Side-effect Management

Comprehensive Report Looks at Benefits and Harms of Medical Cannabis

Comprehensive Report Looks at Benefits and Harms of Medical Cannabis

Oral cannabinoids can ease chronic pain and chemotherapy-related nausea, but researchers cite risks, as well.

Hypnosis and Its Use in Cancer Treatment

Hypnosis and Its Use in Cancer Treatment

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A cursory look at hypnosis and where it may be used to offer an alternative and side-effect-free management of several aspects of care that can be beneficial to patients with cancer.

Menopause-specific QoL Changes Associated With Chemoprevention Nonadherence

Menopause-specific QoL Changes Associated With Chemoprevention Nonadherence

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A cohort of participants in the MAP.3 trial completed the MENQOL questionnaire, and the findings shed light on the influence of changes in menopause-specific quality of life on aromatase inhibitor adherence in women at high risk for breast cancer.

Diarrhea Common But Manageable With Pertuzumab-containing Regimens

Diarrhea Common But Manageable With Pertuzumab-containing Regimens

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Because treatment with pertuzumab could include adverse events similar to those observed with EGFR antagonists, such as diarrhea, researchers evaluated participants from 3 trials to determine the incidence and severity of diarrhea observed with pertuzumab.

Serum IL-12 May Predict for Chemotherapy-Related Fatigue in Early-Stage Breast Cancer

Serum IL-12 May Predict for Chemotherapy-Related Fatigue in Early-Stage Breast Cancer

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In this study, researchers sought to identify physical, neurocognitive, and serologic markers that may correlate with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer.

Adding Aprepitant Not Superior to Ondansetron Monotherapy for UA-RINV

Adding Aprepitant Not Superior to Ondansetron Monotherapy for UA-RINV

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Many patients can still experience UA-RINV despite prophylactic therapy; therefore, researchers explored the effectiveness and safety of dual prophylactic therapy with an NK1 receptor antagonist and a 5-HT3 receptor antagonist.

Tissue Factor May Predict for Recurrent VTE in Patients Receiving Anticoagulants

Tissue Factor May Predict for Recurrent VTE in Patients Receiving Anticoagulants

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An evaluation of the association of tissue factor, clinical risk factors, and other biomarkers measured at the time of initial VTE with recurrent VTE helps determine their predictive value for patients at high risk.

Optimal Timing of Influenza Vaccination in Patients Receiving Chemotherapy

Optimal Timing of Influenza Vaccination in Patients Receiving Chemotherapy

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A comparison of administering the influenza vaccine concurrently with chemotherapy with that of administration within the cytopenic period during 3-week chemotherapy cycles determined which schedule was the optimal timing for vaccination administration in this group.

Patients With Breast Cancer Report More Cognitive Difficulties After Chemotherapy

Patients With Breast Cancer Report More Cognitive Difficulties After Chemotherapy

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Researchers sought to evaluate the incidence of cancer-related cognitive impairment in patients with breast cancer in a large prospective, longitudinal, nationwide study. These findings address limitations in previous research.

Scalp-cooling Device To Reduce Chemotherapy-related Alopecia

Scalp-cooling Device To Reduce Chemotherapy-related Alopecia

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A new system appears efficacious in preventing chemotherapy-related alopecia in women with breast cancer, according to a study presented at SABCS 2016.

Menopause-related Nausea/Vomiting and Headaches Effects Tamoxifen Adherence

Menopause-related Nausea/Vomiting and Headaches Effects Tamoxifen Adherence

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Women who experienced menopause-related side effects were significantly less likely to adhere to their assigned tamoxifen therapy.

Loperamide Regimen May Reduce Diarrhea in Neratinib-treated Patients

Loperamide Regimen May Reduce Diarrhea in Neratinib-treated Patients

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Investigators report on the efficacy of a structured prophylactic regimen of loperamide for 2 cycles to reduce incidence and severity of neratinib-associated diarrhea in patients with HER2-positive early-stage breast cancer, at SABCS 2016.

Netupitant/Palonosetron Efficacious for Prevention of N/V in Patients Receiving MEC or HEC

Netupitant/Palonosetron Efficacious for Prevention of N/V in Patients Receiving MEC or HEC

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In a poster presentation at SABCS 2016, researchers reported on the efficacy and safety of netupitant/palonosetron (NEPA) for the prevention of CINV in patients receiving highly or moderately emetogenic chemotherapy.

Arsenic Pretreatment May Protect Normal Tissue During Chemo in Breast Cancer

Arsenic Pretreatment May Protect Normal Tissue During Chemo in Breast Cancer

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Researchers found that temporary pretreatment with LDA may protect normal breast tissue during chemotherapy for breast cancer in patients undergoing breast-conserving therapy, according to a study presented at SABCS 2016.

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

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Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, and the beta blocker bisoprolol protected against trastuzumab-related declines.

Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome

Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome

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In patients with tumor lysis syndrome, rasburicase was significantly more effective in treating hyperuricemia and was associated with significantly shorter ICU stay.

Technique for Minimizing Chemotherapy-Induced Alopecia Gaining a Foothold in the States

Technique for Minimizing Chemotherapy-Induced Alopecia Gaining a Foothold in the States

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Inducing vasoconstriction in the scalp of patients with breast cancer undergoing chemotherapy effectively reduces the amount of drug that reaches the hair follicles and hair-cell metabolism, minimizing one of the most dreaded side effects of treatment.

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

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Researchers examined the frequency of TKI-induced hemorrhagic colitis among patients with CML treated with dasatinib and evaluated the efficacy of screening with a fecal occult blood test followed by colonoscopy in this patient population.

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

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Loss of bone density related to chemotherapy and adjuvant therapy for breast cancer can lead to debilitating hip and vertebral fractures. This discussion discusses the impact of resistance training for these patients.

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

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Large cohort study assesses the frequency of, and factors associated with, ototoxicity in childhood cancer survivors who received platinum agents without cranial irradiation.

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

The feasibility of an estradiol-releasing vaginal ring vs intravaginal testosterone cream for women with HR-positive stage I to III breast cancer using aromatase inhibitors who reported vaginal dryness, decreased libido, or dyspareunia is evaluated in a phase 2 study.

MASCC/ESMO Update Guidelines for CINV Prophylaxis

MASCC/ESMO Update Guidelines for CINV Prophylaxis

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The Multinational Association of Supportive Care in Cancer (MASCC) and the European Society for Medical Oncology (ESMO) have updated their recommendations for the prevention of nausea and vomiting following multiple-day chemotherapy.

Substantial Number of Patients Receiving Unnecessary Antiemetic Prescriptions

Substantial Number of Patients Receiving Unnecessary Antiemetic Prescriptions

Guidelines recommend against the use of antiemetic agents in patients receiving chemotherapy with low or minimal emetic risk as it is associated with increased health care costs and potential risks to the patient without a need to prevent CINV. In this study, researchers examined the pattern of overprescribing prophylactic antiemetic drugs in Japan.

Gene Therapy Alleviates Doxorubicin-Induced Cardiotoxicity

Gene Therapy Alleviates Doxorubicin-Induced Cardiotoxicity

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Doxorubicin, commonly used to treat many cancers, can cause cumulative cardiac atrophy and body wasting in patients receiving the drug. Researchers investigated the potential of gene therapy to reverse those effects.

Web-based Rehab Program Improved Cognitive Symptoms in Cancer Survivors

Web-based Rehab Program Improved Cognitive Symptoms in Cancer Survivors

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Insight, a web-based cognitive rehabilitation program, was evaluated for its potential in improving self-reported cognitive symptoms in cancer survivors.

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

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Researchers report on the feasibility of a nurse-led sexual rehabilitation intervention to target sexual recovery and vaginal dilation in women who underwent pelvic radiation therapy and brachytherapy for gynecologic cancers.

Study Identifies Factors Associated With Infection-related Complications in ALL

Study Identifies Factors Associated With Infection-related Complications in ALL

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Data on neutropenia and infection-related complications in patients with ALL are lacking; therefore, this study focused on identifying the characteristics and risk factors of infection-related complications in children with newly diagnosed ALL.

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

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Neurotoxicity is not uncommon in patients with melanoma treated with immune checkpoint inhibitors. In this study, therefore, researchers sought to examine the incidence of neurotoxicity across anti-CTLA-4 and anti-PD-1 antibodies at a single institution.

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

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This study focused on determining the effectiveness of a short-term high-intensity interval training (HIIT) program to improve patients' cardiorespiratory fitness prior to NSCLC resection.

Pseudohyperkalemia: False Potassium Levels Occur in a Patient With Lymphoma

Pseudohyperkalemia: False Potassium Levels Occur in a Patient With Lymphoma

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The patient's history and current blood work results indicated a dangerously high potassium level. But a meticulously handled redraw proved it false.

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