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Salsalate
Arthritis/rheumatic disorders
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Drug Name:

Salsalate Rx

Generic Name and Formulations:
Salsalate 500mg, 750mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Salsalate:

Rheumatoid arthritis. Osteoarthritis.

Adult:

3g daily in divided doses.

Children:

Not recommended.

Contraindications:

Varicella or influenza in teenagers. 3rd trimester pregnancy. Aspirin allergy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Advanced renal disease: not recommended. Impaired renal or hepatic function. Hypertension. Heart failure. Edema. Bleeding disorders. Monitor blood, liver, renal function with chronic use. Peptic ulcer. Gastritis. Diabetes. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

PABA may increase serum levels. May potentiate anticoagulants, hypoglycemics, methotrexate. Urinary alkalinizers, antacids, corticosteroids may increase excretion. May antagonize uricosurics and spironolactone.

See Also:

Salsalate capsules

Pharmacological Class:

Salicylate.

Adverse Reactions:

Salicylism, tinnitus, nausea, dyspepsia, GI bleed, hearing loss, rash (discontinue if occurs). See literature re: risk of cardiovascular events.

Note:

Formerly known under the brand names Disalcid, Salflex.

How Supplied:

Contact supplier.

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