Stem Cells

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

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Cancer stem cells that drive tumor growth were halved by MEDI-551, an experimental antibody treatment for multiple myeloma, according to results of a small preliminary clinical trial.

Research Results Bring Science One Step Closer to Creating Blood Stem Cells in the Laboratory

Research Results Bring Science One Step Closer to Creating Blood Stem Cells in the Laboratory

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New research has shed light on how the blood is produced in the body, and this work, done in mice, moves science a step closer to manipulation of blood stem cell creation. This could reduce the need for bone marrow transplants, such as those needed by patients with cancer.

HPV Status Affects Conversion of Cancer Cells to Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

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Radiation treatment can transform head and neck cancer cells that survive the treatment into cancer stem cells that are resistant to radiation therapy, and this transformation is more prevalent when the cancer is HPV-negative.

Bone Marrow vs PBSCs: Preference of Stem Cell Source for Bone Marrow Failure Varies Worldwide

Bone Marrow vs PBSCs: Preference of Stem Cell Source for Bone Marrow Failure Varies Worldwide

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Sources of stem cells used to treat bone marrow failure vary around the world, with bone marrow harvest more commonly used in areas with more resources. PBSCs are more commonly used in regions with limited resources.

Glioblastoma Stem Cells as a New Therapeutic Target for Glioblastoma

Glioblastoma Stem Cells as a New Therapeutic Target for Glioblastoma

[Clinical Medicine Insights: Oncology] This research examines hypoxia as a new therapeutic target for primary and secondary glioblastomas.

Sleep Deprivation Affects Stem Cells and Reduces Transplant Efficiency

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A sleep deficit of just 4 hours affects the ability of blood and immune-system stem cells to migrate to the proper spots in the bone marrow of recipient mice and churn out the cell types necessary to reconstitute a damaged immune system by as much as 50%.

Adolescent Stem Cell Donors: Benefits, Burdens, and Risks of Being a Lifeline for a Sibling

Adolescent Stem Cell Donors: Benefits, Burdens, and Risks of Being a Lifeline for a Sibling

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Psychosocial support for donor siblings of bone marrow transplant patients is a significant part of the care provided by the transplant team.

Metastatic Breast Cancer Cells Activate Stem Cell Genes

Metastatic Breast Cancer Cells Activate Stem Cell Genes

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Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track. Now, scientists described studying individual metastatic cells from human breast cancer tumors implanted into mice as the cells escaped into the blood stream and began to form tumors elsewhere in the body.

Risk of cancer in the prostate gland may be caused by exposure to bisphenol A (BPA) during organ development

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A prostate organoid grown from human embryonic stem cells has enabled researchers to show that exposure to bisphenol A (BPA) may increase prostate cancer risk.

Research breakthrough identifies how mutated genes reprogram blood stem cells in leukemia

Research breakthrough identifies how mutated genes reprogram blood stem cells in leukemia

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You research has shed light on the process by which mutated genes in leukemia reprogram blood stem cells and send them spiraling out of control.

Epigenetic driver of glioblastoma provides new therapeutic target

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Using human tumor samples and mouse models, researchers have found that cancer stem cell properties are determined by epigenetic changes.

Stem cells lurking in tumors can resist treatment

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New research indicates that stem cells within tumors can help cancers resist treatment.

Stem cells hidden in tumors may resist treatment

Stem cells hidden in tumors may resist treatment

The ability of cancer stem cells to adapt and resist cancer therapy is a new concern.

Human neural stem cells restore cognitive functions impaired by chemotherapy

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Human neural stem cell treatments may allow for reversal of learning and memory deficits after chemotherapy, according to preclinical research.

Reprogramming stem cells may prevent cancer after radiation

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Radiation makes a stem cell lose its stem-ness, making stem cells damaged by radiation differentiate into other cells that can no longer survive forever.

Human fat may be a Trojan horse in the fight against brain cancer

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Stem cells derived from human body fat have been successfully used to deliver biologic treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.

Cancer-specific stem cell identified for gastric cancer

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Scientists have identified the cancer-specific stem cell that causes gastric cancer. This discovery opens up the possibility of developing new drugs for the treatment of this disease and other types of cancers.

Potential options to attack stem cells in triple-negative breast cancer

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A protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells, according to new research.

Number of cancer stem cells may not predict outcome in HPV-related oral cancers

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The quality of cancer stem cells, rather than their quantity, may be the factor that leads to better survival in certain patients with oral cancer.

Breast cancer stem cell discoveries explain metastasis

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Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers.

Cancer stem cells targeted in malignant brain tumors

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Researchers have also created an experimental vaccine to attack immune system targets related to cancer stem cells, the cells from which malignant brain tumors are believed to originate and regenerate.

Umbilical cord blood stem cells treat leukemia and lymphoma

Umbilical cord blood stem cells treat leukemia and lymphoma

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Growing cord blood stem cells in a laboratory before transplanting them into patients with leukemia, lymphoma, and other blood cancers significantly improves survival, according to a new study.

Breast cancer cell defects linked with lymph node metastases

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Breast tumors that carry breast cancer stem and progenitor cells with mutations in specific oncogenes are significantly more likely than other breast cancers to metastasize to the lymph nodes, researchers reported.

Cell damage seen in smokers with no detectable lung disease

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Smokers who appear to have evaded lung problems actually harbor cells that show early signs of impairment similar to those found in lung cancer, researchers have discovered.

A roundup of FDA news from July 2013

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The FDA has granted orphan drug designation to a cancer stem cell inhibitor known as VS-6063, or defactinib, for use in the treatment of mesothelioma, a rare form of lung cancer.

First human model of PDAC progression via pluripotent stem cells

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An induced pluripotent stem cell line was created from human PDAC, providing the first human-cell model of the early-disease progression of pancreatic cancer.

Chemotherapy nerve damage stops regrowth of blood stem cells

Chemotherapy-induced nerve injury in the bone marrow is what impairs the regeneration of hematopoietic stem cells, leading to anemia.

Stem cells from fat may aid glioblastoma treatment

Adipose tissue may provide a more efficient, less costly, and less invasive source of mesenchymal stem cells (MSCs) than bone marrow.

Shift focus from bad stem cells to good to fight leukemia

Maintaining a viable population of hematopoietic stem cells may be nearly sufficient to eradicate leukemia stem cells from the system.

DNA-repair problems destroy hardy leukemia cells

Leukemia stem cells that overcome drug therapy can be thwarted when deprived of RAD52, a protein key to DNA repair of these cancer cells.

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