Side-effect Management

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

[Cancer Management and Research] This research explores the feasibility of group exercise intervention using strength and aerobic training for patients with metastatic cancer undergoing chemotherapy.

Fertility Preservation in Male Adolescents and Young Adults With Cancer

Fertility Preservation in Male Adolescents and Young Adults With Cancer

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Increasing survival rates for AYA patients with cancer have heightened the importance of discussing fertility preservation options. In this column, we review the options for male patients and the significance of including a discussion of them as part of treatment planning.

Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue

Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue

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A meta-analysis of studies determined the effectiveness of acupuncture in relieving cancer-related fatigue in patients with cancer, comparing the alternative treatment with sham acupuncture, typical care, and American ginseng.

FDA Discontinues ESA APPRISE Risk Evaluation and Mitigation Strategy Program

FDA Discontinues ESA APPRISE Risk Evaluation and Mitigation Strategy Program

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Why was the ESA APPRISE risk evaluation and mitigation strategy program discontinued?

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

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A small study of 50 patients undergoing FOLFOX for CRC determined if adding aprepitant to standard antiemetic prophylactic treatment would improve CINV in this patient population.

Intervention Model Helps Cancer Survivors Overcome Fear of Recurrence

Intervention Model Helps Cancer Survivors Overcome Fear of Recurrence

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A randomized study assessed the impact of ConquerFear, a novel intervention developed from various models of cognitive therapy, and Taking-it-Easy, an intervention based on models that promote relaxation, on cancer survivors' ability to manage their fear of cancer recurrence.

Netupitant Plus Palonosetron Safe, Effective Strategy for CINV in Lung Cancer

Netupitant Plus Palonosetron Safe, Effective Strategy for CINV in Lung Cancer

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A post-hoc analysis of 2 clinical trials was conducted to determine the safety and effectiveness of NEPA for managing CINV in patients with lung cancer who received platinum-based chemotherapy.

Fosaprepitant for CINV Prevention Dose Proportional in Older Pediatric Patients

Fosaprepitant for CINV Prevention Dose Proportional in Older Pediatric Patients

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Fosaprepitant is used to prevent CINV in adult patients, and this phase 2b dose-ranging study of pediatric patients aged newborn to 17 years determined the appropriate doses for younger patients.

Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases

Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases

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A phase 3 study demonstrated the impact of nurse-led education on pain vs care as usual in terms of number of patients reporting pain scores.

Adolescents With Cancer May Derive Benefit From Skills-targeted Interventions

Adolescents With Cancer May Derive Benefit From Skills-targeted Interventions

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Investigators randomly assigned 100 adolescents and young adults with cancer ages 12 to 25 years old 1:1 to the PRISM intervention or to non-directive usual psychosocial care.

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

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In this case, a female patient with advanced lung cancer experiences a rare episode of nivolumab-induced Herzmyasthenie, emphasizing the need to be aware of the potential for rapid myocarditis concomitant with MG in patients undergoing treatment with anti-PD-1 monoclonal antibodies.

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

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Results of the double-blinded and initial open-label phases of the ELECT Study demonstrate the effectiveness of lanreotide in controlling diarrhea and flushing in patients with NETs presenting with carcinoid syndrome.

Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP

Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP

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Previous studies determined the effectiveness of 6 months of therapy with eltrombopag in patients with ITP. In this analysis, researchers extended 4 clinical trials to assess efficacy and safety of eltrombopag therapy for more than 6 months in patients with ITP.

Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer

Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer

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A randomized study was conducted to determine the efficacy of prophylactic prochlorperazine in reducing opioid-induced nausea and vomiting in patients with cancer receiving opioids for pain management.

Specialized Interventions Reduce Aberrant Opioid Behaviors in Cancer Patients

Specialized Interventions Reduce Aberrant Opioid Behaviors in Cancer Patients

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Investigators the effectiveness of an intervention to reduce aberrant opioid-related behavior and use of opioids in patients with cancer receiving chronic opioid therapy.

Defibrotide an Effective Option for SOS/VOD in Patients Undergoing HSCT

Defibrotide an Effective Option for SOS/VOD in Patients Undergoing HSCT

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Sinusoidal obstruction syndrome (or hepatic veno-occlusive disease), a complication observed in patients who undergo HSCT, is managed with defibrotide. In this study, investigators assessed its efficacy and patient response to therapy.

Complications and Management of Coagulation Disorders in Leukemia Patients

Complications and Management of Coagulation Disorders in Leukemia Patients

[Blood and Lymphatic Cancer: Targets and Therapy] Investigators conduct 4 case studies that illustrate a range of coagulation disorders that can develop in patients with leukemia to elucidate the rationale and process of specific treatment options.

Naldemedine Effective for Opioid-Induced Constipation in Cancer Pain

Naldemedine Effective for Opioid-Induced Constipation in Cancer Pain

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Opioids are an effective option for managing cancer pain; however, opioid-induced constipation (OIC) detracts from their effectiveness. In this study, investigators sought to determine if naldemedine use improved OIC without reducing pain relief.

DVD Motivated Patients to Exercise for Managing Fatigue in Breast Cancer

DVD Motivated Patients to Exercise for Managing Fatigue in Breast Cancer

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Patients with breast cancer experiencing fatigue need to be encouraged to exercise. In this study, investigators measured the impact of enhancing oncologist recommendations with a yoga-based DVD.

Spontaneous Tumor Lysis Syndrome in Recently Diagnosed Small Cell Lung Cancer

Spontaneous Tumor Lysis Syndrome in Recently Diagnosed Small Cell Lung Cancer

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This case demonstrates that, although rare, spontaneous TLS can occur even in the absence of chemotherapy, and a high index of suspicion for the effect should be maintained when patients with malignancies demonstrate the classic symptom of laboratory abnormalities.

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

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A double-blind study compared the effectiveness of lorazepam plus haloperidol with haloperidol alone in reducing agitation in patients with advanced cancer.

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

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Intractable hiccups can be especially problematic in the advanced cancer and palliative care settings. Dr Thompson, an oncology pharmacist, reviews options for effective medical management of this condition.

Multivitamin Use May Reduce Risk of Chemo-Induced Neuropathy

Multivitamin Use May Reduce Risk of Chemo-Induced Neuropathy

Use of multivitamins prior to a breast cancer diagnosis is associated with reduced symptoms of peripheral neuropathy.

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

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Quality of life for patients with CIPN was improved by wearing frozen gloves during treatment. Researchers reported in an oral presentation at ESMO 2017 Congress that the gloves reduced symptoms even though long-term differences in neuropathy were not observed.

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

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Patients with multiple myeloma treated with daratumumab who experience IRRs may easily be managed by administering pre-infusion and postinfusion medications, investigators reported in a presentation at ESMO 2017 Congress.

Adding Thalidomide to Palonosetron, Dexamethasone Reduces CINV

Adding Thalidomide to Palonosetron, Dexamethasone Reduces CINV

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Delayed CINV was improved significantly in patients receiving highly emetogenic chemotherapy for cancer when thalidomide was added to palonosetron and dexamethasone regimen.

Two FDA Approvals Propel CAR T Cell Therapy Into the Limelight

Two FDA Approvals Propel CAR T Cell Therapy Into the Limelight

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The first FDA approval of a CAR T cell therapy is granted for the treatment of B-cell precursor ALL. FDA also approves rheumatoid arthritis medication for the management of cytokine release syndrome, a common and serious adverse effect of CAR T cell therapy

Breakthrough Cancer Pain Managed Effectively With Fentanyl Buccal Tablets

Breakthrough Cancer Pain Managed Effectively With Fentanyl Buccal Tablets

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This prospective, noninterventional trial evaluated the response of 276 patients to FBT from 64 pain and oncology clinics

Combination of Western Care With Chinese Medicine Shows Potential in ITP

Combination of Western Care With Chinese Medicine Shows Potential in ITP

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The pathogenesis of idiopathic thrombocytopenic purpura (ITP) may be associated with Th17 helper T cells.

Distress Assessments Improve Psychosocial Support Referrals for HNC Patients

Distress Assessments Improve Psychosocial Support Referrals for HNC Patients

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A quality improvement project demonstrates that routine distress assessment using the NCCN DT/PL in patients with head and neck cancers improves referrals for psychosocial services.

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