Solid Tumors

ESW Technique Improves Nanoparticle Drug Delivery to Solid Tumors with Restricted Blood Flow

ESW Technique Improves Nanoparticle Drug Delivery to Solid Tumors with Restricted Blood Flow

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Combining extracorporeal shock wave (ESW) technique with nanoparticle delivery improves treatment of difficult-to-treat solid tumors, such as anaplastic thyroid cancer.

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

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Oncolytic variants of the HSV-1 have successfully treated melanoma, glioma, and other cancers in adults; in this study, researchers test the effectiveness of an oncolytic HSV-1 in pediatric patients.

PAD4 Inhibition Repairs, Reverses Cancer Tumor-Induced Kidney Damage

PAD4 Inhibition Repairs, Reverses Cancer Tumor-Induced Kidney Damage

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A potential treatment targeting neutrophils holds promise for limiting kidney damage and improving renal function in cancer.

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

Biopolymer Delivery of Synergistic Immunotherapy Could Improve Efficacy

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Biopolymer codelivery of CAR T cells and stimulator of IFN genes directly to the surface of solid tumors more effectively reduced tumor size.

Multiscale Modeling Framework Predicts Tumor Growth

Multiscale Modeling Framework Predicts Tumor Growth

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Researchers from 3 Texas institutions collaborated on a multiscale framework for modeling tumor growth, with potential to inform growth patterns and tumor density.

Including a PI3-Kinase Inhibitor with an PARP Inhibitor Improves Tumor Shrinkage in Patients with Resistant Ovarian Cancer

Including a PI3-Kinase Inhibitor with an PARP Inhibitor Improves Tumor Shrinkage in Patients with Resistant Ovarian Cancer

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Tumor shrinkage was seen in plantinum-resistant ovarian tumors when treated with a combination of a PARP inhibitor and an alpha-specific PI3-kinase inhibitor.

AntiCancer, Rheumatoid Arthritis Drug Combination Produced Synergistic Attack on Tumor Cells

AntiCancer, Rheumatoid Arthritis Drug Combination Produced Synergistic Attack on Tumor Cells

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The combination of an anticancer agent with a rheumatoid arthritis medication results in synergistic effect that improves the efficacy of the anticancer agent.

Metronomic Chemotherapy: Improved Tumor Blood Supply Leads to Better Treatment

Metronomic Chemotherapy: Improved Tumor Blood Supply Leads to Better Treatment

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The mechanism of metronomic chemotherapy: Improved tumor blood supply leads to better treatment .

Attaching an Anticancer Payload to Platelets Shows Promise Against Postsurgical Recurrence

Attaching an Anticancer Payload to Platelets Shows Promise Against Postsurgical Recurrence

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Researchers develop novel strategy for delivering immunotherapy agents to tumor surgical sites to eradicate tumor cells left behind after resection and reduce risk of recurrence.

Technique Maps Biomarkers That Predict Immunotherapy Response

Technique Maps Biomarkers That Predict Immunotherapy Response

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With only 1 slide of a tumor section, an analysis of multiple tumor markers can be performed. The technique may help predict response to immunotherapy, which typically evokes responses in only a small group of patients.

Novel Nanoparticle Achieves Concomitant Tumor Cell Death and Resistance Suppression

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Resistance to therapy through adaptation poses a major hurdle for cancer therapy. Bioengineers addressed this by creating a single nanoparticle that comprises a synergistic drug pair that shuts down mechanisms of resistance to a degree that has not been previously achieved.

Photodynamic Cancer Therapy Holds Promise as an Noninvasive Option for Tumor Resection

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A single dose and a beam of light can kill up to 95% of cancer cells in 2 hours, according to preclinical research on a novel approach to tumor resection. Photodynamic cancer therapy may be a treatment option for people whose tumors are inoperable or hard-to-reach.

Widely Prescribed Pain and Anti-inflammation Drug Decreased Cancer Growth

Widely Prescribed Pain and Anti-inflammation Drug Decreased Cancer Growth

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A widely prescribed pain/anti-inflammatory medication reduced the growth of neurofibromatosis type 2 tumors in mice and in cell cultures, suggesting that the drug could reduce tumor growth in some cancers.

Tumor Regression Achieved With LOXO-101 in Phase 1 Study

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Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.

Research Tests Effectiveness of T Cell Receptor Therapy on Solid Tumors in Animal Models

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Gene therapy with a T cell receptor targeting a single cancer-specific point mutation is being used to eradicate large solid tumors.

Potential Drug Targets Are Identified With Finding That Genes in the Ly6 Gene Family Drive Tumorigenesis and Poor Prognosis

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Lower patient survival and worse clinical outcomes across a variety of cancer types were correlated with increased expression of 4 genes in the Ly6 gene family. These findings came from an analysis of 130 gene expression studies from 10 solid cancers.

Liquid Biopsy Provides A More Comprehensive View of Genetic Changes Occurring in Cancer Tumors

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Analyzing tumor DNA fragments in the bloodstream, known as circulating tumor DNA (ctDNA), may offer a more complete view of a patient's cancer from a molecular perspective.

Optical Probes That Illuminate Solid Tumors in Surgery Move One Step Closer to Reality

Optical Probes That Illuminate Solid Tumors in Surgery Move One Step Closer to Reality

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Optical probes that make cancer cells glow and improve surgical tumor removal are in phase I and II clinical trials in humans. The probes could be commonplace in the next 5 to 10 years, hypothesize the researchers.

Early Trial Results Show Novel Injectable Enables Complete Visualization for Resection of Tumors

Early Trial Results Show Novel Injectable Enables Complete Visualization for Resection of Tumors

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A new injectable agent causes cancer cells in a tumor to fluoresce, potentially enabling surgeons to locate and remove all of a cancerous tumor on the first attempt.

Extra Biopsies in Clinical Trials Often Have No Impact on Drug Dose or Use in Cancer Treatments

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Extra biopsies performed solely to study the pharmacodynamics of a new anticancer drug have no impact on subsequent drug development or on how physicians use these new drugs to treat future patients.

Mix of Cell Types in Cancer Tumor Samples May Bias Genomic Analyses

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Genetic analyses and other tests performed by both researchers and physicians can be significantly skewed when normal cells, especially immune cells, are intermixed with cancerous cells in a tissue sample.

Identifying Genetic Drivers of Breast Cancer Tumors and Metastasis

Identifying Genetic Drivers of Breast Cancer Tumors and Metastasis

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A novel genetic driver analysis of matched breast cancer primary tumors and multiorgan metastases suggests that most genetic drivers in a single tumor are based on DNA copy number variants (CNV), are established early, and are maintained in metastases. These findings were presented at the 2015 San Antonio Breast Cancer Symposium.

Mathematical Modeling Can Help Predict Impact of Surgery on Cancer Metastasis

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The size of a surgically removed tumor is generally thought to relate to the risk of metastasis; however, tumor cells metastasize at different times therefore the rate of spread is difficult to assess. A mathematical model was developed to calculate the relationship between tumor size and the relative risk of recurrence after surgery.

Using MRI to Follow Magnetic Nanoparticles Predicts Effectiveness of Response to Nanotherapeutics

An FDA-approved, magnetic nanoparticle and MRI identifies tumors most likely to respond to drugs delivered via nanoparticles.

Tumors May Seed Cancer Metastases Earlier Than Expected

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A new study has found an additional mechanism explaining how EGFR, a molecule long linked to cancer progression appears, to seed the body with metastatic cells long before doctors would typically detect a primary tumor.

Laser-Based Tool Could Increase Accuracy and Safety of Brain Tumor Surgery

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A new laser-based microscope technology may help surgeons see the difference between tumor tissue and normal brain tissue in real-time.

Childhood Brain Tumors Affect Working Memory of Adult Survivors

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Adult survivors of childhood brain tumors have lower working memory performance compared with healthy adults, according to research from Georgia State University and Emory University, in Atlanta.

Surgical Probe Distinguishes Between Tumor Margins and Healthy Tissue

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A new surgical tool that uses light to ensure surgeons removed all of a cancerous tumor was found to correlate well with traditional pathologists' diagnoses, according to a clinical study showing that the tool could soon enable reliable, real-time surgical guidance.

Exercise slows tumor growth and improves chemotherapy

Exercise slows tumor growth and improves chemotherapy

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A new study of the impact of exercise in models of breast cancer in mice has shown the benefits of exercise on the function of blood vessels around tumors.

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