Side-effect Management

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

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FDA issues black box warning for rolapitant regarding the potential for anaphylaxis, anaphylactic shock, and other hypersensitivity reactions in patients receiving the injectable emulsion for CINV prophylaxis.

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

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A retrospective chart study demonstrated the effectiveness of fosfomycin as an antibacterial prophylaxis for febrile neutropenia in patients with hematologic cancer.

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

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Evidence from previous studies for patients with ovarian and endometrial cancers has suggested that goshajinkigan may treat and prevent CIPN.

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

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For this study, researchers sought to determine the effect exercise would have on severity of symptoms for patients who develop CIPN after taxane, platinum, or vinca alkaloid based chemotherapy.

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

A survey of pediatric oncology providers including physicians, nurses, and social workers reveals their willingness to consider medical marijuana for children with cancer, as well as their reasons against its use in these patients.

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

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A retrospective study, presented at ASH 2017, determined the effectiveness of aspirin in reducing risk of VTE in patients with multiple myeloma at high risk of developing VTE.

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

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Data presented at ASH 2017 illustrates the effectiveness of 2 prophylactic antiemetic regimens in pediatric patients receiving moderately or highly emetogenic chemotherapy.

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

Bioimpedance Spectroscopy Reduces Chronic BCRL in High-Risk Breast Cancer

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Results of a study evaluating the effectiveness of bioimpedance spectroscopy in reducing incidence of chronic breast cancer-related lymphedema (BCRL) in high-risk patients with breast cancer were presented at SABCS 2017.

Best Antiemetic Therapies for Alleviating CINV: A Literature Review

Best Antiemetic Therapies for Alleviating CINV: A Literature Review

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A review of 12 antiemetic regimens identified 3 that may be more effective than conventional regimens, a study presented at SABCS 2017 has shown.

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

Bisphosphonates vs Denosumab: Preventing SREs in Breast Cancer With Bone Metastasis

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A comparison study presented at the 2017 SABCS sought to determine the effectiveness of bisphosphonates with denosumab for skeletal-related events in women with breast cancer metastases to bone.

More Communication, Support Needed to Manage Symptom Burden in CML

More Communication, Support Needed to Manage Symptom Burden in CML

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Despite advancements in treatment of CML, many patients still experience adverse effects of their disease and treatments. Therefore, researchers conducted a survey of patients to determine whether they felt assistance and support met their needs.

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

Efficacy of Curcumin in Reducing Radiation Dermatitis Severity Assessed

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A phase 2, randomized study investigated the effectiveness of oral curcumin, a component of turmeric, in reducing radiation dermatitis severity in patients undergoing radiation therapy for breast cancer.

Opioid Epidemic Response May Be Limiting Cancer-Related Pain Management

Opioid Epidemic Response May Be Limiting Cancer-Related Pain Management

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A report on current legislation and practice trends regarding opioids and how they are affecting cancer patients' ability to manage their pain.

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

Loratadine Reduced Bone Pain Associated With Breast Cancer Treatment

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Results of an open-label study demonstrated the effectiveness of loratadine in the management of bone pain in patients with breast cancer undergoing chemotherapy and receiving supportive therapy with pegfilgrastim.

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

Duloxetine May Improve AI-Associated Joint Pain in Early Stage Breast Cancer

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Patients with early-stage breast cancer treated with aromatase inhibitors often experience adverse events that lead to discontinuation. In this phase 3 study, researchers sought to determine if duloxetine could manage these symptoms.

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

[Cancer Management and Research] This research explores the feasibility of group exercise intervention using strength and aerobic training for patients with metastatic cancer undergoing chemotherapy.

Fertility Preservation in Male Adolescents and Young Adults With Cancer

Fertility Preservation in Male Adolescents and Young Adults With Cancer

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Increasing survival rates for AYA patients with cancer have heightened the importance of discussing fertility preservation options. In this column, we review the options for male patients and the significance of including a discussion of them as part of treatment planning.

Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue

Acupuncture an Effective Alternative Treatment for Cancer-Related Fatigue

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A meta-analysis of studies determined the effectiveness of acupuncture in relieving cancer-related fatigue in patients with cancer, comparing the alternative treatment with sham acupuncture, typical care, and American ginseng.

FDA Discontinues ESA APPRISE Risk Evaluation and Mitigation Strategy Program

FDA Discontinues ESA APPRISE Risk Evaluation and Mitigation Strategy Program

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Why was the ESA APPRISE risk evaluation and mitigation strategy program discontinued?

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

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A small study of 50 patients undergoing FOLFOX for CRC determined if adding aprepitant to standard antiemetic prophylactic treatment would improve CINV in this patient population.

Intervention Model Helps Cancer Survivors Overcome Fear of Recurrence

Intervention Model Helps Cancer Survivors Overcome Fear of Recurrence

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A randomized study assessed the impact of ConquerFear, a novel intervention developed from various models of cognitive therapy, and Taking-it-Easy, an intervention based on models that promote relaxation, on cancer survivors' ability to manage their fear of cancer recurrence.

Netupitant Plus Palonosetron Safe, Effective Strategy for CINV in Lung Cancer

Netupitant Plus Palonosetron Safe, Effective Strategy for CINV in Lung Cancer

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A post-hoc analysis of 2 clinical trials was conducted to determine the safety and effectiveness of NEPA for managing CINV in patients with lung cancer who received platinum-based chemotherapy.

Fosaprepitant for CINV Prevention Dose Proportional in Older Pediatric Patients

Fosaprepitant for CINV Prevention Dose Proportional in Older Pediatric Patients

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Fosaprepitant is used to prevent CINV in adult patients, and this phase 2b dose-ranging study of pediatric patients aged newborn to 17 years determined the appropriate doses for younger patients.

Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases

Pain Control More Easily Achieved With Nurse-Led Education in Bone Metastases

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A phase 3 study demonstrated the impact of nurse-led education on pain vs care as usual in terms of number of patients reporting pain scores.

Adolescents With Cancer May Derive Benefit From Skills-targeted Interventions

Adolescents With Cancer May Derive Benefit From Skills-targeted Interventions

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Investigators randomly assigned 100 adolescents and young adults with cancer ages 12 to 25 years old 1:1 to the PRISM intervention or to non-directive usual psychosocial care.

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

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In this case, a female patient with advanced lung cancer experiences a rare episode of nivolumab-induced Herzmyasthenie, emphasizing the need to be aware of the potential for rapid myocarditis concomitant with MG in patients undergoing treatment with anti-PD-1 monoclonal antibodies.

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

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Results of the double-blinded and initial open-label phases of the ELECT Study demonstrate the effectiveness of lanreotide in controlling diarrhea and flushing in patients with NETs presenting with carcinoid syndrome.

Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP

Long-Term Eltrombopag Increases Platelet Counts, Decreases Bleeding in ITP

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Previous studies determined the effectiveness of 6 months of therapy with eltrombopag in patients with ITP. In this analysis, researchers extended 4 clinical trials to assess efficacy and safety of eltrombopag therapy for more than 6 months in patients with ITP.

Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer

Prophylactic Prochloperazine Ineffective for Opioid-induced Nausea/Vomiting in Cancer

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A randomized study was conducted to determine the efficacy of prophylactic prochlorperazine in reducing opioid-induced nausea and vomiting in patients with cancer receiving opioids for pain management.

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