Side Effects

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

A Case of Immunotherapy-Induced Myocarditis Concomitant to MG in Lung Cancer

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In this case, a female patient with advanced lung cancer experiences a rare episode of nivolumab-induced Herzmyasthenie, emphasizing the need to be aware of the potential for rapid myocarditis concomitant with MG in patients undergoing treatment with anti-PD-1 monoclonal antibodies.

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

Lanreotide Effectively Controls Diarrhea, Flushing in Neuroendocrine Tumors

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Results of the double-blinded and initial open-label phases of the ELECT Study demonstrate the effectiveness of lanreotide in controlling diarrhea and flushing in patients with NETs presenting with carcinoid syndrome.

Neurotoxicity After CAR T-cell Therapy May Be Associated With Endothelial Activation

Neurotoxicity After CAR T-cell Therapy May Be Associated With Endothelial Activation

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Despite its high response rate, researchers are finding that patients with endothelial activation prior to lymphodepletion chemotherapy are at greater risk of neurologic adverse events after undergoing CAR T-cell therapy for relapsed/refractory B-ALL, CLL, or NHL.

Disruptions to Circadian Rhythm Linked to Prostate Cancer Surgery Regret

Disruptions to Circadian Rhythm Linked to Prostate Cancer Surgery Regret

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A survey followed up with an assessment via validated tools determined that patients with prostate cancer who experienced regret after radical prostatectomy were more susceptible to depression-associated sleep disorders.

Complications and Management of Coagulation Disorders in Leukemia Patients

Complications and Management of Coagulation Disorders in Leukemia Patients

[Blood and Lymphatic Cancer: Targets and Therapy] Investigators conduct 4 case studies that illustrate a range of coagulation disorders that can develop in patients with leukemia to elucidate the rationale and process of specific treatment options.

Symptoms, Economic Burden Reduce QoL in Gastrointestinal Cancer Survivors

Symptoms, Economic Burden Reduce QoL in Gastrointestinal Cancer Survivors

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A cross-sectional survey revealed the impact of symptoms and economic burden on quality of life for survivors of gastrointestinal cancer.

Naldemedine Effective for Opioid-Induced Constipation in Cancer Pain

Naldemedine Effective for Opioid-Induced Constipation in Cancer Pain

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Opioids are an effective option for managing cancer pain; however, opioid-induced constipation (OIC) detracts from their effectiveness. In this study, investigators sought to determine if naldemedine use improved OIC without reducing pain relief.

Spontaneous Tumor Lysis Syndrome in Recently Diagnosed Small Cell Lung Cancer

Spontaneous Tumor Lysis Syndrome in Recently Diagnosed Small Cell Lung Cancer

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This case demonstrates that, although rare, spontaneous TLS can occur even in the absence of chemotherapy, and a high index of suspicion for the effect should be maintained when patients with malignancies demonstrate the classic symptom of laboratory abnormalities.

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

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A double-blind study compared the effectiveness of lorazepam plus haloperidol with haloperidol alone in reducing agitation in patients with advanced cancer.

Cost of Care Significantly Increased With Carcinoid Syndrome in NETs

Cost of Care Significantly Increased With Carcinoid Syndrome in NETs

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Development of carcinoid syndrome has a profound effect on cost of care for patients with neuroendocrine tumors (NETs).

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

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Intractable hiccups can be especially problematic in the advanced cancer and palliative care settings. Dr Thompson, an oncology pharmacist, reviews options for effective medical management of this condition.

Propolis Effectively Prevents Chemotherapy-Induced Oral Mucositis

Propolis Effectively Prevents Chemotherapy-Induced Oral Mucositis

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In a randomized clinical trial, use of a mouth rinse consisting of propolis with sodium bicarbonate was well-tolerated and effectively prevented oral mucositis in patients with breast cancer undergoing adjuvant chemotherapy.

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

Frozen Gloves Reduced Chemotherapy-Induced PN, Improved Quality of Life

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Quality of life for patients with CIPN was improved by wearing frozen gloves during treatment. Researchers reported in an oral presentation at ESMO 2017 Congress that the gloves reduced symptoms even though long-term differences in neuropathy were not observed.

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

Daratumumab Infusion-Related Reactions Managed by Pre/Postinfusion Medications

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Patients with multiple myeloma treated with daratumumab who experience IRRs may easily be managed by administering pre-infusion and postinfusion medications, investigators reported in a presentation at ESMO 2017 Congress.

Adding Thalidomide to Palonosetron, Dexamethasone Reduces CINV

Adding Thalidomide to Palonosetron, Dexamethasone Reduces CINV

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Delayed CINV was improved significantly in patients receiving highly emetogenic chemotherapy for cancer when thalidomide was added to palonosetron and dexamethasone regimen.

Two FDA Approvals Propel CAR T Cell Therapy Into the Limelight

Two FDA Approvals Propel CAR T Cell Therapy Into the Limelight

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The first FDA approval of a CAR T cell therapy is granted for the treatment of B-cell precursor ALL. FDA also approves rheumatoid arthritis medication for the management of cytokine release syndrome, a common and serious adverse effect of CAR T cell therapy

Androgen Deprivation Therapy for Prostate Cancer Increases Risk of CVD

Androgen Deprivation Therapy for Prostate Cancer Increases Risk of CVD

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The risk of cardiovascular disease such as heart failure, arrhythmias, and conduction disorders are greater in men with localized prostate cancer who were treated with androgen deprivation therapy.

Hyponatremia May Lead to Worse Symptom Severity, Frequency in Cancer

Hyponatremia May Lead to Worse Symptom Severity, Frequency in Cancer

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Patients with cancer who develop hyponatremia suffer from more symptoms with greater severity than normonatremic patients; however, no significant association was found between in-hospital mortality or length of hospital stay and hyponatremia.

Early Recognition of Checkpoint Inhibitor-Related Pneumonitis Improves Outcomes

Early Recognition of Checkpoint Inhibitor-Related Pneumonitis Improves Outcomes

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As the use of checkpoint inhibitors increases in many types of cancer, oncology nurses need to learn to recognize the signs and symptoms of pneumonitis, a rare but life-threatening adverse effect of these agents.

Most Skull Radiation Patients Show No Cognitive Impairment

Most Skull Radiation Patients Show No Cognitive Impairment

The researchers found that the majority of patients had no frank detectable cognitive impairment after undergoing skull base irradiation.

Physical Activity Improves Cognitive Function for Breast Cancer Survivors

Physical Activity Improves Cognitive Function for Breast Cancer Survivors

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Moderate-to-vigorous physical activity was found to improve working memory and executive function in survivors of breast cancer.

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

Chemotherapy-associated Paronychia Treated With 2% Povidone-iodine: A Series of Cases

[Cancer Management and Research] This research examines cases of chemotherapy-induced nail changes in individuals treated with taxanes and EGFR inhibitors.

Neuropathic Cancer Pain Linked to Reduced Quality of Life

Neuropathic Cancer Pain Linked to Reduced Quality of Life

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Results of a recent study showed that neuropathic cancer pain (NCP) in patients with cancer was not only associated with a worsened quality of life but is also not adequately managed.

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

Dexamethasone-Induced Hiccups in Chemotherapy May be Prevented by Rotating to Methylprednisolone

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Rotating dexamethasone and methylprednisolone can help to alleviate dexamethasone-induced hiccups (DIH) without the loss of antiemetic effects in patients undergoing chemotherapy.

Rates of Pregnancy Significantly Lower in Cancer Survivors Compared With General Population

Rates of Pregnancy Significantly Lower in Cancer Survivors Compared With General Population

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Girls and women aged 39 years and younger may be up to 38% less likely to achieve pregnancy after surviving cancer vs patients who have never had cancer.

PHQ-9 and HADS-D May be Limited in Assessment of MDD in Patients With Cancer

PHQ-9 and HADS-D May be Limited in Assessment of MDD in Patients With Cancer

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Results of a recent study found that the effectiveness of the 9-item Patient Health Questionnaire (PHQ-9) and the Hospital Anxiety and Depression Scale (HADS-D) in screening for major depressive disorder (MDD) in patients with cancer was limited compared to the standardized diagnostic interview.

Long-Term Use of TPO Receptor Agonist Safe in CLL-Associated Immune Thrombocytopenia

Long-Term Use of TPO Receptor Agonist Safe in CLL-Associated Immune Thrombocytopenia

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Case study demonstrates the effectiveness of long-term treatment with an oral nonpeptide receptor agonist in a 69-year-old male patient with CLL-associated ITP.

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

Taxane-based Chemotherapy May Diminish Balance, Gait in Breast Cancer Survivors

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Breast cancer survivors who received taxane-based chemotherapy for their disease are at increased risk for falls due to CIPN and treatment-associated effects on balance and gait.

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

Ovarian Function Recovery May Increase Risk of Breast Cancer Recurrence

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Ovarian function recovery (OFR) in women with chemotherapy-induced ovarian function failure decreases residual 5-year disease-free and overall survival.

Neurocognitive Function Impacts Health-Related QOL in Advanced Lung Cancer

Neurocognitive Function Impacts Health-Related QOL in Advanced Lung Cancer

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Study finds a correlation between various measures of neurocognitive function and health utility scores.

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