Squamous Cell Carcinoma

Study Evaluates Systemic Therapy Use With RT Among Older Patients With Head and Neck Cancer

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In contrast of available prospective data, most older patients with locoregionally advanced head and neck cancer are treated with definitive radiotherapy also receive systemic therapy.

Incidence of Oropharyngeal Cancer Increasing Among Older Patients

Incidence of Oropharyngeal Cancer Increasing Among Older Patients

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The incidence of oropharyngeal squamous cell carcinoma is increasing among older patients residing in the United States, likely due to the increase in HPV-associated malignancies.

Radiotherapeutic Bandage Shows Potential as Treatment for Skin Cancer

Radiotherapeutic Bandage Shows Potential as Treatment for Skin Cancer

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A radiotherapeutic bandage is being evaluated by researchers for efficacy against squamous cell carcinoma (SCC) in an animal model. Their results could confirm the viability of a new and improved strategy for the radiotherapeutic treatment of skin cancer in the clinic.

Genetic alterations uncovered in development of skin cancer

Genetic alterations uncovered in development of skin cancer

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Researchers have gained greater insight into the genetic abnormalities that lead the development, progression, and metastasis of skin cancer.

H. pylori may not be risk factor for head and neck squamous cell carcinoma

H. pylori may not be risk factor for head and neck squamous cell carcinoma

Rates of positive serologyand rapid urease tests were not different for head and neck cancer patients and controls, according to researchers.

Oral cancers in different locations in smokers vs nonsmokers

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The relatively high incidence of mouth squamous cell cancer in nonsmokers without obvious causes has been noted in studies, with nonsmokers having a higher proportion of cancers occur on the edge of the tongue.

Prognostic factors identified for peripheral squamous cell cancers of the lung

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Improved survival in patients with a peripheral squamous cell carcinoma has been linked to low blood levels of squamous cell carcinoma antigen or absence of tumor invasion into the space between the lungs and chest wall or into blood vessels.

Investigational drug benefits subgroup of patients with head and neck cancer

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Patients with recurrent or metastatic squamous cell carcinoma of the head and neck may benefit from treatment with the investigational drug dacomitinib.

Early promise from therapy targeting FGFR mutations

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The investigational drug BGJ398 showed promising anticancer activity in patients with various types of cancer driven by FGFR genetic alterations.

Less invasive technique possible for vulvar cancer

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Sentinel lymph node dissection in women with vulvar malignancies allowed gynecologic oncology surgeons to identify and remove just the sentinel nodes and follow the patients for complications and recurrence.

Biomarkers predict effectiveness of radiation treatments for head and neck cancer

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An international team of researchers identified two biomarkers that were good at predicting a patient's resistance to radiation therapy for squamous cell cancer of the head and neck.

Oropharyngeal cancer symptoms vary by HPV status

Oropharyngeal cancer symptoms vary by HPV status

Initial symptom presentation seems to differ for human papillomavirus (HPV)-positive versus HPV-negative patients with oropharyngeal squamous cell carcinoma, according to a study.

Recurrence of squamous cell carcinoma of the oropharynx differs by HPV status

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Patients with HPV-positive squamous cell carcinoma of the oropharynx had a longer time to development of distant metastasis after initial treatment, and had more metastatic sites in more atypical locations.

OPSCC incidence up from 1973 to 2009

OPSCC incidence up from 1973 to 2009

Increased incidence of of oropharyngeal squamous cell carcinoma (OPSCC) among patients younger than 45 years seen, and steady increase in proportion of grade III/IV tumors.

New biomarker for esophageal squamous cell carcinoma

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A biomarker, adenosine deaminase acting on RNA-1 (ADAR1), has been discovered, and it has the potential to improve the diagnosis, prognosis, and treatment of esophageal squamous cell carcinoma.

AACR: Genetic alterations in <i>PAX</i> tied to HNSCC survival

AACR: Genetic alterations in PAX tied to HNSCC survival

Genomic and epigenomic alterations in the PAX gene family are associated with racial disparity in head and neck squamous cell carcinoma (HNSCC) survival, according to a study.

Laser therapy improves common side effect in patients with HNSCC

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A definitive trial has indicated that low-level laser therapy reduces the occurrence of canker sores and improves quality of life in patients with head and neck squamous cell carcinoma who are undergoing concurrent chemoradiotherapy.

HPV raises esophageal cancer risk

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The human papillomavirus (HPV) triples the risk of people developing yet another cancer, esophageal squamous cell carcinoma (ESCC), according to new research.

Lung cancer diagnosis improved by new RNA diagnostic test

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A histology-expression predictor has been developed for the most common types of lung cancer and can corroborate the findings of pathologists.

Squamous-cell carcinoma research advances as protein function identified

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A new function of the IB protein has been identified that is key in the development of squamous-cell carcinoma, a type of skin cancer. The study provides a new tool for the diagnosis of the disease. In the future, this research will enable the identification of novel therapeutic targets to treat this type of cancer.

Genetically diverse head-and-neck tumors have poor outcomes

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The variety of genetic mutations (heterogeneity) of cells within a tumor appears to signal worse clinical outcomes in persons with HNSCC, a recent study demonstrated.

Erlotinib doesn't hurt but doesn't help standard head-and-neck therapy

Adding erlotinib did not increase treatment toxicity in squamous cell carcinoma of the head and neck, but it also did not improve survival.

Researchers document molecular tumor subtypes of head and neck cancer

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HNSCC is the seventh most common form of cancer in the United States. However, other than an association with HPV, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a study has confirmed the presence of four molecular classes of the disease.

Denosumab extended survival in lung cancer with bone metastases

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Denosumab improved overall survival in persons with lung cancer and bone metastases more effectively than did zoledronic acid.

Dual drug therapy delayed treatment resistance in melanoma

Two drugs under FDA evaluation slowed treatment resistance in persons with metastatic malignant melanoma positive for the BRAF protein.

HPV alone not a reliable marker of HPV-driven head/neck cancers

Human papillomavirus (HPV) positivity alone is a poor biomarker for HPV-driven head and neck cancers, according to two recent studies.

ESMO: Dabrafenib &#43; trametinib active in metastatic melanoma

ESMO: Dabrafenib + trametinib active in metastatic melanoma

Combo linked to less squamous cell carcinoma, higher response rates for BRAF V600 disease.

Rapamycin may resolve mucositis

Drugs that inhibit mammalian target of rapamycin (mTOR) stopped radiation-induced damage in mice by protecting cells crucial to tissue repair.

The significance of stress: Early childhood experiences can ­influence recurrence of BCC

The significance of stress: Early childhood experiences can ­influence recurrence of BCC

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New research shows that poor parental relationships can have a lasting impact on cancer risk.

Skin cancer treatment could be as simple as applying moisturizer

Gene-regulation technology to fight skin cancer has the potential to be delivered right through the skin in the form of a moisturizer.

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