Side-effect Management

Delayed Administration Device for Pegfilgratim Safe, Effective in Preventing Grade 4 Neutropenia

Delayed Administration Device for Pegfilgratim Safe, Effective in Preventing Grade 4 Neutropenia

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In a comparison study, the Onpro® device was found to be a safe and effective alternative to manual injection of pegfilgrastim in patients receiving chemotherapy.

Managing Dermatologic Adverse Events in Patients Receiving Third-Generation EGFR-TKIs

Managing Dermatologic Adverse Events in Patients Receiving Third-Generation EGFR-TKIs

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An international team reviews osimertinib-associated dermatologic adverse events in patients treated with the third-generation EGFR-TKI.

Assessment Tool for Immunotherapy Side Effects

Assessment Tool for Immunotherapy Side Effects

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My patient is receiving immunotherapy. What is the best tool for assessing side effects?

Opioid Overdose Statistics Among Cancer Population Is Different From General Population

Opioid Overdose Statistics Among Cancer Population Is Different From General Population

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Researchers sought to determine the incidence and demographic factors of patients with cancer whose deaths were attributed to opioid overdose over a 10-year period.

Immune Checkpoint Inhibitors: A Review of Side Effects, Their Causes and Incidence

Immune Checkpoint Inhibitors: A Review of Side Effects, Their Causes and Incidence

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A multicenter research team determined the incidence and type of fatal toxic effects associated with immune checkpoint inhibitors.

Nedaplatin vs Cisplatin for Malignancy-Induced MPE: Noninferior, Less Toxicity

Nedaplatin vs Cisplatin for Malignancy-Induced MPE: Noninferior, Less Toxicity

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Researchers sought to determine if nedaplatin could effectively manage malignancy-induced MPE in patients with cancer with less toxicity than cisplatin.

Metronidazole, Vancomycin Recommended for <i>C Difficile</i> in Pediatric Oncology, HSCT

Metronidazole, Vancomycin Recommended for C Difficile in Pediatric Oncology, HSCT

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An international multidisciplinary panel of experts in pediatric oncology and infectious diseases convened to develop recommendations for the prevention and treatment of C difficile infection in pediatric patients with cancer or who are undergoing HSCT.

Integrating Preoperative Oral Care Into Cancer Treatment Plans

Integrating Preoperative Oral Care Into Cancer Treatment Plans

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Oral care by a dentist was found to reduce pathogenic bacterial plaque thereby decreasing the risk of postoperative pneumonia, a potentially fatal adverse effect, in patients undergoing surgical procedures for cancer.

New Formulations Improve Management of Chemotherapy-Induced Nausea and Vomiting

New Formulations Improve Management of Chemotherapy-Induced Nausea and Vomiting

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In a recent report, researchers evaluate the efficacy of newer 5HT3-RAs for the prevention of CINV in patients with cancer receiving moderately or highly emetogenic chemotherapy.

Pre-HSCT Conditioning May Improve Physical Functioning in Hematologic Cancers

Pre-HSCT Conditioning May Improve Physical Functioning in Hematologic Cancers

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In this retrospective study, researchers assessed the outcomes of 88 patients with hematologic disease who underwent HSCT.

Oral Hydration Effectively Reduced Risk of Nephrotoxity After Cisplatin

Oral Hydration Effectively Reduced Risk of Nephrotoxity After Cisplatin

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A single-center retrospective study determined the safety of IV hydration before and oral hydration after cisplatin therapy to prevent nephrotoxicity in patients with lung cancer vs IV hydration both before and after therapy.

Hepatocellular Cancer Pain: Impact and Management Challenges

Hepatocellular Cancer Pain: Impact and Management Challenges

[Journal of Hepatocellular Carcinoma] A review of the manifestations, treatments, and challenges associated with hepatocellular cancer pain.

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

Nonmyeloablative/Reduced-Intensity Conditioning May Reduce Mucositis in HCT

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Researchers sought to determine if NMA or reduced-intensity conditioning with busulfan improved severity/duration of oral mucositis compared with myeloablative conditioning in patients with hematologic cancer undergoing HCT.

Alternate Dosing of Ruxolitinib May Alleviate Anemia in Myelofibrosis

Alternate Dosing of Ruxolitinib May Alleviate Anemia in Myelofibrosis

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In a phase 2 study, researchers assessed the efficacy of using a dose-escalation approach to lessen the occurrence and severity of anemia in MF treated with ruxolitinib.

Improved Pain Scores With Acupuncture for Arthralgia in Breast Cancer Not Clinically Meaningful

Improved Pain Scores With Acupuncture for Arthralgia in Breast Cancer Not Clinically Meaningful

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In a multicenter study, researchers sought to determine if acupuncture effectively relieved aromatase inhibitor-related joint pain in patients with breast cancer.

Lorazepam Did Not Improve CINV in Pediatric Acute Lymphoblastic Leukemia

Lorazepam Did Not Improve CINV in Pediatric Acute Lymphoblastic Leukemia

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A retrospective chart review was conducted to determine if adding lorazepam to granisetron would improve CINV prevention in pediatric patients with newly diagnosed ALL.

Propolis Mouthwash Treatment Effectively Eases Severe Oral Mucositis

Propolis Mouthwash Treatment Effectively Eases Severe Oral Mucositis

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In this systematic review, investigators sought to determine the safety, effectiveness, and tolerability of propolis mouthwash in preventing severe oral mucositis in patients undergoing chemotherapy or radiotherapy.

Hypnosis: A Comparison of the Efficacy of an Intervention Across Patient Populations

Hypnosis: A Comparison of the Efficacy of an Intervention Across Patient Populations

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Researchers sought to determine if men with prostate cancer would derive the same benefits from hypnosis as women with breast cancer. Their results highlight significant differences in what is helpful for men vs women.

Staff Education Leads to Increase in Oncology Rehabilitation Referrals

Staff Education Leads to Increase in Oncology Rehabilitation Referrals

Educational intervention for oncology clinicians at a rural Michigan oncology clinic does not demonstrate a statistically significant increase in referrals to rehabilitation; however, results show a clinically significant improvement in identification of need, communication among staff, and potential for greater referrals.

Data on Corticosteroid-Related Adverse Events in Advanced Cancer Are Lacking, Needed

Data on Corticosteroid-Related Adverse Events in Advanced Cancer Are Lacking, Needed

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Although corticosteroids are frequently used to manage adverse effects (AEs), data on AEs related to these agents are lacking. Therefore, these researchers sought to determine if better reporting of corticosteroid-related AEs would be of benefit.

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer

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In a randomized study, researchers sought to determine the effect of IV injections of coix seed oil, a Chinese CAM, on pain and quality of life measures for patients with advanced cancer.

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

Handgrip Force May Provide Objective Evaluation of Cancer-Related Fatigue

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Researchers sought to determine if handgrip force could provide objective measures of CRF in patients with cancer.

CALM: A Depression Intervention for Cancer Patients at the End of Life

CALM: A Depression Intervention for Cancer Patients at the End of Life

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The effectiveness of a novel intervention intended to reduce and/or prevent depression in patients with advanced cancer at the end of life was investigated in a randomized study with more than 300 patients.

PTSD May Increase Symptom Burden in Patients With Cancer

PTSD May Increase Symptom Burden in Patients With Cancer

Post-traumatic stress symptoms are linked to a greater symptom burden in hospitalized cancer patients.

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

Live or Online Mindfulness-Based Cognitive Therapy Reduced Cancer-Related Psychological Distress

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Mindfulness-based interventions are proven effective in helping patients with cancer manage distress and other psychological symptoms. In this study, researchers sought to determine if Internet-based MBCT can be as effective as face-to-face interventions.

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life

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In this retrospective study, researchers sought to determine the effectiveness of fentanyl for dyspnea in dying patients with advanced cancer.

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

Muscle Loss Not Always Correlated With Loss of Function, Strength in Cancer Cachexia

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Interventions specifically designed to target cachexia in patients with thoracic or gastrointestinal cancer and established cachexia were effective in helping patients preserve functional stability and rehabilitation potential.

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

Primary Prophylaxis Key in Reducing Febrile Neutropenia in Early Breast Cancer

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In a retrospective study, researchers investigated the effect of primary prophylaxis on incidence of febrile neutropenia in patients with early stage breast cancer.

Radiation-Induced Esophagitis: A Common, Debilitating Clinical Challenge in Thoracic Radiotherapy

Radiation-Induced Esophagitis: A Common, Debilitating Clinical Challenge in Thoracic Radiotherapy

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A review of current options and ongoing trials for managing ARIE, a common esophageal adverse effect caused by radiotherapy to the thoracic region for lung, breast, or head and neck cancers, or lymphoma.

Dexrazoxane May Reduce Cardiotoxicity in Pediatric AML

Dexrazoxane May Reduce Cardiotoxicity in Pediatric AML

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Children's Oncology Group study reported on the effect of dexrazoxane on cardiotoxicity of anthracycline-containing regimens in pediatric patients with AML at the 2018 ASCO Annual Meeting.

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