ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

RYANODEX
Inborn errors of metabolism
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

RYANODEX Rx

Generic Name and Formulations:
Dantrolene sodium 250mg; per vial; lyophilized pwd for IV inj after reconstitution.

Company:
Eagle Pharmaceuticals

Therapeutic Use:

Indications for RYANODEX:

Treatment of malignant hyperthermia (MH) in conjunction with appropriate supportive measures. Prevention of malignant hyperthermia in high-risk patients.

Adults and Children:

Treatment: Give by IV push at a minimum of 1mg/kg; if psychologic and metabolic abnormalities continues or reappear, repeat dosing; max cumulative dose: 10mg/kg. Prevention: Start approx. 75 mins prior to surgery. 2.5mg/kg by IV over ≥1 min; may give additional doses if surgery prolonged.

Warnings/Precautions:

Institute supportive measures (eg, discontinue MH-triggering agents, manage metabolic acidosis, cooling if necessary, diuretic administration). Monitor for skeletal muscle weakness, adequate ventilation, difficulty swallowing and choking. Avoid extravasation. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid MH-triggering agents. Increased risk of somnolence or dizziness with concomitant sedative agents. Concomitant calcium channel blockers: not recommended. Concomitant other muscle relaxants may potentiate neuromuscular block. Increased CNS effects with concomitant antipsychotics, anxiolytics.

Pharmacological Class:

Muscle relaxant (skeletal).

Adverse Reactions:

Loss of grip strength, weakness in the legs, drowsiness, flushing, somnolence, dizziness, nausea, thrombophlebitis, tissue necrosis secondary to extravasation, urticaria, inj site reactions (eg, pain, erythema, swelling); dyspnea, dysphasia.

How Supplied:

Single-use vial (20mL)—1 (w. diluent)

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs