Tumor cells prep lymphatic cells to encourage breast cancer cells to spread

Breast cancer cells can lay the groundwork for their own metastasis throughout the body by coaxing cells within lymphatic vessels to send out tumor-welcoming signals.

Protein deletion predicts length of progression free survival (PFS) in patients with non-small cell lung cancer (NSCLC)

Deletion of the Bcl-2-like protein 11 (BIM) in advanced non-small cell lung cancer has been associated with shorter progression free survival (PFS).

Risk of premature menopause after Hodgkin lymphoma treatment is mapped

Women treated for Hodgkin lymphoma will be able to better understand their risks of future infertility after researchers estimated their risk of premature menopause with different treatments.

Patient and tumor characteristics in melanoma examined for clues to aggressive form of disease

Researchers in Australia examined patient and tumor characteristics of melanomas for higher mitotic rates (a marker of tumor cell growth) in an effort to increase early detection.

For black men with prostate cancer, watchful waiting may be unwise

For black men with prostate cancer, watchful waiting may be unwise

For men with early-stage prostate cancer, watching waiting is not always the best course of action, especially for black patients.

Irinotecan promising in some patients with stage III colon cancer

A subset of patients with stage III colon cancer had improved survival rates when treated with irinotecan-based therapy, according to recent research.

Weekend hospitalization linked to longer stays for pediatric patients with leukemia

Weekend hospital admission for pediatric patients with newly diagnosed leukemia is associated with a longer length of stay, slightly longer wait to start chemotherapy, and higher risk for respiratory failure.

Soy may be detrimental for women with breast cancer

Soy may be detrimental for women with breast cancer

Study raises questions about the effect of soy's estrogen-like properties.

Biomarker highly promising for predicting breast cancer outcomes

A protein named p66ShcA shows promise as a biomarker to identify breast cancers with poor prognoses, according to new research.

Opioid-related deaths are almost 25% lower in states with medical marijuana laws

Rates of death resulting from opioid analgesic overdoses are lower in states that allow medical use of marijuana compared with states without such laws.

Surgery associated with better survival for patients with advanced laryngeal cancer

Patients with advanced laryngeal cancer appear to have better survival if they are treated with surgery than with nonsurgical chemoradiation.

Natural killer cells battle pediatric leukemia

Natural killer cells battle pediatric leukemia

A select team of immune-system cells from patients with leukemia can be multiplied in the laboratory, creating a horde of natural killer cells that can be used to target and destroy the cancer cells.

Factors associated with late hospice admission for cancer patients identified

Factors associated with late hospice admission for cancer patients identified

For patients with cancer, late admission more likely for younger patients, married men, hematologic malignancies.

Promising results from trial for late-stage peritoneal cancers

A drug originally used to treat ovarian cancer has shown promising results in patients with advanced peritoneal cancers during a phase I clinical trial.

New analyses of epigenetics reveal tumor weaknesses

Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer.

Major breakthrough in understanding acute lymphoblastic leukemia

Major breakthrough in understanding acute lymphoblastic leukemia

By analyzing the DNA sequence of patients at different stages of leukemia, researchers have discovered mutations in genes that lead to childhood leukemia of the acute lymphoblastic type, the most common childhood cancer.

Less radical procedures control kidney cancer similarly to surgery

Needle-guided tumor destruction procedures offer near equivalent lengths of cancer control when compared with surgery for patients with small kidney cancer tumors.

Now what? Aiding patients in planning for cancer survival

Now what? Aiding patients in planning for cancer survival

The transition to a primary care provider after completing cancer treatment should begin with a plan that documents treatments and follow-up care.

Gene likely to promote childhood cancers pinpointed

Researchers have identified a gene that contributes to the development of several childhood cancers, research that could lead to new strategies for targeting certain childhood cancers at a molecular level.

Postmenopausal breast cancer risk drops off after starting regular physical activity

Postmenopausal women who in the past 4 years had undertaken regular physical activity equivalent to at least 4 hours of walking per week had a lower risk for invasive breast cancer compared with women who exercised less

Chemoprotective effects of coffee

Chemoprotective effects of coffee

Diet and nutrition are significant factors in preventing hepatic diseases progressing to hepatocellular carcinoma, and coffee is high on the list of good foods.

Lung cancer rates declining but vary by subtype, sex, race/ethnicity, and age

A new analysis confirms that US lung cancer rates are declining overall, but it also uncovers previously unrecognized trends related to cancer subtype, sex, race/ethnicity, and age.

Expressive writing improves health outcomes for breast cancer survivors

Writing down fears, emotions, and the benefits of a cancer diagnosis may improve health outcomes for Asian American survivors of breast cancer, according to a new study. The research investigated methods of reducing the psychological burden among minority patients, particularly among breast cancer survivors.

Molecular panel increases likelihood that initial surgery for thyroid cancer is corrective

Routine use of a molecular testing panel greatly decreased the need for an initial lobectomy to confirm diagnosis in patients with thyroid nodules and cancer, reported researchers. The test improved the chances of patients undergoing the correct initial surgery by 30%.

Childhood cancer survivors do not eat healthier than their peers

Childhood cancer survivors do not eat healthier than their peers

Having survived cancer as a child does not necessarily have a ripple effect.

Single-fraction radiation therapy (SFRT) as effective as multiple-fraction (MFRT) for palliating bone metastases

Standardizing prescribing practices for single-fraction radiation therapy (SFRT) for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a new study.

Protein is predictive of treatment that makes radiotherapy for bladder cancer more effective

Scientists have identified a protein that could help doctors decide which patients with bladder cancer would benefit from a treatment that makes radiotherapy more effective, according to a new study.

Drug target identified for common childhood blood cancer

In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers report that they have identified a possible new drug target for treating the disease.

Computer tomography (CT) lung screening benefits far outweigh patient anxiety

Anxiety regarding inconclusive cancer screening test results among some patients is real and is only natural. However, as evidenced by a recent study, the incidence and effects of anxiety associated with false positive or other results of CT lung cancer screening exams are far less than claimed by some in the medical community.

Unhealthy habits double metabolic syndrome risk for childhood cancer survivors

By failing to follow a heart-healthy lifestyle, 73% of adult survivors of childhood cancer more than doubled their risk of developing metabolic syndrome and related health problems, according to a new study.

Lasting drop in prostate cancer mortality with prostate-specific antigen (PSA)

Lasting drop in prostate cancer mortality with prostate-specific antigen (PSA)

Prostate-specific antigen (PSA) screening is associated with a lasting reduction in prostate cancer mortality, according to a study published online.

Genomic analysis of prostate cancer suggests best plan after surgery

Genomic analysis of prostate cancer suggests best plan after surgery

A genomic tool can help doctors and patients make a more informed decision on the need for radiation therapy after surgery for prostate cancer.

Survival better with surgical resection than with endoscopic resection for early esophageal cancer

A study sheds new light on the risks associated with the growing popularity of endoscopic resection in the treatment of localized, early stage esophageal cancer. Researchers found that the more traditional surgical resection, while more invasive, provided significantly better outcomes for patients than endoscopic resection.

Saltier IV reduces complications from Whipple surgery for pancreatic cancer

Adequate hydration via a saline drip is essential during surgery, but recent reports suggest that getting the balance of salt and water just right could have an important impact on patient recovery.

Recent use of some birth control pills may increase breast cancer risk

Recent use of some birth control pills may increase breast cancer risk

Women who recently used birth control pills containing high-dose estrogen and a few other formulations had an increased risk for breast cancer, whereas women using some other formulations did not, according to recent data.

Surgical treatment for metastatic melanoma of the liver increases overall survival

Surgical resection markedly improves survival among patients with metastatic melanoma whose disease is isolated to a few areas in the liver, according to new study findings.

Even after cancer diagnosis, 1 in 10 survivors continues to smoke

Even after cancer diagnosis, 1 in 10 survivors continues to smoke

A new study published in the journal Cancer Epidemiology, Biomarkers, & Prevention found that nearly 1 in 10 cancer survivors continued smoking despite their cancer diagnosis

Robot-assisted surgery for prostate cancer controls disease for 10 years

Robot-assisted surgery to remove cancerous prostate glands is effective in controlling the disease for 10 years, according to a new study.

Healthy lifestyle reduces metabolic syndrome risk for cancer survivors

Healthy lifestyle reduces metabolic syndrome risk for cancer survivors

Reduced risk of metabolic syndrome (MetS) has been observed in male and female childhood cancer survivors who adhere to WCRF/AICR guidelines.

Shingles vaccine found to be safe and effective after chemotherapy

Shingles vaccine found to be safe and effective after chemotherapy

The herpes zoster vaccine continues to be effective in protecting older adults against shingles, even after they undergo chemotherapy, according to a recent study.

Rehabilitation benefits advanced cancer patients

Patients with advanced cancer can benefit from a rehabilitation program combining exercise, nutritional counselling, and symptom control, according to an evidence review.

Navigators can help guide patients with breast cancer through care

Navigators can help guide patients with breast cancer through care

A team of researchers from Boston University School of Medicine sought to determine the impact of patient navigators on the care of low-income and African-American women with breast cancer.

Electroacupuncture improves quality of life for breast cancer patients using AIs

Electroacupuncture improves quality of life for breast cancer patients using AIs

Use of electroacupuncture produces significant improvements in fatigue, anxiety, and depression in as little as 8 weeks for patients with early stage breast cancer patients experiencing joint pain related to the use of AIs to treat breast cancer.

Overall survival in advanced NSCLC increased with less toxic chemotherapy

A 10-year study shows that increased availability of better systemic chemotherapies and targeted therapies for patients with advanced non-small cell lung cancer coincides with increased usage of these therapies.

Repeat colonoscopies not always beneficial for some patients

Repeat colonoscopies not always beneficial for some patients

Little benefit seen for repeat colonoscopy within 10 years in patients with no polyps on initial exam.

Research team makes cancer glow to improve surgical outcomes

Research team makes cancer glow to improve surgical outcomes

Surgical resection is the most effective method for a cancer cure; however, the procedure may not remove the entire tumor, leading to local recurrence. Researchers at the University of Pennsylvania have established a new strategy in which near-infrared (NIR) imaging is used to help visualize the entire tumor.

Survival equivalent with cetuximab or bevacizumab in metastatic colorectal cancer

For patients with KRAS wild-type untreated colorectal cancer, adding cetuximab or bevacizumab to combination chemotherapy offers equivalent survival.

Study compares treatment risks for early esophageal cancer

Study compares treatment risks for early esophageal cancer

A new study sheds new light on the risks associated with the growing popularity of endoscopic resection in the treatment of localized, early-stage esophageal cancer.

Fewer cardiac scans in low-risk childhood cancer survivors can safely reduce costs

A less frequent screening schedule would both reduce health care charges and still protect low-risk childhood cancer survivors from heart ailments caused by drug therapy, according to recently published findings.

Everolimus does not improve overall survival of advanced liver cancer

Despite strong preclinical data, the drug everolimus failed to improve overall survival in patients with advanced liver cancer, compared to placebo, according to a study.

A review of radiotherapy-induced hypopituitarism

A review of radiotherapy-induced hypopituitarism

Some patients undergoing radiotherapy for cancers of the head, neck, and brain are at risk for endocrinopathies. This article reviews the risks, detection, and management of radiotherapy-induced hypopituitarism.

Lifestyle choices may lower metabolic syndrome risk of for cancer survivors

Lifestyle choices may lower metabolic syndrome risk of for cancer survivors

A study conducted by researchers based at the St. Jude Children's Research Hospital has determined that healthy lifestyle choices can help cancer survivors avoid the metabolic syndrome.

Colorectal cancer survival associated with higher vitamin D levels

Colorectal cancer survival associated with higher vitamin D levels

Colorectal cancer patients with high levels of vitamin D in their blood are more likely to survive the disease, a study shows.

Lack of Trust in One's Doctor Affects Health of Emotionally Vulnerable Cancer Patients

Lack of Trust in One's Doctor Affects Health of Emotionally Vulnerable Cancer Patients

Patients' relationship with their doctor and their attachment style may affect their physical and mental well-being, especially during vulnerable times such after a cancer diagnosis, according to a new study.

Exercise And Nutrition Counseling Plus Palliative Care Improves Quality Of Life For Patients With Cancer

Exercise And Nutrition Counseling Plus Palliative Care Improves Quality Of Life For Patients With Cancer

A team of researchers in Canada concludes that combining exercise, nutritional counseling, and symptom control to palliative care from diagnosis helps to improve the quality of life for patients with cancer.

Noninvasive advanced image analysis may improve care for lung cancer patients

Lung cancer patients could receive more precise treatment, and their progress could be better tracked by using a new high-tech method of non-invasive medical imaging analysis, according to a new study.

Rates of observation as prostate cancer management vary

Rates of observation as prostate cancer management vary

Rates of observation as management for low-risk prostate cancer vary widely, and primary ADT is not tied to better survival for men with localized prostate cancer.

Robot-assisted surgery effective in controlling prostate cancer for 10 years

Robot-assisted surgery effective in controlling prostate cancer for 10 years

Results of a new study show that robot-assisted surgery to remove cancerous prostate glands is effective in controlling the disease for 10 years.

Managing follicular lymphoma

Managing follicular lymphoma

Changes in how follicular lymphoma is managed have led to substantial improvement in prognosis and over all survival for patients with the disease.

New drug active against most aggressive type of lung cancer

Scientists have shown that a new drug could prove useful in treating small cell lung cancer, the most aggressive form of lung cancer.

Depressed men with prostate cancer have worse outcomes

Depressed men with prostate cancer have worse outcomes

Depressed men with a diagnosis of intermediate- or high-risk prostate cancer have worse overall outcomes.

Doctors steer prostate cancer treatment choices

Doctors steer prostate cancer treatment choices

Physicians who diagnosed low-risk prostate cancer had more influence over the decision to enter active surveillance than did the disease characteristics, according to a case review.

Radiation-induced toxicity risk in prostate cancer predicted by variations in key gene

Key genetic variants may affect how cancer patients respond to radiation treatments, according to a new study.

Study explores reasons for significant variations in blood cancer survival across Europe

Study explores reasons for significant variations in blood cancer survival across Europe

The EUROCARE study, the largest population-based study of survival in European blood cancer patients to date, analyzed data from 30 cancer registries, involving all patients with cancer diagnoses in 20 European countries.

DII may be a potential determinant of hospitalization duration among surgically treated patients with colorectal cancer

DII may be a potential determinant of hospitalization duration among surgically treated patients with colorectal cancer

The dietary inflammatory index may be used as a potential predictor of length of hospitalization among patients undergoing surgical treatment of colorectal cancer, according to a team of researchers at Jagiellonian University Medical College, in Krakow, Poland.

Latest findings give optimistic picture of breast cancer survival odds

Latest findings give optimistic picture of breast cancer survival odds

New findings from Fox Chase Cancer Center paint a relatively optimistic picture of women's chances of surviving a subset of breast cancers that have spread to the chest wall or skin.

New test predicts survival in patients with leukemia

New test predicts survival in patients with leukemia

Scientists have developed a test which accurately predicts the prognosis for patients with the most common form of leukemia.

Nanoliposome formulation improves drug delivery and survival in metastatic pancreatic cancer

The addition of MM-398, a novel nanoliposome formulation of irinotecan, to standard treatment improves survival for metastatic pancreatic cancer patients who have already received gemcitabine.

Insurer's study finds cost-effective way to treat cancer

Insurer's study finds cost-effective way to treat cancer

A new model for paying oncologists reduced cancer care costs by 34% without changing how well patients fared after treatment, according to a study conducted by UnitedHealthcare.

Genetics could factor into racial disparity in colon cancer

Genetics could factor into racial disparity in colon cancer

African-Americans are half as likely to have the genetic marker associated with improved survival.

Telephone call is effective support when breast cancer treatment includes weight loss

A series of simple telephone calls can make a profound difference in helping women with breast cancer to meet their treatment goals for weight loss.

Combination treatment improves recurrence and survival in ovarian cancer

A new combination of medications for treatment of recurrent ovarian cancer showed improved response rates, increased the rate of tumor shrinkage, and prolonged the time until cancers recurred

Benefits of trastuzumab outweigh the risk of harm in advanced breast cancer

A new systematic review shows that treatment with the breast cancer drug trastuzumab is associated with prolonged survival in women with advanced breast cancer, but the risk of developing heart problems also increases.

Study Results Demonstrate A New Prostate Cancer Treatment

Study Results Demonstrate A New Prostate Cancer Treatment

A new study is suggesting a different approach to treating prostate cancer. Researchers at Comprehensive Cancer Centers of Nevada conducted a study in which 790 men with advanced stages of prostate cancer received early chemotherapy.

Bisphenol A Triggers Changes in Rats That May Lead to Breast Cancer

Bisphenol A Triggers Changes in Rats That May Lead to Breast Cancer

New research presents another cause for concern in regard to the chemical bisphenol A (BPA). The study is the first to examine what impact BPA has on the DNA of mammary glands as they age.

Risk of hospitalization increased for childhood cancer survivors, even years after treatment

Survivors of childhood cancers were hospitalized more often and had longer hospital admissions many years after cancer treatment was completed, compared with the general population.

Early initiation of palliative care support improves caregiver quality of life and patient survival

Early initiation of palliative care support improves caregiver quality of life and patient survival

The earlier a specific phone-based, palliative care support program can be introduced to caregivers, the better they will be able to cope with the caregiving experience, according to research conducted by University of Alabama at Birmingham School of Nursing investigators.

Answering the unanswerable

Answering the unanswerable

Sometimes the best answer to a patient's question is quiet support. Can you recognize when no words are needed?

LDCT screening for lung cancer does not induce long-term anxiety or distress

A review of studies that evaluated patient-centered outcomes of LDCT screening for lung cancer found that overall quality of life is not significantly impacted in persons who undergo the screening procedure.

Study demonstrates improved diagnosis and outcomes with LDCT

A study using a 5-year LDCT screening protocol showed good adherence and patient survival outcomes in persons at high risk of developing lung cancer.

'Financial Toxicity' tool created to assist cancer patients

'Financial Toxicity' tool created to assist cancer patients

A four-step process involving 155 patients with cancer was used to develop patient-reported outcome measure.

A few circulating tumor cells can indicate metastasis risk

A simple, noninvasive blood test matched with state-of-the-art molecular imaging of individual cells could help oncologists understand their patients' chances of survival.

Molecular breast imaging protocol unmasks more cancer in advanced cases

Patients with advanced breast cancer that may have spread to their lymph nodes could benefit from a more robust dose of a molecular imaging agent when undergoing lymphoscintigraphy.

Limiting carbs may reduce breast cancer recurrence in some women

Limiting carbs may reduce breast cancer recurrence in some women

Reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the insulin-like growth factor-1 (IGF1) receptor, according to a new study.

Diets high in dairy may up colon cancer survival

Diets high in dairy may up colon cancer survival

A diet rich in dairy products may slightly extend the lives of people diagnosed with colon cancer, a new study suggests.

Advanced heart imaging raises lifetime cancer risk of children

Children who undergo repeated complex imaging tests that deliver higher doses of radiation may have a slightly increased lifetime risk of cancer, according to new research.

Study Compares Outcomes for Treatments of Uncommon Eye Cancer

Study Compares Outcomes for Treatments of Uncommon Eye Cancer

Treatment with selumetinib resulted in improved progression-free survival time and tumor response rate compared with chemotherapy, but no improvement was seen in overall survival. Furthermore, the modest improvement in clinical outcomes was accompanied by a high rate of adverse effects.

National Childhood Cancer Strategies Are Needed for Low- and Middle-Income Countries

National Childhood Cancer Strategies Are Needed for Low- and Middle-Income Countries

Cancer represents the leading cause of nonaccidental death among children in an increasing number of middle-income countries. Meaningful declines in global childhood cancer mortality will require moving toward the establishment of national childhood cancer strategies.

Restoring gene function reverses cancer in common childhood leukemia

Restoring gene function reverses cancer in common childhood leukemia

Researchers in Melbourne, Australia, have shown that switching off a gene called Pax5 could cause a type of leukemia, and restoring its function could cure the disease.

Breast cancer surgery trends in Canada similar to that in United States

Breast cancer surgery trends in Canada similar to that in United States

To better understand breast cancer surgery trends in Canada, researchers reviewed data from the Canadian Institute for Health (CHI) on 57,840 women who underwent breast cancer surgery between 2007 and 2010.

Specialized apps extend the reach of community

Specialized apps extend the reach of community

In Alabama, smartphone technology brings regional resources to patients with cancer; in New Jersey, it motivates adolescent survivors to exercise.

Hospitalization rate greater for childhood cancer survivors

Hospitalization rate greater for childhood cancer survivors

A higher hospital admission rate is seen for childhood survivors, with highest rates for survivors of neuroblastoma and bone tumors.

Gene mutation lowers breast cancer survival

Gene mutation lowers breast cancer survival

Women with a specific gene mutation have a higher risk of dying from a type of breast cancer, according to a study that raised prospects of targeted drugs.

Growing pains noted in survey on moving toward quality patient-centered care

In order to meet new cancer program accreditation standards, institutions have placed new focus on patient navigation, psychosocial distress screening, and survivorship care plans.

Hyperfractionated radiotherapy improves overall survival in patients with head and neck cancer

Hyperfractionated radiotherapy improves overall survival in patients with head and neck cancer

A multi-institutional, randomized phase III trial of fractionation in locally advanced head and neck cancer demonstrated improved local-regional control and improved overall survival with no increase in late toxicity with hyperfractionated radiation therapy.

Patient risk information improves mammogram interpretation

Patient risk information improves mammogram interpretation

A research group's findings demonstrate a role for risk profiling in the interpretation of mammograms. The new approach takes into account a woman's health risk profile, which may reduce both the number of missed cancers and false positives.

Tobacco companies to introduce e-cigarettes

Tobacco companies to introduce e-cigarettes

Big tobacco companies are jumping into the rapidly expanding and lucrative e-cigarette market.

Patient navigation: Is it a process or person?

Patient navigation: Is it a process or person?

Optimum, risk-based survivorship health care is a provision of lifelong care that integrates cancer and survivorship experiences in survivors' overall health care needs.

Lowering carb intake could help reduce breast cancer risk

Lowering carb intake could help reduce breast cancer risk

Concerned about the associations between obesity, diabetes, and cancer risk, researchers examined the links between carbohydrate intake and breast cancer risk.

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