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SALAGEN
Dry mouth
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Drug Name:

SALAGEN Rx

Generic Name and Formulations:
Pilocarpine (as HCl) 5mg, 7.5mg; tabs.

Company:
Eisai Pharmaceuticals

Therapeutic Use:

Indications for SALAGEN:

Dry mouth (xerostomia) due to radiotherapy for head and neck cancer or Sjogren's syndrome.

Adult:

Cancer: Initially 5mg three times daily; range 15–30mg daily; max 10mg/dose. Sjogren's syndrome: 5mg four times daily. Moderate hepatic impairment for both: 5mg twice daily.

Children:

Not recommended.

Contraindications:

Uncontrolled asthma. When miosis is undesirable (iritis, narrow-angle glaucoma).

Warnings/Precautions:

Severe hepatic impairment: not recommended. Cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. Cholethiasis. Biliary tract disease. Nephrolithiasis. Cognitive or psychiatric disorders. Activities requiring visual acuity. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Cardiac conduction disturbances with β-blockers. Potentiates parasympathomimetics. Antagonizes anticholinergics (eg, atropine, ipratropium).

Pharmacological Class:

Cholinergic.

Adverse Reactions:

Sweating, nausea, rhinitis, chills, flushing, urinary frequency, dizziness, asthenia, headache, abnormal vision.

How Supplied:

Tabs—100

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