Surgery plus radiation boosts survival in metastatic gastric cancer

Share this article:

Although persons with metastatic gastric cancer have poor survival, a recent study published by the journal Cancer indicated that those who have both surgery and radiation live longer than do those who undergo just one or neither of those treatments.

Ravi Shridhar, MD, PhD, of the radiation oncology department at H. Lee Moffitt Cancer Center & Research Institute in Tampa, Florida, and colleagues identified 5,072 patients with stage IV gastric cancer from the Surveillance, Epidemiology, and End Results (SEER) database. Analyzing data from 2004 to 2008, the investigators found surgery and/or radiation to be associated with increased survival, with the greatest benefits seen in persons undergoing both treatments.

Median survival and 2-year survival were as follows:

  • 16 months and 31.7%, respectively, among patients who underwent both surgery and radiation therapy
  • 10 months and 18.2%, respectively, among patients who underwent surgery only
  • 8 months and 8.9%, respectively, among patients who underwent radiation only
  • 7 months and 8.2%, respectively, among patients who underwent neither surgery nor radiation.

“This was the first SEER database study to suggest a survival benefit for patients undergoing both surgery and radiation in the management of metastatic gastric cancer,” noted Shridhar in a statement from Moffitt. “Even in the metastatic setting, patients undergoing surgery had better survival if they received radiation therapy and had more than 15 lymph nodes removed.”

Nevertheless, noted the authors, these findings should not be used to make general recommendations about surgery and radiation for patients with metastatic gastric cancer. Rather, the information should be used to form the basis for conducting clinical trials to assess the roles of surgery and radiation in patients who have responded to systemic chemotherapy, the current standard of care for metastatic gastric cancer.

“If the patient has not responded to chemotherapy, surgery and radiation will likely hold no benefit,” explained Shridhar in the Moffitt statement.

Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Web Exclusives

Leukemia drug dasatinib promising for skin, breast, and other cancers

The leukemia drug dasatinib shows promise as a treatment for skin, breast, and several other cancers, according to new research.

Calcium isotope analysis predicts myeloma progression

Researchers believe that a staple of Earth science research can be used in biomedical settings to predict the course of disease.

Biomarker for aggressive, basal-like breast cancer identified

A biomarker strongly linked to basal-like breast cancer has been identified.