PROCEDE 500 study demonstrated that 65% of physicians changed their original treatment plans for men with prostate cancer based on results from the Prolaris test.

Bone turnover markers predict prostate cancer outcomes

Bone turnover markers predict prostate cancer outcomes

Biomarkers for the formation and resorption of bone predict outcomes for men with castration-resistant prostate cancer (CRPC).

Younger men benefit most from surgery for localized prostate cancer

Younger men benefit most from surgery for localized prostate cancer

A new study found substantial long-term reduction in mortality for men with localized prostate cancer who undergo a radical prostatectomy.

E-cigarette use does not accelerate smoking cessation

E-cigarette use does not accelerate smoking cessation

Baseline e-cigarette use does not significantly predict quitting smoking one year later or reduce cigarette consumption after one year, according to a study.

Elevated morbidity long-lasting for childhood cancer survivors

Elevated morbidity long-lasting for childhood cancer survivors

The increased risk of a severe, disabling, life-threatening, or fatal health condition persists to age 50 years for many childhood cancer survivors.

Key protein identified that helps prevent lung cancer tumors from being destroyed

Eliminating the protein Mcl-1 could make radiation and chemotherapies more effective in treating the most common and deadly of all cancers, non-small cell lung cancer.

Investigational drug may increase survival of advanced melanoma

An experimental drug aimed at restoring the immune system's ability to spot and attack cancer halted cancer progression or shrank tumors in patients with advanced melanoma, according to an early-phase clinical trial.

Epigenetic imprint of chemotherapy linked to inflammation in breast cancer survivors

Chemotherapy, one of the major treatments for breast cancer, can leave a long-lasting epigenetic imprint in the DNA of the blood cells of breast cancer patients, according to new research.

SGO: High-volume centers associated with gynecologic cancer survival

SGO: High-volume centers associated with gynecologic cancer survival

For women with gynecologic cancers, treatment at high-volume centers is associated with a survival advantage.

Earlier palliative care improves quality of life

Earlier care improves quality of life and patient satisfaction, according to the results of the first clinical study to assess the impact of providing early outpatient palliative care versus standard oncology care.

Reducing radiation therapy dose to bilateral submandibular lymph nodes improves salivary function

For head and neck cancer patients undergoing radiation therapy, a reduction in the amount of radiation treatment volume to the submandibular (level IB) lymph nodes resulted in better patient-reported salivary function.

No survival improvement from bevacizumab for patients with newly diagnosed glioblastoma

Adding bevacizumab (Avastin) to standard chemotherapy and radiation treatment does not improve survival for patients with newly diagnosed glioblastoma, an often deadly brain cancer, researchers reported.

Favorable outcomes from unilateral radiation therapy for advanced tonsil cancer

Limiting radiation therapy to lymph nodes on one side of the neck for advanced tonsil cancer resulted in good local regional control and no cancer recurrence on the untreated side, according to new research presented at the 2014 Multidisciplinary Head and Neck Cancer Symposium in Scottsdale, Arizona.

Hypnosis therapy decreases fatigue in breast cancer patients

Hypnosis therapy decreases fatigue in breast cancer patients

Breast cancer patients receiving radiotherapy showed decreased fatigue as a result of cognitive behavioral therapy plus hypnosis, according to a new study.

Feasible and safe to limit radiation to major salivary glands in HNCs

Avoiding the contralateral submandibular gland during radiation therapy is feasible and safe with advanced stage, node-positive head and neck cancers and base of tongue lesions, according to new research.

Patients with oropharyngeal cancer report quality of voice and speech affected posttreatment

Oropharyngeal cancer patients treated with combined chemotherapy and radiation therapy reported a decrease in their voice and speech quality for up to a year after the completion of treatment.

HPV status and intra-tumor heterogeneity mark improved patient outcomes in HNSCC

Combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with a patient's HPV status provides an effective indicator of improved patient outcome.

Genetically modified T cells eradicate advanced leukemia

The largest clinical study ever conducted to date of patients with advanced leukemia found that 88% achieved complete remission after being treated with genetically modified versions of their own immune cells.

Gene sequencing discovers common driver of childhood brain tumor ependymoma

Gene sequencing discovers common driver of childhood brain tumor ependymoma

The most common genetic alteration ever reported in the brain tumor ependymoma has been identified. Researchers also have evidence that the alteration drives tumor development.

Targeted drug may prolong survival for patients with cervical cancer

A new clinical study has found that erlotinib has promising potential to improve treatment for cervical cancer.

New first-line option for follicular lymphoma explored

The use of radioimmunotherapy treatment in patients with newly diagnosed follicular lymphoma has been investigated in a new study.

Bevacizumab promising for advanced cervical cancer

Research has revealed that women with advanced cervical cancer live about 4 months longer with the combined use of bevacizumab and chemotherapy compared with chemotherapy alone.

Secondary thyroid cancer more deadly than primary malignancy in younger patients

A new analysis has found that adolescents and young adults who develop thyroid cancer as a secondary cancer have a significantly greater risk of dying than those with primary thyroid cancer.

Personalized medicine is the ideal way to treat cancer

Assessing the route to cancer on a case-by-case basis might make more sense than basing a patient's cancer treatment on commonly disrupted genes and pathways, according to a new study.

Prognostic factors of pazopanib in advanced soft tissue sarcomas

A new analysis confirmed the importance of known prognostic factors such as performance status and tumor grading for having a long-term outcome in patients treated with pazopanib for metastatic soft tissue sarcoma. In addition, hemoglobin at baseline was found to be a new prognostic factor.

Cancer care costs can be reduced without risk to patients

Experts have identified three major sources of high cancer costs and argue that cancer doctors can likely reduce them without harm to patients. The cost-cutting proposals call for changes in routine clinical practice involved in end-of-life care, medical imaging, and drug pricing.

Yoga increases QoL for breast cancer patients receiving radiotherapy

Yoga increases QoL for breast cancer patients receiving radiotherapy

For women with breast cancer, incorporating yoga into radiotherapy is associated with a lasting improvement in quality of life.

Breast cancer survival predicted by gene panel linked to powerful tumor suppressor

Breast cancer survival predicted by gene panel linked to powerful tumor suppressor

A panel of 55 genes, almost all of which are impacted by the loss of a particular protein, appears to predict if breast cancer will become invasive.

Nivolumab may extend advanced melanoma survival

Nivolumab may extend advanced melanoma survival

Acceptable long-term safety, positive therapy responses persist after drug discontinuation

Silicone dressing prevents skin reactions during radiation

Severe skin reactions during radiation therapy could be prevented by applying a thin transparent silicone dressing to the skin from the first day of treatment, according to clinical research from New Zealand.

Nurse education and workload affect patient mortality

Nurse education and workload affect patient mortality

An increase in workload increases odds of death, whereas an increase in percentage of nurses with degrees cuts death rates, research found.

Delivery model for cancer care intelligently redesigned

Delivery model for cancer care intelligently redesigned

Recent articles discussed the need to develop both a learning IT system for cancer that enables real-time data analysis from cancer patients in a variety of care settings.

Cancer deaths continue to decline

Cancer deaths continue to decline

The American Cancer Society (ACS) has published its latest annual report on cancer incidence and mortality, and the news is good.

Earlier ovary removal increases BRCA-associated survival

Earlier ovary removal increases BRCA-associated survival

Among women with mutations in BRCA1 or BRCA2, oophorectomy reduces the risk of developing ovarian, fallopian tube, or peritoneal cancer by 80 percent.

Multiple biopsies increase infection risk for prostate cancer patients

Multiple biopsies increase infection risk for prostate cancer patients

Men with prostate cancer on active surveillance should be informed of the risk of complications linked to repeated biopsies.

Chemical stem cell signature predicts treatment response for acute myeloid leukemia

A chemical signature has been found in blood-forming stem cells that predict if a patient with acute myeloid leukemia (AML) will respond to chemotherapy.

Black History Month calls attention to disparity in cancer rates

Half of African-American men and a third of African-American women will receive a diagnosis of cancer in their lifetimes. The causes of cancer health disparities are complex, stemming from such factors as genetic susceptibility and family history.

High diagnostic accuracy with simple, at-home test for colorectal cancer

Tests that require patients to collect a single stool sample at home and then send it to a lab for analysis will detect about 79% of colorectal cancers. A review of 19 studies examining eight different FITs also finds that the tests will correctly identify about 94% of patients who do not have cancers of the rectum or colon.

Adjuvant bevacizumab increases cervical cancer survival

Adjuvant bevacizumab increases cervical cancer survival

Adjuvant bevacizumab increases overall survival in cervical cancer, and two studies show benefits of bevacizumab on PFS in newly diagnosed glioblastoma as well.

Yoga improves fatigue and reduces inflammatory markers in breast cancer survivors

Yoga improves fatigue and reduces inflammatory markers in breast cancer survivors

Improvements in fatigue, IL-6, TNF-a, and IL-1B seen in a clinical trial that measured the effects of yoga practice in women survivors of breast cancer.

Mammography benefits women in their 40s

Mammography benefits women in their 40s

Breast cancer was diagnosed at earlier stages in women age 40 to 49 years who underwent routine screening mammography, and their tumors were less likely to require chemotherapy.

Marker may predict response to ipilimumab in advanced melanoma

Among patients with advanced melanoma, presence of higher levels of the protein VEGF in blood was associated with poor response to treatment with the immunotherapy ipilimumab.

Low recurrence breast cancer rates with negative margins

Low recurrence breast cancer rates with negative margins

Positive margins linked to two-fold increased risk of ipsilateral breast tumor recurrence, according to consensus guidelines.

New type of whole body scan could improve treatment of bone marrow cancer

A new type of magnetic resonance imaging (MRI) scan, known as diffusion-weighted MRI, could improve care for myeloma and reduce reliance on bone marrow biopsies.

Assessing HRQOL is valuable in small-cell lung cancer trials

Health-related quality of life assessment in randomized clinical trials in small cell lung cancer provides added information in studies where the treatment arms do not differ in terms of efficacy.

Positive long-term outcomes after adjuvant accelerated partial breast irradiation

Long-term outcomes of breast cancer patients receiving adjuvant accelerated partial breast irradiation after breast-conserving surgery show excellent tumor control with minimal late toxicity.

ACS outlines progress and challenges in childhood cancer

A new report from the American Cancer Society outlines the progress made and challenges that remain in fighting childhood cancer.

Brachytherapy raises future mastectomy risk compared with standard radiation in older women

When comparing treatments designed to enable long-term breast preservation for older women with invasive breast cancer, researchers found that those treated with brachytherapy were at higher risk for a later mastectomy.

Radiation before surgery more than doubles mesothelioma survival

Treating mesothelioma with radiation before surgery resulted in a 3-year survival rate that was more than double compared with that of treating with surgery first, according to new research.

Using methotrexate in children

Using methotrexate in children

Why do children with Down syndrome who are being treated for acute lymphocytic leukemia sometimes require oral leucovorin after intrathecal methotrexate administration?

Cellular senescence leads to acute promyelocytic leukemia cure

Targeted treatments for acute promyelocytic leukemia cause a cascade of molecular events that lead to cellular senescence and recovery. This action model could be activated in other types of cancers.

Running tops walking for breast cancer survival

Running tops walking for breast cancer survival

Researchers found a significantly reduced mortality risk for breast cancer survivors who run.

Survival improved with personalized tumor vaccines added to IL-2 for melanoma

Combining high-dose interleukin-2 and personalized vaccines to activate patients' immune systems improves survival of metastatic melanoma even more than IL-2 alone.

Biomarker may help predict melanoma survival

Biomarker may help predict melanoma survival

High pretreatment VEGF levels have been linked to lower survival after ipilimumab treatment.

Body image and sex life stay healthy for most women undergoing vulvar cancer surgery

A new study found that most women who undergo conservative surgery for vulvar cancer experience little to no long-term disruption to sexuality and body image.

Chemotherapy after radiation does not improve survival of rectal cancer

Long-term results of an EORTC trial show that 5- fluorouracil (FU)-based adjuvant chemotherapy after preoperative chemoradiotherapy for patients with cT3-resectable T4 M0 rectal cancer does not improve survival or disease-free survival.

Breast cancer in young women after treatment for Hodgkin lymphoma

Girls treated for Hodgkin's lymphoma during adolescence acquire a considerable risk of developing breast cancer.

Why exercise improves prostate cancer outcomes

Why exercise improves prostate cancer outcomes

Men who walked at a fast pace prior to a prostate cancer diagnosis had more regularly shaped blood vessels in their prostate tumors compared with men who walked slowly, providing a potential explanation for why exercise is linked to improved outcomes.

Yoga beneficial for breast cancer survivors

Yoga beneficial for breast cancer survivors

Twelve-week intervention linked to improved fatigue, vitality, lower levels of proinflammatory cytokines in participants.

Minorities and poor have more advanced thyroid cancers at diagnosis

Minority patients and those of lower socioeconomic status are far more likely to have advanced thyroid cancer at diagnosis than white patients and those in higher economic brackets.

Study shows pregnancy is possible for many female childhood cancer survivors

Study shows pregnancy is possible for many female childhood cancer survivors

Many women who are survivors of childhood cancer can become pregnant. This good news comes from the Childhood Cancer Survivor Study, in which nearly two-thirds of the women in the survivor group, initially unsuccessful at becoming pregnant, eventually conceived.

Children resilient when living with cancer

Children resilient when living with cancer

Although challenged, youth with cancer do not have higher rates of posttraumatic stress disorder.

Complications from cancer surgical care incur extremely high costs

Although complications from surgical care for cancer patients may seem infrequent, the costs associated with such outcomes are extremely high, according to researchers.

Early vulvar cancer treatment causes minimal body image impact

Early vulvar cancer treatment causes minimal body image impact

Little to no long-term disruption to sexuality or body image for women undergoing treatment for vulvar cancer found, according to a study published online.

Advanced radiation therapy better for head and neck cancer

Patients with head and neck cancer who are treated with an advanced form of radiation therapy may experience fewer side effects and be less likely to die from their disease than patients who receive standard radiation therapy.

Risk-reduction surgery for ovarian cancer improves survival

Preventive surgery improves survival for women who are at greater risk of developing ovarian cancer, and it may be helpful for women at risk of developing breast cancer due to genetics.

Protein linked to spread of breast cancer to brain

Protein linked to spread of breast cancer to brain

A protein has been identified that may be a key culprit when breast cancer metastasizes to the brain.

AACR: Exercise improves vessel shape in prostate cancer

AACR: Exercise improves vessel shape in prostate cancer

Brisk walking before prostate cancer diagnosis has been associated with more regularly-shaped blood vessels.

New biomarker for esophageal squamous cell carcinoma

A biomarker, adenosine deaminase acting on RNA-1 (ADAR1), has been discovered, and it has the potential to improve the diagnosis, prognosis, and treatment of esophageal squamous cell carcinoma.

New biomarkers linked to early diagnosis of breast cancer

New biomarkers linked to early diagnosis of breast cancer

Measuring the amount of certain protein fragments and microRNAs in a woman's blood and breast tissue might enable the early diagnosis of breast cancer or prediction of its metastasis.

One-fifth of advanced GI cancer hospitalizations avoidable

One-fifth of advanced GI cancer hospitalizations avoidable

A higher 90-day mortality was seen after avoidable versus non-avoidable hospitalizations.

Team approach makes patients happier and lowers costs for esophageal surgery

A new program designed to increase the overall satisfaction of patients undergoing esophageal surgery has resulted in lower patient costs and reduced times on both the operating table and in the hospital.

Nondrug interventions can effectively improve time to fall asleep and total sleep time

Nondrug interventions can effectively improve time to fall asleep and total sleep time

A new study demonstrates that nonpharmaceutical techniques can resolve sleep disturbance and insomnia in patients with cancer.

High-dose cytarabine improves outcomes in acute myeloid leukemia

High-dose cytarabine in induction treatment improves the outcomes of adult patients with acute myeloid leukemia (AML).

Pain drugs used during prostate gland removal linked to cancer outcome

The methods used to anesthetize patients with prostate cancer and control pain due to surgical resection of the prostate glands for adenocarcinoma may affect patients' long-term cancer outcomes, a study has found.

Fertility preservation neglected at most cancer centers

The leading National Cancer Institute-designated comprehensive cancer centers may not adequately help patients protect their fertility.

Intensity-modulated radiation increases HNC survival

Intensity-modulated radiation increases HNC survival

Findings among head and neck cancer patients treated with IMRT versus other types of radiation show significant improvements in cause-specific survival.

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