Skin Cancer

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

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The FDA approved the indication expansion for ipilimumab based on evidence from 2 clinical trials evaluating its safety and efficacy in pediatric patients.

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

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Five-year survival rate found similar to observation despite a significant improvement in disease-free interval.

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

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A common beta blocker, carvedilol, is found to have preventive properties against the sun-induced cell damage that leads to skin cancer.

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

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Two-gene pigmented lesion test classifies skin lesions as melanoma or nonmelanoma, helping with diagnostic challenges faced with the visual image and pattern recognition approach.

Assessment of Melanoma Screening Practices Produces Data-Driven, Risk-Based Guidelines

Assessment of Melanoma Screening Practices Produces Data-Driven, Risk-Based Guidelines

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Dermatologist assessment of screening practices addresses the lack of a national consensus on screening guidelines for melanoma.

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Patients with psoriasis had 1.53 times greater risk of developing a malignancy, regardless of the type of psoriasis therapy they are receiving.

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

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Despite their efficacy in metastatic melanoma, KIs include risk of serious side effects in patients. This overview explains the effects and management recommendations for 4 agents used to treat metastatic melanoma.

Dabrafenib + Trametinib Rechallenge Active in Pretreated Melanoma

Dabrafenib + Trametinib Rechallenge Active in Pretreated Melanoma

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Rechallenge with dabrafenib plus trametinib demonstrated antitumor activity in patients who had previously progressed on BRAF inhibitor therapy.

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

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Rosiglitazone has potential for older patients with melanoma who develop resistance to targeted therapies.

Indoor Tanning Costs United States Millions of Dollars in Health Care Costs

Indoor Tanning Costs United States Millions of Dollars in Health Care Costs

Skin cancers from ultraviolet light in tanning devices totaled $343.1 million in 2015 alone, researchers say.

Cost-Effectiveness of Immunotherapy for Advanced Melanoma Evaluated

Cost-Effectiveness of Immunotherapy for Advanced Melanoma Evaluated

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Researchers sought to conduct a cost-effectiveness analysis of immunotherapy for patients with advanced melanoma.

Trends in Behaviors, Medical Practice Indicate Mortality From Melanoma Will Decline

Trends in Behaviors, Medical Practice Indicate Mortality From Melanoma Will Decline

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Using statistical models, predictions were made for death rates from melanoma in 3 three countries and based on availability of a treatment.

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

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Researchers compared the ability of an artificial-intelligence algorithm to recognize and classify skin cancers with the clinical evaluations of dermatologists.

IFN Induction No Better Than Observation for Intermediate-risk Melanoma

IFN Induction No Better Than Observation for Intermediate-risk Melanoma

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Induction therapy with intravenous interferon α-2b appeared to be no better than observation alone for the management of patients with intermediate-risk melanoma.

A New Targeted Approach Suggested for Virus-Related Cancers

A New Targeted Approach Suggested for Virus-Related Cancers

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Researchers may have uncovered a way to target treatment for cancers that have a viral component.

Risk of Skin Cancer Does Not Dissuade Most College Students Who Tan Indoors

Risk of Skin Cancer Does Not Dissuade Most College Students Who Tan Indoors

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Despite being aware of the risks, college students continued to use tanning beds, a study found.

Customers Find Useful Information in Results from Direct-to-Consumer Genetic Testing

Customers Find Useful Information in Results from Direct-to-Consumer Genetic Testing

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Results of a series of Internet surveys revealed customers' perceptions of harms, benefits, and limitations of genetic information received from direct-to-consumer genetic testing.

Beach Umbrella Not Enough for Protection from UV Rays

Beach Umbrella Not Enough for Protection from UV Rays

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Comparison studied the effectiveness of sun protection offered by a beach umbrella alone with that of sunscreen with a high sun protection factor.

Melanoma Incidence Still on the Rise in Parts of the United States

Melanoma Incidence Still on the Rise in Parts of the United States

Melanoma incidence varies by region, and many states have experienced an increase.

Topical Combination Reduces Actinic Keratosis Lesions, Reducing Risk of Squamous Cell Carcinoma

Topical Combination Reduces Actinic Keratosis Lesions, Reducing Risk of Squamous Cell Carcinoma

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Study investigates the effectiveness of a topical treatment with an immune system-activator and a topical chemotherapy on actinic keratosis, a precursor to squamous cell carcinoma.

Imaging Using FCM Analysis Aids Surgical Removal of Tumors From Eyelid

Imaging Using FCM Analysis Aids Surgical Removal of Tumors From Eyelid

Current study evaluated reflectance mode, horizontal scanning for removal of eyelid basal cell carcinoma.

Alcohol Consumption, Particularly White Wine, Associated With Increased Risk of Melanoma

Alcohol Consumption, Particularly White Wine, Associated With Increased Risk of Melanoma

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A review of data from three large, prospective studies examined a potential association between alcoholic beverage consumption and risk of melanoma.

Study Identifies Factors Associated With Outcomes After Dabrafenib + Trametinib

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Despite the effectiveness of dabrafenib in combination with trametinib for metastatic BRAF-mutant melanoma, many patients experience disease progression that often leads to death. In this data analysis, researcher sought to identify clinical factors associated with long-term response and survival.

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

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Atlhough survival for patients with advanced melanoma is similar with both targeted therapies and immunotherapies, a review of the literature reveals why one of them may be a better choice as first-line therapy.

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

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Neurotoxicity is not uncommon in patients with melanoma treated with immune checkpoint inhibitors. In this study, therefore, researchers sought to examine the incidence of neurotoxicity across anti-CTLA-4 and anti-PD-1 antibodies at a single institution.

More Than Half of Melanomas Are Self-Detected, Especially by Women

More Than Half of Melanomas Are Self-Detected, Especially by Women

More melanomas are self-detected by women; men tend to have more melanomas in less visible locations.

Psychoeducational Intervention Effective for Reducing Fear of Melanoma Recurrence

Psychoeducational Intervention Effective for Reducing Fear of Melanoma Recurrence

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A newly developed, evidence-based psychoeducational intervention effectively reduced fear of cancer recurrence and stress in patients at high risk for developing another melanoma.

Risk for Skin Cancer Higher in Organ Transplant Recipients

Risk for Skin Cancer Higher in Organ Transplant Recipients

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Organ transplant recipients of all races/ethnicities are at higher risk for skin cancer, therefore routine, annual total-body skin cancer screenings should be a part of post organ transplant care.

HRQoL Better Maintained With Pembrolizumab in Ipilimumab-refractory Melanoma

HRQoL Better Maintained With Pembrolizumab in Ipilimumab-refractory Melanoma

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Treatment with pembrolizumab better maintained health-related quality of life compared with chemotherapy in patients with advanced melanoma refractory to ipilimumab.

Cutaneous Basal Cell Carcinoma Arising Within a Keloid Scar: A Case Report

Cutaneous Basal Cell Carcinoma Arising Within a Keloid Scar: A Case Report

[OncoTargets and Therapy] This research presents a rare case of a secondary tumor (BCC) which arose on top of a primary tumor (keloid scar) on the right auricle region in a healthy 23-year-old woman.

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