Overall survival was significantly prolonged in patients with advanced melanoma who were treated with nivolumab plus ipilimumab compared with either drug alone, according to results from the Checkmate 067 study.
Gemtuzumab ozogamicin (Mylotarg) was granted US FDA approval for the treatment of relapsed or refractory CD-33 positive AML in patients ages 2 years and older and newly diagnosed CD-33 positive AML in adult patients.
Lenalidomide reduced the relative risk of disease progression in a clinical trial of patients with chronic lymphocytic leukemia who did not achieve MRD negative disease state after first-line chemoimmunotherapy.
Comparison study shows significantly improved overall survival and progression-free survival in patients with advanced LPS treated with eribulin vs dacarbazine.
Oncological Safety and Cosmetic Outcomes in Oncoplastic Breast Conservation Surgery, a Review of the Best Level of Evidence Literature
[Breast Cancer: Targets and Therapy] This review examines oncological safety in oncoplastic breast conservation surgery, local recurrence and patient outcome, postoperative complications, and cosmetic outcomes.
Administering niraparib to patients with recurrent ovarian cancer after CR or PR to platinum-based chemotherapy may allow patients to continuously maintain QOL during treatment, reported researchers in presentation at ESMO 2017 Congress.
Reducing the initial dose of sorafenib was shown to have some benefits — such as reduced pill burden, lower costs, and decreased AE-related discontinuation rates — and OS was noninferior compared with the standard dose in patients with hepatocellular carcinoma.
The first interim analysis of the ENDEAVOR trial reported superiority of carfilzomib in some outcomes; however, data on overall survival were not available. This second interim analysis reports on overall survival with carfilzomib for patients with relapsed/refractory multiple myeloma.
There is an increased burden on caregivers to not only assist with IADLs but also to assess patient conditions and provide health care information.
Survival rate were worse for lower volume hospitals with higher quality scores, versus higher volume hospitals.
Novel intervention focuses on caregivers' beliefs, knowledge, and skills regarding home care for patients with cancer resulting in improved pain management and better overall care at the end of life.
Patients with high-risk chronic myelomonocytic leukemia (CMML), a MDS/myeloproliferative neoplasm, may experience prolonged overall survival and increased overall response rate from treatment with decitabine.
Resistance Training, Nutritional Interventions Prevent Muscle Loss During, After Radiotherapy for Head and Neck Cancer
Intervention with resistance training and nutritional supplements during and after radiation therapy is not only feasible, but also shown to prevent loss of muscle mass and improve quality of life in patients with head and neck cancer (HNC).
Contrary to some concerns, persons at high risk for lung cancer who undergo CT lung scans are more likely to attempt smoking cessation regardless of their test results compared with unscreened persons.
A London hospice facility's experiment with virtual reality offers patients at the end of life the chance to explore the world beyond their bed.
Overweight teens in Israel had about a 53 percent higher risk for colon cancer as adults, researchers found.
Use of antiperspirant or deodorant does not adversely affect potential for dermal toxicity or surface concentrations of aluminum in the axilla in women undergoing radiation therapy for breast cancer.
The Lung Cancer Prognostic Index (LCPI) provides additional relevant prognostic data for patients with NSCL and may lead to better outcomes.
Rare Case of Langerhans Cell Histiocytosis With Prior ITP Highlights Diagnostic Challenge for Clinicians
A rare case of Langerhans cell histiocytosis (LCH) in a patient with idiopathic thrombocytopenic purpura (ITP) highlights the difficulty in diagnosing LCH.
Skin Toxicity Evaluation in Patients Treated With Cetuximab for Metastatic Colorectal Cancer: A New Tool for More Accurate Comprehension of Quality of Life Impacts
This research aims to assess the correlation between quality of life (QoL) and severity of dermatological toxicity in patients with metastatic colorectal cancer.
Results of a recent study showed that neuropathic cancer pain (NCP) in patients with cancer was not only associated with a worsened quality of life but is also not adequately managed.
Two recent studies examined the benefits of using a 3D bioabsorbable marker to indicate the tumor bed in women with breast cancer who underwent breast conserving surgery (BCS).
An analysis of rates at certain milestones in clinical trials of treatments for mNSCLC suggests these rates reflect end point results for immunotherapies vs targeted and conventional therapies.
Lenvatinib Improves OS, PFS in Radioiodine-Refractory Differentiated Thyroid Cancer in All Older Patients
Results from a sub-analysis of the impact of age on the safety and efficacy of lenvatinib in patients with RR-DTC in the SELECT trial showed that lenvatinib significantly increased PFS.
Regular use of NSAIDs after diagnosis of colorectal cancer correlated with improved survival in survivors with KRAS wild-type tumors.
Women with breast cancer who received capecitabine after adjuvant epirubicin had better quality of life (QOL) compared with those who received CMF after adjuvant therapy.
Research on the effects of research demonstrated that oncology-related clinical trials provide measurable benefits in terms
Survivorship care plans can ensure that cancer survivors know their cancer and treatment history, and are equipped to maintain proper follow-up care.
Lifestyle changes that promote proper weight management, increased exercise, and a healthy diet have the potential to improve survivors' health and well-being.
Survivorship care plan successfully improves the overall survivorship care of older cancer survivors using lay navigators.
Older cancer survivors typically have higher severity of disease and pre-existing conditions, which makes their cancer treatment additionally challenging. The Patient Care Connect Program was created to help address these issues.
Risk of nonadherence was lower for survivors reporting a usual source of care than those without
More public tolerance for health care inequalities has been observed in the United States than other countries.
Study finds a correlation between various measures of neurocognitive function and health utility scores.
Addition of abiraterone to androgen deprivation therapy for patients with hormone-naïve advanced prostate cancer may be a new standard of care.
Study compared FOLFOXIRI/bevacizumab and FOLFOX/bevacizumab in patients with metastatic colorectal cancer.
Study implicates higher doses of cardiac radiotherapy and exposure to high-dose anthracyclines.
Active coping is associated with a better quality of life and a decrease in depression symptoms, study finds.
A decline in the incidence of serious chronic diseases in survivors of childhood cancer may be linked to changes in treatment protocols.
'Conquer Fear' decreased fear among survivors of breast and colorectal cancer and melanoma compared with relaxation techniques.
Change in FACT-O TOI score from baseline to 12 months did not differ significantly between maintenance olaparib and placebo.
Patients with stage III colon cancer who follow the ACS guidelines for a healthy lifestyle after adjuvant chemotherapy had longer disease-free survival and overall survival.
Trends in caregiver involvement in home-based patient care are introducing new avenues for symptom management and improved health-related quality of life for patients undergoing chemotherapy for advanced breast cancer.
Axalimogene filolisbac, an intravenous vaccine currently in clinical trials, could prevent often-fatal cervical cancer relapse.
High Levels of Negative Emotions in Breast Cancer Survivors Motivates Exercise, Increases Cortisol Levels
Negative emotions were shown to motivate breast cancer survivors to engage in moderate-to-vigorous exercise, and can increase their daytime levels of cortisol.
Complete surgical metastasectomy correlated with increased survival in patients with metastatic renal cell carcinoma (mRCC) compared with incomplete surgical metastasectomy.
Disease-specific survivorship care plans (SCPs) for head and neck cancer support a successful transition to a healthy lifestyle after curative intent therapy of larynx and oral cavity/pharynx cancer.
A literature review noted improvements in quality of life after patients were coached and educated following radiotherapy for HPV-associated oropharyngeal cancers.
Including beans and whole grains such as rice in the diet is associated with a reduced burden of CRC in survivors.
Patients with myeloma that underwent transplantation in addition to RVD had significantly longer median progression-free survival compared to the group that received RVD alone.
A significantly higher 5-year survival rate was seen in a small subset of patients with NSCLC treated with nivolumab.
Program provides physical, nutritional, and psychological guidance
Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk
Whole genome sequencing of more than 3000 survivors of childhood cancers demonstrates the value of genetic testing for potential second cancers in this population.
Physical activity is proven to improve both physical and mental effects of cancer diagnosis and treatment, even if the activity needs to be modified to fit the patient's current abilities.
Continuing immunotherapy after disease progression extends survival for some patients with head and neck cancer.
The joint report states that overall cancer rates have decreased for men, women, and children in all major race and ethnic groups. However, progress has been limited for some cancers.
Although median survival is longer for Hispanic and black patients compared with white patients, health-related QoL is poor for minority patients.
Quality of life was maintained in patients with ovarian cancer who received chemotherapy with concurrent cediranib then cediranib alone as maintenance therapy.
Arm anthropometry is a better tool for assessing nutritional status of survivors of childhood cancer.
QoL after radical prostatectomy, EBRT, or brachytherapy vs active surveillance for prostate cancer are similar.
Cancer treatment during childbearing years increased risk of preterm birth and delivering low birth weight babies.
Checkpoint inhibitor pembrolizumab appears well-tolerated with antitumor activity in patients with malignant pleural mesothelioma.
AYAs continue to report lower social functioning scores than their peers 2 years after diagnosis.
Cancer deaths within 1 month of diagnosis occur most often in patients younger than 1 years, especially among Blacks and Hispanics.
Increased risks among live births for adolescent and young adult cancer survivors
A significant reduction in use of radiation therapy to treat childhood cancers improved survival, reduced second cancers in survivors.
The efficacy of imatinib for CML treatment persisted over time and long-term administration was not associated with unacceptable cumulative effects.
Deciding not to intervene for small, incidentally identified thyroid cancer may cause patients to experience anxiety and feelings of isolation.
Living in a high-poverty region is associated with lower access to obesity-related self-care resources.
Nonadherence to NCCN guideline treatment recommendations was strongly associated with decreased survival from early-stage cervical cancer.
A phase 3 analysis of SWOG Intergroup Trial S0033 reveals that imatinib significantly extends survival in patients with GIST.
Despite the known benefits of physical activity for breast cancer survivors, a large proportion of this population continues to be physically inactive after treatment.
Simply walking for 30 minutes 3 times a week has significant impact on symptom severity and ability to cope, as well as quality of life, for patients with advanced cancer.
ASCO endorses ACS head and neck survivorship care guideline, which supports health promotion, especially regarding tobacco cessation and dental care.
Individuals with serious carcinoma of the ovary or peritoneum experienced improved progression-free survival after hormone maintenance therapy.
The researchers hope the results will lead to an increase in clinicians offering trials to their patients and an increase in women volunteering to participate in trials.
The addition of pravastatin to first-line chemotherapy did not improve overall survival or progression-free survival in patients with small-cell lung cancer.
Internet-based cognitive behavioral therapy has positive effects on sexual functioning in breast cancer survivors experiencing sexual dysfunction.
Painter and tattoo artist David Allen has used his skills to transform breasts scarred by surgical reconstruction into works of art.
The site of cancer care may partially explain survival differences between children and AYAs with ALL.
Patients with hormone receptor-positive, HER2-negative, axillary lymph node-negative breast cancer who have a recurrence score of 11 to 25 may not benefit from chemotherapy.
Outcomes improved with short-course radiation and delay to surgery of 4 to 8 weeks.
E-cigarettes and replacement nicotine therapy deposit fewer harmful chemicals in the body that smoking.
Adjuvant trastuzumab following chemotherapy significantly improves long-term disease-free survival in women with HER2-positive early breast cancer, according to study data.
Adding chemotherapy with fluorouracil and mitomycin to radiotherapy improves locoregional control.
A higher overall number of genetic alterations in cell-free circulating tumor DNA (ctDNA) were associated with worse treatment outcomes.
Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.
Survivors of testicular cancer are more likely to develop metabolic syndrome after platinum-based chemotherapy.
Using statistical models, predictions were made for death rates from melanoma in 3 three countries and based on availability of a treatment.
Investigators determined the impact of socioeconomic status on disease status at presentation and survival among patients with head and neck squamous cell carcinoma.
In this study, the impact of cholesterol-lowering medications on breast cancer recurrence in women receiving adjuvant endocrine therapy was investigated.
The impact of oral squamous cell carcinoma (OSCC) diagnosis and treatment on sexual behavior and relationship stress with respect to HPV status was evaluated in this study. Participants included patients with HPV-positive and HPV-negative disease, as well as partners.
Survivors of childhood cancer who received certain neurotoxic therapies are less likely to have had sexual intercourse or to be in an intimate relationship, researchers found.
Investigators from the Netherlands present their research findings on survival in women with early stage breast cancer who underwent breast-conserving therapy vs mastectomy at the 2017 European Cancer Congress.
Use of Adjuvant gemcitabine plus capecitabine for patients with pancreatic cancer who have undergone tumor resection resulted in a modest increase short-term survival.
Investigators studied the effects of adding antiandrogen therapy to radiotherapy on cancer control and overall survival in men with prostate cancer recurrence after radical prostatectomy.
Cancer survivors who reported chronic neuropathic pain 5 years after diagnosis were approximately 50% less likely to retain their jobs than those without chronic neuropathic pain.
Lifelong soy consumption improves tamoxifen response in women with breast cancer; however, adding soy to diet after initiating tamoxifen therapy may not provide the same benefits.
There are a growing number of NSCLC patients with advanced disease who are opting to forgo treatment despite the fact that receiving standard of care treatment leads to a higher OS.
Three specific genetic alterations may help identify pediatric patients with AMKL at high risk who may benefit from allogeneic stem cell transplants.
- Neurotoxicity After CAR T-cell Therapy May Be Associated With Endothelial Activation
- Navigation Programs Most Effective in Increasing Follow-up Colonoscopy
- New Class of Clinical Trial Enhances Research on Cancer Care Delivery
- Nivolumab Provides Better Long-Term Efficacy Compared With Docetaxel in NSCLC
- Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer
- Anticancer Properties of The Probiotic Kefir: A Review
- Navigating the Transition From Treatment to Breast Cancer Survivor
- Combining Radiation, Immunotherapy: An Emerging Challenge for Oncology Nursing
- Naldemedine Effective for Opioid-Induced Constipation in Cancer Pain
- Disruptions to Circadian Rhythm Linked to Prostate Cancer Surgery Regret
- Case Report of a KIT-mutated Melanoma Patient With an Excellent Response to Apatinib and Temozolomide Combination Therapy
- Novel Predictive Model More Effectively Identifies Risk for Lung Cancer
- Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP
- Overall Survival Increase for Melanoma Brain Metastases
- Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer
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