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Vemurafenib (Zelboraf)

Bette Weinstein Kaplan, Maribel Pereiras, PharmD, BCPS, BCOP May 11, 2012

Vemurafenib is a B-RAF enzyme inhibitor indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E mutation.

Cabazitaxel (Jevtana)

Bette Weinstein Kaplan April 17, 2012

Cabazitaxel is a taxane derivative indicated for treatment of hormone-refractory metastatic prostate cancer in patients previously treated with a docetaxel-containing regimen.

Asparaginase Erwinia chrysanthemi (Erwinaze)

February 22, 2012

Asparaginase Erwinia chrysanthemi is a component of a multiagent regimen for treatment of acute lymphoblastic leukemia.

Brentuximab vedotin (Adcetris)

Bette Weinstein Kaplan December 19, 2011

An antibody-drug conjugate indicated for the treatment of Hodgkin lymphoma and sALCL after failure of prior multiagent regimens.

Methylnaltrexone (Relistor)

Bette Weinstein Kaplan October 19, 2011

Methylnaltrexone is a peripheral acting narcotic antagonist, opioid reversing agent. It is indicated for treatment of opioid-induced constipation.

Ipilimumab (Yervoy)

August 01, 2011

Ipilimumab is a recombinant, human cytotoxic T-lymphocyte antigen 4-blocking monoclonal antibody indicated for the treatment of unresectable or metastatic melanoma.

Oxaliplatin (Eloxatin)

Bette Weinstein Kaplan April 18, 2011

Oxaliplatin is a platinum-containing antineoplastic agent used to treat lymph node positive colorectal carcinoma and metastatic colorectal cancer.

Fluorouracil IV (5-FU, Adrucil)

March 17, 2011

Fluorouracil is an antimetabolite antineoplastic agent indicated for colorectal, gastric, metastatic breast, metastatic colorectal, and pancreatic cancers.

Cisplatin (Platinol, Platinol-AQ)

February 01, 2011

Cisplatin is a platinum-containing, aklylating agent. It is often used in combination with other chemotherapy agents as well as monotherapy because of its relative lack of hematologic toxicity.

Erlotinib (Tarceva)

Bette Weinstein Kaplan October 26, 2010

Erlotinib is a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor approved for non-small cell lung cancer and pancreatic cancer.

Zoledronic acid (zoledronate, Zometa)

Bette Weinstein Kaplan September 01, 2010

Zoledronic acid is a third-generation bisphosphonate prescribed to reduce pain from bony metastases, treat hypercalcemia of malignancy, and manage osteolytic lesions in multiple myeloma.

Doxorubicin

Bette Weinstein Kaplan August 01, 2010

Doxorubicin is an anthracycline antibiotic that is used to treat lymphoblastic and acute myeloblastic leukemias, several types of cancer, Kaposi sarcoma related to AIDS, malignant lymphoma, soft tissue and osteogenic sarcomas, and Wilms tumor.

Tamoxifen

Bette Weinstein Kaplan July 15, 2010

Stat Consult provides rapid reviews of important drugs used in oncology. This month's column reviews the use of tamoxifen for treatment and prevention of breast cancer.