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SUPPRELIN LA
Pituitary disorders
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Drug Name:

SUPPRELIN LA Rx

Generic Name and Formulations:
Histrelin acetate 50mg; SC implant.

Company:
Endo Pharmaceuticals

Therapeutic Use:

Indications for SUPPRELIN LA:

Treatment of central precocious puberty.

Adult:

Not applicable.

Children:

<2yrs: not recommended. ≥2yrs: Insert 1 implant SC in the inner aspect of the upper arm. Remove after 12 months; may replace. Consider discontinuing at appropriate time point for onset of puberty.

Contraindications:

Pregnancy (Cat.X).

Warnings/Precautions:

Use aseptic technique. Monitor for psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Monitor LH, FSH, and estradiol or testosterone at 1 month post implantation, then every 6 months thereafter. Assess height and bone age every 6–12 months.

Interactions:

May interfere with pituitary gonadotropic and gonadal function tests. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs).

Pharmacological Class:

GnRH agonist.

Adverse Reactions:

Implant site reactions (eg, bruising, pain, soreness, erythema, swelling), initial worsening of signs/symptoms.

How Supplied:

Kit—1 (w. implant and insertion tool)

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