Side-effect Management

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling

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Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, and the beta blocker bisoprolol protected against trastuzumab-related declines.

Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome

Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome

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In patients with tumor lysis syndrome, rasburicase was significantly more effective in treating hyperuricemia and was associated with significantly shorter ICU stay.

Technique for Minimizing Chemotherapy-Induced Alopecia Gaining a Foothold in the States

Technique for Minimizing Chemotherapy-Induced Alopecia Gaining a Foothold in the States

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Inducing vasoconstriction in the scalp of patients with breast cancer undergoing chemotherapy effectively reduces the amount of drug that reaches the hair follicles and hair-cell metabolism, minimizing one of the most dreaded side effects of treatment.

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

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Researchers examined the frequency of TKI-induced hemorrhagic colitis among patients with CML treated with dasatinib and evaluated the efficacy of screening with a fecal occult blood test followed by colonoscopy in this patient population.

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

Resistance Training Improves Posttreatment Outcomes for Breast Cancer Survivors

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Loss of bone density related to chemotherapy and adjuvant therapy for breast cancer can lead to debilitating hip and vertebral fractures. This discussion discusses the impact of resistance training for these patients.

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

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Large cohort study assesses the frequency of, and factors associated with, ototoxicity in childhood cancer survivors who received platinum agents without cranial irradiation.

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

The feasibility of an estradiol-releasing vaginal ring vs intravaginal testosterone cream for women with HR-positive stage I to III breast cancer using aromatase inhibitors who reported vaginal dryness, decreased libido, or dyspareunia is evaluated in a phase 2 study.

MASCC/ESMO Update Guidelines for CINV Prophylaxis

MASCC/ESMO Update Guidelines for CINV Prophylaxis

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The Multinational Association of Supportive Care in Cancer (MASCC) and the European Society for Medical Oncology (ESMO) have updated their recommendations for the prevention of nausea and vomiting following multiple-day chemotherapy.

Substantial Number of Patients Receiving Unnecessary Antiemetic Prescriptions

Substantial Number of Patients Receiving Unnecessary Antiemetic Prescriptions

Guidelines recommend against the use of antiemetic agents in patients receiving chemotherapy with low or minimal emetic risk as it is associated with increased health care costs and potential risks to the patient without a need to prevent CINV. In this study, researchers examined the pattern of overprescribing prophylactic antiemetic drugs in Japan.

Gene Therapy Alleviates Doxorubicin-Induced Cardiotoxicity

Gene Therapy Alleviates Doxorubicin-Induced Cardiotoxicity

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Doxorubicin, commonly used to treat many cancers, can cause cumulative cardiac atrophy and body wasting in patients receiving the drug. Researchers investigated the potential of gene therapy to reverse those effects.

Web-based Rehab Program Improved Cognitive Symptoms in Cancer Survivors

Web-based Rehab Program Improved Cognitive Symptoms in Cancer Survivors

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Insight, a web-based cognitive rehabilitation program, was evaluated for its potential in improving self-reported cognitive symptoms in cancer survivors.

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

Pilot Study Assesses Feasibility of Nurse-led Sexual Rehabilitation Program

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Researchers report on the feasibility of a nurse-led sexual rehabilitation intervention to target sexual recovery and vaginal dilation in women who underwent pelvic radiation therapy and brachytherapy for gynecologic cancers.

Study Identifies Factors Associated With Infection-related Complications in ALL

Study Identifies Factors Associated With Infection-related Complications in ALL

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Data on neutropenia and infection-related complications in patients with ALL are lacking; therefore, this study focused on identifying the characteristics and risk factors of infection-related complications in children with newly diagnosed ALL.

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

Immune Checkpoint-Related Neurotoxicity May Be More Common During Combination Treatment

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Neurotoxicity is not uncommon in patients with melanoma treated with immune checkpoint inhibitors. In this study, therefore, researchers sought to examine the incidence of neurotoxicity across anti-CTLA-4 and anti-PD-1 antibodies at a single institution.

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

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This study focused on determining the effectiveness of a short-term high-intensity interval training (HIIT) program to improve patients' cardiorespiratory fitness prior to NSCLC resection.

Pseudohyperkalemia: False Potassium Levels Occur in a Patient With Lymphoma

Pseudohyperkalemia: False Potassium Levels Occur in a Patient With Lymphoma

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The patient's history and current blood work results indicated a dangerously high potassium level. But a meticulously handled redraw proved it false.

Levofloxacin Prophylaxis May Reduce Infection Rate in Relapsed/Refractory AML

Levofloxacin Prophylaxis May Reduce Infection Rate in Relapsed/Refractory AML

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This study evaluated whether antibacterial prophylaxis effectively reduced the rate of infections overall for patients receiving intensive chemotherapy for relapsed/refractory AML.

Olanzapine Efficacious for Treatment of Breakthrough CINV

Olanzapine Efficacious for Treatment of Breakthrough CINV

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This study compared the effectiveness of olazapine, palonosetron, and ondansetron in the treatment of CINV in patients receiving HSCT who are refractory to prophylactic antiemetic agents.

Androgen Deprivation Therapy for Prostate Cancer May Increase Dementia Risk

Androgen Deprivation Therapy for Prostate Cancer May Increase Dementia Risk

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Growing evidence suggests a link between androgen deprivation therapy (ADT) and cognitive dysfunction, but whether it may contribute to the risk of dementia more broadly is unclear. In this study, researchers examined the association of ADT with subsequent development of dementia in patients with prostate cancer.

Study Confirms Long-term Risk of VTE in Patients With Breast Cancer

Study Confirms Long-term Risk of VTE in Patients With Breast Cancer

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Patients with breast cancer have more than 2 times the risk for developing a venous thromboembolism 5 years after diagnosis compared with the general population.

Expectations of Chemotherapy Side Effects Influence Patients' Experiences During Breast Cancer Treatment

Expectations of Chemotherapy Side Effects Influence Patients' Experiences During Breast Cancer Treatment

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Recent studies indicate that adverse side effects can result from factors unrelated to the pharmacologic agent, but rather from other factors.

Naldemedine May Improve Opioid-Induced Constipation in Patients With Cancer

Naldemedine May Improve Opioid-Induced Constipation in Patients With Cancer

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Treatment with naldemedine improved opioid-induced consiptation in a timely manner and was well tolerated in patients with cancer.

G-CSF May Only Modestly Prevent Neutropenia-related Hospitalization

G-CSF May Only Modestly Prevent Neutropenia-related Hospitalization

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Primary prophylaxis with granulocyte colony-stimulating factor provided only a low-to-modest benefit in reducing neutropenia-related hospitalization in patients with breast cancer receiving low-to-intermediate risk chemotherapy regimens.

Kinase Inhibitors: Managing Side Effects in GI Cancers

Kinase Inhibitors: Managing Side Effects in GI Cancers

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A review of adverse effects and recommended management for 3 kinase inhibitors indicated for the treatment of gastrointestinal cancers.

Low-dose Dexamethasone Premedication May Be Preferred for Weekly Docetaxel Regimens

Low-dose Dexamethasone Premedication May Be Preferred for Weekly Docetaxel Regimens

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Low-dose dexamethasone may be preferred as a premedication protocol for patients receiving weekly docetaxel regimens due a significantly lower risk of infection compared with a higher dose regimen.

G-CSF Prophylaxis May Modestly Reduce Neutropenia-related Hospitalization

G-CSF Prophylaxis May Modestly Reduce Neutropenia-related Hospitalization

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Primary prophylaxis with G-CSF may modestly reduce neutropenia-related hospitalization in patients with breast cancer receiving docetaxel and cyclophosphamide or docetaxel, carboplatin, and trastuzumab.

Ciprofloxacin May Prevent Bacteremia in Patients Undergoing Auto-HSCT

Ciprofloxacin May Prevent Bacteremia in Patients Undergoing Auto-HSCT

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Antibacterial prophylaxis with the flouroquinolone, ciprofloxacin, substantially reduced the risk of bacteremia and neutropenic fever in patients with multiple myeloma or lymphoma undergoing high-dose chemotherapy and auto-HSCT.

Bioimpedence Spectroscopy Improves Early Detection of Breast Cancer-Related Lymphedema in At-Risk Patients

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Bioimpedance spectroscopy (BIS) effectively assesses for subclinical breast cancer-related lymphedema in patients at risk, and accurately assess patients for response to treatment.

Overuse of Antiemetics Prevalent Among Patients Receiving Low Emetogenic Chemo

Overuse of Antiemetics Prevalent Among Patients Receiving Low Emetogenic Chemo

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Antiemetic overuse is prevalent among patients with cancer receiving emetogenic chemotherapy and leads to unnecessary spending.

Rolapitant Improves CINV Prevention in Patients With GI Cancers

Rolapitant Improves CINV Prevention in Patients With GI Cancers

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Adding rolapitant to a 5-HT3 receptor antagonist and dexamethasone significantly improved the prevention of CINV in patients with GI and CRC cancers receiving highly or moderately emetogenic chemotherapy.

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