Skin Cancer

Study Identifies Factors Associated With Outcomes After Dabrafenib + Trametinib

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Despite the effectiveness of dabrafenib in combination with trametinib for metastatic BRAF-mutant melanoma, many patients experience disease progression that often leads to death. In this data analysis, researcher sought to identify clinical factors associated with long-term response and survival.

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

PD-1 Inhibitors Ideal for First-Line Therapy in Treatment-Naïve Advanced Melanoma

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Atlhough survival for patients with advanced melanoma is similar with both targeted therapies and immunotherapies, a review of the literature reveals why one of them may be a better choice as first-line therapy.

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

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Neurotoxicity is not uncommon in patients with melanoma treated with immune checkpoint inhibitors. In this study, therefore, researchers sought to examine the incidence of neurotoxicity across anti-CTLA-4 and anti-PD-1 antibodies at a single institution.

More Than Half of Melanomas Are Self-Detected, Especially by Women

More Than Half of Melanomas Are Self-Detected, Especially by Women

More melanomas are self-detected by women; men tend to have more melanomas in less visible locations.

Psychoeducational Intervention Effective for Reducing Fear of Melanoma Recurrence

Psychoeducational Intervention Effective for Reducing Fear of Melanoma Recurrence

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A newly developed, evidence-based psychoeducational intervention effectively reduced fear of cancer recurrence and stress in patients at high risk for developing another melanoma.

Risk for Skin Cancer Higher in Organ Transplant Recipients

Risk for Skin Cancer Higher in Organ Transplant Recipients

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Organ transplant recipients of all races/ethnicities are at higher risk for skin cancer, therefore routine, annual total-body skin cancer screenings should be a part of post organ transplant care.

HRQoL Better Maintained With Pembrolizumab in Ipilimumab-refractory Melanoma

HRQoL Better Maintained With Pembrolizumab in Ipilimumab-refractory Melanoma

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Treatment with pembrolizumab better maintained health-related quality of life compared with chemotherapy in patients with advanced melanoma refractory to ipilimumab.

Cutaneous Basal Cell Carcinoma Arising Within a Keloid Scar: A Case Report

Cutaneous Basal Cell Carcinoma Arising Within a Keloid Scar: A Case Report

[OncoTargets and Therapy] This research presents a rare case of a secondary tumor (BCC) which arose on top of a primary tumor (keloid scar) on the right auricle region in a healthy 23-year-old woman.

Supportive Care Needs Assessed in Localized Cutaneous Melanoma

Supportive Care Needs Assessed in Localized Cutaneous Melanoma

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Patients with localized melanoma see their supportive care needs peak at their initial cancer diagnosis and if they experience disease recurrence.

Users Support Indoor Tanning Device Age Restrictions, Stronger Health Warnings, But Not Total Ban

Users Support Indoor Tanning Device Age Restrictions, Stronger Health Warnings, But Not Total Ban

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Three-quarters of young adult women who visit indoor tanning salons support stronger restrictions on their use.

Study Supports Use of PD-1 Inhibitors in Acral, Mucosal Melanomas

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Response rates with PD-1 inhibitors in patients with acral and mucosal melanomas were similar to previously reported rates in patients with cutaneous melanoma.

Some Gene Variants Increase the Risk for Melanoma in People With Red Hair, Freckling

Some Gene Variants Increase the Risk for Melanoma in People With Red Hair, Freckling

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Variants of the MC1R gene, associated with red hair, pale skin, and freckles, increases the number of genetic mutations related to skin cancer and the level of other gene mutations, further increasing the risk for skin cancer.

Data Confirm Benefit of Cobimetinib and Vemurafenib in Melanoma

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Cobimetinib in combination with vemurafenib as a standard first-line approach improves survival in patients with BRAF V600 mutation-positive melanoma, updated results of the coBRIM study.

USPSTF: Evidence Lacking to Recommend Full-body Skin Cancer Screens

USPSTF: Evidence Lacking to Recommend Full-body Skin Cancer Screens

New report doesn't change Task Force's prior statement on skin cancer screening issued in 2009

Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries

Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries

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Training primary care providers (PCP) to detect early melanoma led to increased melanoma diagnoses, but had little impact on skin surgeries or dermatology visits.

De Novo Melanomas May Be More Aggressive Than Nevus-associated Lesions

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De novo melanomas, which arise from clinically normal skin with no associated nevus, may be more aggressive than nevus-associated melanomas.

Nivolumab Maintains Baseline HRQoL in Advanced Melanoma

Nivolumab Maintains Baseline HRQoL in Advanced Melanoma

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In addition to improving overall survival compared with dacarbazine in patients with advanced melanoma, nivolumab maintains baseline levels of health-related quality of life to ultimately confer long-term quality of survival benefit.

Cause of Pain of Photodynamic Therapy Identified

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Exaggerated sensitivity to harmless light, or photosensitization, is often triggered by photodynamic therapy used to treat precancerous skin lesions and skin cancers.

Primary Care Melanoma Screening Does Not Cause Major Adverse Consequences

Primary Care Melanoma Screening Does Not Cause Major Adverse Consequences

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Population-based screening for melanoma performed by primary care providers does not cause substantial harm with respect to skin surgeries and dermatology visits.

Topical Skin Creams Are Effective in Treatment of Superficial Basal Cell Carcinoma

Topical Skin Creams Are Effective in Treatment of Superficial Basal Cell Carcinoma

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Results from a clinical trial indicate that 2 topical creams compared favorably to photodynamic therapy for primary, low-risk superficial basal cell carcinoma.

Disease-Free Status Is Achieved by Combining Immunotherapy Treatments in Patient With Metastatic Melanoma

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A patient with refractory metastatic melanoma was successfully treated with a novel combination of 2 different types of immunotherapy.

Soles of the Feet Should Also Be Checked for Skin Cancer

Soles of the Feet Should Also Be Checked for Skin Cancer

Cutaneous melanoma is rare on feet, but often advanced at point of diagnosis.

Melanoma: Pembrolizumab Better Than Ipilimumab Regardless of PD-L1 Expression

Melanoma: Pembrolizumab Better Than Ipilimumab Regardless of PD-L1 Expression

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Pembrolizumab provides benefit over ipilimumab in patients with advanced melanoma, regardless of tumor PD-L1 expression status or number of prior therapies, a study presented at the 2016 ASCO Annual Meeting has shown.

Modified Thiazole Benzenesulfonamide Demonstrates Anticancer Activity in Melanoma

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A newly discovered synthesized drug reduced the viability of melanoma cells without affecting normal cells in cell culture and mouse xenograft models of the disease. The drug, HA15, is a type of thiazole benzenesulfonamide.

Combination of Radiation and Immunotherapy Shows Promise in Melanoma

Combination of Radiation and Immunotherapy Shows Promise in Melanoma

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Combining radiation treatments with a new generation of immunotherapies is showing promise in the treatment of melanoma, according to a recent review.

Adhering to Patient Preferences Improves Patient Comfort During Skin Cancer Screening

Adhering to Patient Preferences Improves Patient Comfort During Skin Cancer Screening

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To improve patient comfort during full-body skin cancer screenings, dermatologists should respect patients' preferences for the gender of the examining clinician and for how the genital area is examined.

A Protein Could Predict the Response to Immunotherapy in Metastatic Melanoma

A Protein Could Predict the Response to Immunotherapy in Metastatic Melanoma

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The Bim protein might predict which patients could be successfully treated with immunotherapy for metastatic melanoma.

ATS: Aggressive Melanoma Linked to Untreated Sleep Apnea

ATS: Aggressive Melanoma Linked to Untreated Sleep Apnea

New study highlights the importance of diagnosing and treating obstructive sleep apnea because of possible cancer connection.

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

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The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.

Developments in Intralesional Therapy for Metastatic Melanoma

Developments in Intralesional Therapy for Metastatic Melanoma

[Cancer Control] This research explores the efficacy of intralesional therapy as a treatment option for patients with unresectable, locally advanced, or metastatic melanoma.

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