Side-effect Management

Elevated Pre-HCT Iron Levels Predictive of Worse Survival Outcomes in AML/MDS

Elevated Pre-HCT Iron Levels Predictive of Worse Survival Outcomes in AML/MDS

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The ALLIVE trial sought to determine if eLPI levels were predictive of iron-related toxicity and mortality after HCT in patients with AML or MDS.

HMB/Arg/Gln Does Not Reduce Oral Mucositis Incidence in Head and Neck Cancer

HMB/Arg/Gln Does Not Reduce Oral Mucositis Incidence in Head and Neck Cancer

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In a phase 2 study, researchers sought to determine the effectiveness of adding HMB/Arg/Gln to cisplatin-based chemoradiotherapy for patients with head and cancers to prevent CRT-induced oral mucositis.

Olanzapine Use to Prevent Chemotherapy-Induced Nausea and Vomiting

Olanzapine Use to Prevent Chemotherapy-Induced Nausea and Vomiting

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Why is the antipsychotic olanzapine (Zyprexa) being used to prevent nausea?

Palliative Sedation a Valid Option for Refractory Symptoms in End-stage Cancer

Palliative Sedation a Valid Option for Refractory Symptoms in End-stage Cancer

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A prospective study was conducted to determine the effectiveness of palliative sedation for patients with terminal illnesses who experience refractory symptoms.

Palonosetron Noninferior to Ondansetron for Pediatric Chemotherapy-induced Vomiting

Palonosetron Noninferior to Ondansetron for Pediatric Chemotherapy-induced Vomiting

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In a prospective study, researchers sought to determine the noninferiority of palonosetron to ondansetron in pediatric patients with cancer receiving moderate or high emetogenic chemotherapy.

Ciprofloxacin Plus Doxycycline Reduces Infection Rate in Multiple Myeloma Post-ASCT

Ciprofloxacin Plus Doxycycline Reduces Infection Rate in Multiple Myeloma Post-ASCT

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A health outcomes analysis of 419 patients with multiple myeloma sought to determine if cipro-doxy was more effective than cipro alone in reducing the incidence of neutropenic fever and infections, both significant causes of morbidity and death for these patients.

Nabilone Improves Cancer-Associated Anorexia in Lung Cancer

Nabilone Improves Cancer-Associated Anorexia in Lung Cancer

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Researchers assessed the efficacy of nabilone for improving symptoms of anorexia in patients with NSCLC. In addition, patient appetite, quality of life, and nutritional status were also assessed.

Outcomes in SCCHN Improved With Swap of Docetaxel for 5-FU in Palliative Regimen

Outcomes in SCCHN Improved With Swap of Docetaxel for 5-FU in Palliative Regimen

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Study results show the effect on high-grade toxicity when 5-FU is replaced with docetaxel in the EXTREME regimen in the palliative treatment of patients with metastatic SCCHN.

Approach and Management of Checkpoint Inhibitor-related Immune Hepatitis

Approach and Management of Checkpoint Inhibitor-related Immune Hepatitis

[Journal of Gastrointestinal Oncology] A review of diagnostic parameters and management modalities for checkpoint inhibitor-induced hepatic toxicity is presented.

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

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Reintegration to the general environment, particularly to school, can be challenging for survivors of childhood cancers. This review discusses how adverse effects such as chemo brain may present extra challenges for these patients and what can be done to ease patients' anxiety.

Intervention Improves Breast Cancer Survivors' Memory Contentment

Intervention Improves Breast Cancer Survivors' Memory Contentment

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Results of a prospective study demonstrated the effectiveness of a 1-hour psychoeducational intervention designed to help survivors of breast cancer manage their chemotherapy-related cognitive dysfunction and improve their memory contentment.

Advances in Prevention, Treatment of RT-Associated Radiodermatitis Hold Promise

Advances in Prevention, Treatment of RT-Associated Radiodermatitis Hold Promise

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This review of radiodermatitis, a common adverse effect of radiation therapy, discusses preventive and treatment options available that reduce and/or minimize symptoms of the condition.

Monitoring Patients With Chronic Lymphocytic Leukemia  Treated With Venetoclax

Monitoring Patients With Chronic Lymphocytic Leukemia Treated With Venetoclax

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What are key monitoring guidelines for patients with CLL being treated with venetoclax?

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

Calcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer Survivors

In this study, researchers determined the efficacy of calcitriol, weight-bearing exercise, both, or daily multivitamins on bone formation and resorption in breast cancer survivors actively maintained on hormone therapy.

Complementary and Alternative Medicine Practices of Lymphoma Survivors in South Korea

Complementary and Alternative Medicine Practices of Lymphoma Survivors in South Korea

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A study from South Korea determined the prevalence and type of CAM practices lymphoma survivors used for various purposes including ease symptoms, augment treatment, boost immunity, and gain a sense of control.

Zinc Sulfate Improves Chemotherapy-Induced Mucositis Outcomes in Leukemia

Zinc Sulfate Improves Chemotherapy-Induced Mucositis Outcomes in Leukemia

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Results of a triple-blind study demonstrate effectiveness of zinc sulfate in preventing chemotherapy-induced mucositis or reducing its incidence and severity in patients with leukemia receiving chemotherapy.

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

Cisplatin-Induced Adverse Events in Osteosarcoma Not Improved With Pantoprazole

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This phase 2 study sought to determine whether concurrent pantoprazole would improve cisplatin-induced ototoxicity and nephrotoxicity in younger patients with osteosarcoma.

Cachexia Not Improved With Celecoxib Plus Megestrol vs Megestrol Alone

Cachexia Not Improved With Celecoxib Plus Megestrol vs Megestrol Alone

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Double-blind phase 3 study evaluated the effect of megestrol combined with celecoxib vs monotherapy on cachexia in patients with gastrointestinal cancer.

Self-guided Cognitive Behavioral Pain Management Shows Efficacy in Painful CIPN

Self-guided Cognitive Behavioral Pain Management Shows Efficacy in Painful CIPN

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Self-guided online cognitive behavioral pain management may result in improved "worst" pain but not "average" pain compared with usual care for the treatment of painful chemotherapy-induced peripheral neuropathy.

Prevention, Management of Hand-Foot Syndrome With Cooling Therapy

Prevention, Management of Hand-Foot Syndrome With Cooling Therapy

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Researchers explored the effectiveness of wearing frozen gloves and socks before and after treatment with PLD to prevent or manage hand-foot syndrome in patients with ovarian cancer.

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

Acupuncture Benefits Aromatase Inhibitor-Related Joint Pain

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Acupuncture may represent an effective adjuvant therapy in the management of joint pain associated with aromatase inhibitor treatment in postmenopausal women with breast cancer.

Resolving Vaginal Dryness in Women With a History of Breast Cancer

Resolving Vaginal Dryness in Women With a History of Breast Cancer

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What are some nonhormonal treatments that can improve vaginal dryness in women with a history of breast cancer?

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

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FDA issues black box warning for rolapitant regarding the potential for anaphylaxis, anaphylactic shock, and other hypersensitivity reactions in patients receiving the injectable emulsion for CINV prophylaxis.

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

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A retrospective chart study demonstrated the effectiveness of fosfomycin as an antibacterial prophylaxis for febrile neutropenia in patients with hematologic cancer.

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

Goshajinkigan May Not Prevent Chemotherapy-induced Peripheral Neuropathy in Cancer

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Evidence from previous studies for patients with ovarian and endometrial cancers has suggested that goshajinkigan may treat and prevent CIPN.

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

Exercise Reduces Severity of Chemotherapy-Induced Peripheral Neuropathy

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For this study, researchers sought to determine the effect exercise would have on severity of symptoms for patients who develop CIPN after taxane, platinum, or vinca alkaloid based chemotherapy.

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

A survey of pediatric oncology providers including physicians, nurses, and social workers reveals their willingness to consider medical marijuana for children with cancer, as well as their reasons against its use in these patients.

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

Aspirin Does Not Reduce Risk of Venous Thromboembolism in Multiple Myeloma

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A retrospective study, presented at ASH 2017, determined the effectiveness of aspirin in reducing risk of VTE in patients with multiple myeloma at high risk of developing VTE.

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

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Data presented at ASH 2017 illustrates the effectiveness of 2 prophylactic antiemetic regimens in pediatric patients receiving moderately or highly emetogenic chemotherapy.

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